l(3)67BDp, NBS1, l(3)67BDr, Nijmegen breakage syndrome
encodes a multifunctional protein that plays critical roles in the response to DNA damage and telomere maintenance - part of a protein complex, MRN, that senses DNA strand breaks and amplifies the signal and then conveys it to downstream effectors, such as ATM and p53, that regulate cell cycle checkpoints and DNA repair
Please see the JBrowse view of Dmel\nbs for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Mutation in sequenced strain; single base change at splice site. Alternative downstream splice donor may be used.
Gene model reviewed during 6.02
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 6.04
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nbs using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\nbs in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
nbs is required to maintain chromosome integrity and to prevent telomere fusion. nbs mediates transport of the mre11/rad50 complex in the nucleus. nbs and the mre11/rad50 complex play partially independent roles in telomere protection and nbs appears to function in both mei-41- and tefu-controlled telomere protection pathways.
nbs is essential for cell cycle arrest at high doses of X-irradiation.
Identification: Defined on basis of DNA sequence similarity to NBS (Nijmegen Breakage Syndrome).
Source for merge of: nbs CG6754
Source for merge of: nbs l(3)67BDp
Source for merge of: nbs l(3)67BDr
FlyBase curator comment: the insertion in the "c06100" Exelixis line (PBac{PB}deflc06100) was originally assigned to the nbs gene in FBrf0179797, resulting in the "nbsc06100" (FBal0158901) allele. However, FBrf0184340 shows that the insertion is actually within defl.