FlyBase Gene Report: Dmel\Trpm

General Information

Symbol

Dmel\Trpm

Species

D. melanogaster

Name

Transient receptor potential cation channel, subfamily M

Annotation Symbol

CG44240

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265194

Gene Model Status

Current

Stock Availability

82 publicly available

Gene Summary

Calcium channel mediating constitutive calcium ion entry. (UniProt, A8DYE2)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dTRPM

Key Links

Genomic Location

Cytogenetic map

51E11-51F4

Sequence location

2R:15,262,808..15,309,368 [-]

Recombination map

2-74

RefSeq locus

NT_033778 REGION:15262808..15309368

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables inorganic cation transmembrane transporter activity

inferred from direct assay

(Georgiev et al., 2010)

enables intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity

inferred from direct assay

(Feng et al., 2014)

enables zinc ion transmembrane transporter activity

inferred from direct assay

(Georgiev et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables monoatomic cation channel activity

inferred from biological aspect of ancestor with PANTHER:PTN001013045

(GO Reference Genome Project, 2011-)

enables monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in intracellular zinc ion homeostasis

inferred from mutant phenotype

(Georgiev et al., 2010)

involved_in magnesium ion homeostasis

inferred from mutant phenotype

(Hofmann et al., 2010)

involved_in metal ion transport

inferred from direct assay

(Georgiev et al., 2010)

involved_in monoatomic cation transmembrane transport

inferred from direct assay

(Feng et al., 2014)

NOT involved_in thermotaxis

inferred from mutant phenotype

(Rosenzweig et al., 2005)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in metal ion transport

inferred from biological aspect of ancestor with PANTHER:PTN001013045

(GO Reference Genome Project, 2011-)

involved_in monoatomic cation transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN001013045

(GO Reference Genome Project, 2011-)

involved_in monoatomic ion transport

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

involved_in protein tetramerization

inferred from electronic annotation with InterPro:IPR032415, InterPro:IPR037162

(InterPro Project Members, 2004-)

involved_in transmembrane transport

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of cation channel complex

inferred from direct assay

(Georgiev et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR005821

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001013045

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TRANSIENT RECEPTOR POTENTIAL ION CHANNELS

Protein Family (UniProt)

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. (A8DYE2)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

zinc ion transmembrane transporter activity
RHEA 29351:

Summaries

Gene Group (FlyBase)

TRANSIENT RECEPTOR POTENTIAL ION CHANNELS -: The Transient Receptor Potential (TRP) channel family are cation channels conserved from invertebrates to humans. TRP channels respond to diverse stimuli and are involved in a number of environmental sensory pathways. (Adapted from FBrf0220930 and FBrf0225477).

Protein Function (UniProtKB)

Calcium channel mediating constitutive calcium ion entry.

(UniProt, A8DYE2)

Summary (Interactive Fly)

mediates the calcium influx and initiates the calcium wave during Drosophila egg activation - senses oxidative stress to release Zn(2+) from unique intracellular vesicles - mediates aversion to cold

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Trpm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8DYE2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.49

Gene model reviewed during 6.46

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011, Stapleton et al., 2006)

nuclear_gene

(FlyBase Genome Annotators, 2012)

protein_coding_gene

(FlyBase Genome Annotators, 2012)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Trpm-RA

FBtr0339074

NM_001144200

7239

1939

Trpm-RB

FBtr0339075

NM_001043083

4880

1131

Trpm-RD

FBtr0339076

NM_001043084

7028

1921

Trpm-RE

FBtr0339077

NM_001103850

7114

2023

Trpm-RF

FBtr0339078

NM_001043085

7253

1996

Trpm-RG

FBtr0339079

NM_001144201

7419

1928

Trpm-RH

FBtr0339080

NM_001299517

7700

1968

Trpm-RI

FBtr0339081

NM_001299518

7638

1953

Trpm-RJ

FBtr0339082

NM_001299519

6833

1856

Trpm-RK

FBtr0481668

NM_001414108

7607

1937

Trpm-RL

FBtr0481669

NM_001414109

7964

2056

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Trpm-PA

FBpp0308220

216.5

1939

6.59

FBpp0308221

129.3

1131

7.65

NP_001036548

AAF58153

Trpm-PD

FBpp0308222

214.6

1921

6.34

NP_001036549

ABI31097

Trpm-PE

FBpp0308223

225.5

2023

6.94

FBpp0308224

222.0

1996

6.47

NP_001036550

AAM68528

Trpm-PG

FBpp0308225

215.2

1928

6.63

FBpp0308226

219.6

1968

6.74

FBpp0308227

218.0

1953

6.86

FBpp0308228

207.5

1856

6.20

FBpp0428446

216.3

1937

6.72

UYI57900

Trpm-PL

FBpp0428447

228.7

2056

7.20

UYI57901

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Trpm using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.81

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic anal pad

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic stage 16 -- 17

embryonic/larval Malpighian tubule

(Hofmann et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval Malpighian tubule Type I cell

(Hofmann et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of cation channel complex

inferred from direct assay

(Georgiev et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Trpm in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Trpm

View exonic expression by tissue for Dmel\Trpm

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265194

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36694/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265194

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0083959

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265194

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Trpm

Transgenic constructs containing regulatory region of Trpm

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)XTE-11

(Georgiev et al., 2010)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Trpm^{MI05302-GFSTF.1}

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Trpm^GD4541

lethal (with Df(2R)BSC346)

Trpm^{MI09739-TG4.0}

lethal (with Df(2R)XTE-18)

lethal (with Trpm¹)

lethal (with Trpm²)

Trpm¹

lethal (with Trpm^EY01618)

Trpm¹

lethal | larval stage | maternal effect

Trpm²⁸

lethal | prepupal stage

Trpm²⁸

lethal - all die before end of prepupal stage | recessive

lethal - all die before end of pupal stage | recessive

partially lethal | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Trpm^U6:3.gRNA1

partially lethal | maternal effect, with Spyo\Cas9^nanos.PU

Trpm^U6:3.gRNA1

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Trpm^GD9986

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Trpm^GD4541

Other Phenotypes

Allele

abnormal developmental rate | larval stage

Trpm²⁸

abnormal size | female, with Spyo\Cas9^nanos.PU

decreased cell size

Trpm²⁸

decreased cell size, with Scer\GAL4^AB1

Trpm^GD4541

majority die during embryonic stage | maternal effect, with Spyo\Cas9^nanos.PU

Trpm^U6:3.gRNA1

some die during embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Trpm^U6:3.gRNA1

some die during prepupal stage | recessive

some die during pupal stage | recessive

Phenotype manifest in

Allele

egg, with Scer\GAL4^{VP16.mat.αTub67C}

Trpm^HMC04852

egg, with Scer\GAL4^{VP16.mat.αTub67C}, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Trpm^U6:3.gRNA1

egg, with Spyo\Cas9^nanos.PU

Trpm^U6:3.gRNA1

embryonic/larval anterior Malpighian tubule

Trpm¹

embryonic/larval fat body

Trpm²

mitochondrion

Trpm²⁸

mitochondrion, with Scer\GAL4^34B

Trpm^GD4541

ovary, with Spyo\Cas9^nanos.PU

salivary gland, with Scer\GAL4^AB1

Trpm^GD4541

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\TRPM3

12 of 14

Yes

Hsap\TRPM6

11 of 14

Yes

Hsap\TRPM1

10 of 14

Yes

Hsap\TRPM7

10 of 14

Yes

Hsap\TRPM8

4 of 14

Yes

Hsap\TRPM2

3 of 14

Yes

Hsap\TRPM4

3 of 14

Yes

Hsap\TRPM5

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (16)

Rnor\Trpm3

12 of 14

Yes

Rnor\Trpm1

10 of 14

Yes

Rnor\Trpm7

10 of 14

Yes

Rnor\Trpm6

9 of 14

Yes

Rnor\Trpm8

4 of 14

Yes

Rnor\Trpm2

3 of 14

Yes

Rnor\Trpm4

3 of 14

Yes

Rnor\Trpm5

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (16)

Mmus\Trpm3

12 of 14

Yes

Mmus\Trpm6

11 of 14

Yes

Mmus\Trpm1

10 of 14

Yes

Mmus\Trpm7

10 of 14

Yes

Mmus\Trpm4

3 of 14

Yes

Mmus\Trpm5

3 of 14

Yes

Mmus\Trpm2

2 of 14

Yes

Mmus\Trpm8

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\trpm3

10 of 13

Yes

Xtro\trpm6

8 of 13

Yes

Xtro\trpm1

6 of 13

Yes

Xtro\XB5892783

6 of 13

Yes

Xtro\trpm7

5 of 13

Xtro\trpm8b

2 of 13

Yes

Xtro\trpm8

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\trim26

1 of 13

Yes

Xtro\trpc1

1 of 13

Xtro\trpc4

1 of 13

Xtro\trpm2

1 of 13

Yes

Xtro\trpm4

1 of 13

Yes

Xtro\trpm5

1 of 13

Yes

Xtro\trpv4

1 of 13

Xtro\vta1

1 of 13

Danio rerio (Zebrafish) (23)

Drer\trpm3

12 of 14

Yes

Drer\trpm1a

11 of 14

Yes

Drer\trpm1b

9 of 14

Yes

Drer\trpm7

8 of 14

Yes

Drer\trpm6

7 of 14

Yes

Drer\trpm4a

3 of 14

Yes

Drer\trpm4b3

3 of 14

Yes

Drer\trpm4b.2

3 of 14

Yes

Drer\trpm5

3 of 14

Yes

Drer\trpm2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\trpn1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\gon-2

9 of 14

Yes

Cele\gtl-1

5 of 14

Yes

Cele\gtl-2

5 of 14

Yes

Cele\ced-11

2 of 14

Yes

Cele\F13B12.3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP006825

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Trpm. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (4)

nompC

1 of 13

Trpγ

1 of 13

trpl

1 of 13

trp

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Trpm^GD4541

model of chromosome 15q13.3 microdeletion syndrome

CEA

(Yusuff et al., 2020)

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

TRPM6; transient receptor potential cation channel subfamily M member 6

model of intestinal hypomagnesemia 1

IEA

(FlyBase, 2019-)

TRPM7; transient receptor potential cation channel subfamily M member 7

model of amyotrophic lateral sclerosis-parkinsonism/dementia complex 1

IEA

(FlyBase, 2019-)

TRPM1; transient receptor potential cation channel subfamily M member 1

model of congenital stationary night blindness 1C

IEA

(FlyBase, 2019-)

TRPM4; transient receptor potential cation channel subfamily M member 4

model of progressive familial heart block type IB

IEA

(FlyBase, 2019-)

model of erythrokeratodermia variabilis et progressiva 6

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Trpm^KO

ameliorates tauopathy

modeled by Hsap\MAPT^{P301L.QUAS.0N4R}

(Praschberger et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TRPM3; transient receptor potential cation channel subfamily M member 3

12 of 14

608961

TRPM6; transient receptor potential cation channel subfamily M member 6

11 of 14

607009

HYPOMAGNESEMIA 1, INTESTINAL; HOMG1

intestinal hypomagnesemia 1

TRPM1; transient receptor potential cation channel subfamily M member 1

10 of 14

603576

NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1C; CSNB1C

congenital stationary night blindness 1C

TRPM7; transient receptor potential cation channel subfamily M member 7

10 of 14

605692

AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM/DEMENTIA COMPLEX 1

amyotrophic lateral sclerosis-parkinsonism/dementia complex 1

TRPM8; transient receptor potential cation channel subfamily M member 8

4 of 14

606678

TRPM2; transient receptor potential cation channel subfamily M member 2

3 of 14

603749

TRPM4; transient receptor potential cation channel subfamily M member 4

3 of 14

606936

TRPM5; transient receptor potential cation channel subfamily M member 5

3 of 14

604600

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Pi3K92E

suppressible

Trpm

(Georgiev et al., 2010)

S6k

suppressible

Trpm

(Georgiev et al., 2010)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265194

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

TRP channels

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-74

Cytogenetic map

51E11-51F4

Sequence location

2R:15,262,808..15,309,368 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

51E11-51F4

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-74

(FlyBase, 2016)

2-77.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (82)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

93763

w^*; Trpm^KO/CyO

35527

w^*; TI{TI}Trpm²/CyO

47892

w¹¹¹⁸; P{GMR20F06-GAL4}attP2

48613

w¹¹¹⁸; P{GMR20G07-GAL4}attP2

Korea

15571

P{GMR19F01-GAL4}JK22C

15951

P{GMR20A08-lexA}JK22C

16310

P{GMR19F01-lexA}su(Hw)attP5

VDRC

v107537

P{KK112299}VIE-260B

v110226

P{KK102870}VIE-260B

v33670

w¹¹¹⁸ P{GD9986}v33670

v30609

w¹¹¹⁸; P{GD4541}v30609

v30610

w¹¹¹⁸; P{GD4541}v30610

More stocks available...

Genomic Clones (47)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0265194

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Hofmann et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG34187) in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG30079 BcDNA:GH04950

(FlyBase, 1996-)

Source for merge of: CG30079 CG30078

(FlyBase Genome Annotators, 2006)

Additional comments

Annotation CG34123 and the coding portion of CG34187 merged as CG44240 in release 5.49 of the genome annotation. The 5' portion of CG34187 was split out as CR44241. Split/merge based on RNA-seq junction and RNA-seq expression data.

(FlyBase Genome Annotators, 2012)

Annotations CG34123 and CG34187 underwent a split/merge in release 5.49 of the genome annotation, resulting in annotations CG44240 and CR44241.

(FlyBase Genome Annotators, 2012)

Annotations CG30079 and CG30078 merged as CG34123 in release 5.1 of the genome annotation.

(FlyBase Genome Annotators, 2006)

Annotation CG16805 split into CG30078 and CG30079 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG30079 BcDNA:GH04950 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: trpm CG34123

(Hofmann et al., 2010)

Source for identity of: Trpm trpm

(FlyBase, 2009-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (17)

Reported As

Symbol Synonym

BcDNA:GH04950

CG16805

(Manning et al., 2012, Roos et al., 2005)

CG30078

(Montell, 2005, Giot et al., 2003, Manning, 2002.11.16)

CG30079

(Stapleton et al., 2006, Montell, 2005, Foley and O'Farrell, 2004)

CG34123

(Ashwal-Fluss et al., 2014, Kanamori et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Tsubouchi et al., 2012, Adamson et al., 2011, Ni et al., 2011.7.19, Shieh and Bonini, 2011, Georgiev et al., 2010, Hofmann et al., 2010, Ni et al., 2010.12.1, Wasbrough et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2008, Muse et al., 2007)

CG34187

(FlyBase Genome Annotators, 2007)

CG44240

(National Institute of Genetics Fly Stocks, 2022-, Trivedi et al., 2020, Balakrishnan et al., 2015, FlyBase Genome Annotators, 2012, Ni et al., 2010.12.1)

DmTRPM

(Matsuura et al., 2009)

TRPM

(Liu et al., 2022, Montell, 2021, Guo et al., 2020, Su et al., 2018, Transgenic RNAi Project members, 2017-, Venkatachalam et al., 2014, Antunes et al., 2013, Fowler and Montell, 2013, Caterina and Montell, 2005)

TrpM

(Tsubouchi et al., 2012, Rosenzweig et al., 2005)

Trpm

(Corthals et al., 2023, Praschberger et al., 2023, Liu and Zhang, 2022, Marcogliese et al., 2022, Sebastian et al., 2022, O'Connor et al., 2021, Pang et al., 2021, Xie et al., 2021, Fujisawa et al., 2020, Himmel and Cox, 2020, Yusuff et al., 2020, He et al., 2019, Lee et al., 2018, Gene Disruption Project members, 2016-, Gene Disruption Project members, 2015-, Menuz et al., 2014)

dTRPM

(Georgiev et al., 2010, Georgiev et al., 2010)

mdcds_11815

(Chen and Oliver, 2014.8.15)

trpm

(Tian et al., 2022, York-Andersen et al., 2021, Jacobs and Sehgal, 2020, Ma and Freeman, 2020, Hu and Wolfner, 2019, Rimal and Lee, 2019, Weavers et al., 2019, Xu et al., 2019, Kanamori et al., 2013, Kwon et al., 2013, Sartain and Wolfner, 2013, FlyBase Genome Annotators, 2012, Rodriguez et al., 2012, Hofmann et al., 2010, Kwon et al., 2010, Montell, 2005)

Name Synonyms

Transient receptor potential cation channel, subfamily M

Transient receptor potential cation channel, subfamily M ortholog

transient receptor potential channel M

(Antunes et al., 2013)

Secondary FlyBase IDs

FBgn0083959
FBan0030079
FBgn0034006
FBgn0050078
FBgn0050079
FBgn0064975
FBgn0265175
FBgn0085216

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 80 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36694

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8DYE2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

A8DYE2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8DYE2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265194

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36694/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265194

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265194

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG44240

MARRVEL_MODEL - MARRVEL (model organism gene)

36694

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0265194

DroID - A comprehensive database of gene and protein interactions.

FBgn0265194

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0083959

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0265194

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0265194

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC009943

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

TRP channels

References (116)

The following external sites may use different assemblies or annotations than FlyBase.

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