l(2)k08015, Inr-a
RNA binding motif protein - dismantles elongation complexes by a RNA Polymerase II C-terminal domain (CTD) dependent mechanism - forms a bridge between the CTD and RNA
Please see the JBrowse view of Dmel\Pcf11 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pcf11 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Pcf11 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene.
Pcf11 inhibits transcription elongation by PolIIA under conditions that promote pausing.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Area matching Drosophila EST AA978927. This EST has sequence similarity to human PCF11p homolgue.
The Inr-a regulatory gene interacts with the white locus via regulatory sequences.
Source for merge of: l(2)k08015 CG10228
Source for merge of: l(2)k08015 anon-WO0118547.146
Source for merge of: Inr-a Pcf11
Source for merge of l(2)k08015 anon-WO0118547.146 was sequence comparison ( date:051113 ).
Source for identity of: Pcf11 l(2)k08015
Source for identity of: Pcf11 Inr-a
The gene symbol "Inr-a" has been changed to "Pcf11" to reflect the preferred usage in the literature and in order to reduce confusion with the "Inr-A" ("Inverse-regulator-Adh") gene symbol, from which it differed only by case.
Named 'Pcf11' after the yeast ortholog.