PNS, maintains microtubule stability/dynamics with the microtubule-associated protein Futsch - splice factor Rtca suppresses Xbp1 via nonconventional mRNA splicing, which in turn reduces ringer expression to inhibit axon regeneration - lies downstream from and is negatively regulated by the microtubule-associated deacetylase HDAC6
Please see the JBrowse view of Dmel\ringer for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
Gene model reviewed during 5.45
Gene model reviewed during 5.53
Gene model reviewed during 6.02
Found in a complex with tubulin and Futsch.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ringer using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
ringer protein is prominantly expressed in the embryonic ventral midline with some expression in the surrounding CNS and PNS. It is expressed in both neurons and glial cells in the midline. The neurons have been identified as the MP1 neuron starting at embryonic stage 13 and aCC, pCC, and RP2 neurons starting at stage 14.
JBrowse - Visual display of RNA-Seq signals
View Dmel\ringer in JBrowse3-44
3-38.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
New annotation (CG34249) in release 5.2 of the genome annotation.
Source for merge of: CG34249 CG4893
Source for merge of: CG45057 CG45027
Annotations CG34249 and CG4893 merged as CG45057 in release 5.53 of the genome annotation. Merge based on RNA-Seq junction and expression data.
Annotations CG45057 and CG45027 merged as CG45057 in release 5.54 of the genome annotation. They were duplicated annotations.
Source for identity of: ringer CG45057
