FlyBase Gene Report: Dmel\Snap24

General Information

Symbol

Dmel\Snap24

Species

D. melanogaster

Name

Synaptosomal-associated protein 24kDa

Annotation Symbol

CG9474

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266720

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

SNAP-24, Synapse protein 24, Snap25b

Key Links

Genomic Location

Cytogenetic map

85E6-85E7

Sequence location

3R:9,761,305..9,763,150 [-]

Recombination map

3-49

RefSeq locus

NT_033777 REGION:9761305..9763150

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables SNAP receptor activity

inferred from sequence or structural similarity

(Littleton, 2000)

inferred from sequence or structural similarity with RGD:620221

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000447753

(GO Reference Genome Project, 2011-)

enables syntaxin binding

inferred from sequence or structural similarity with RGD:620221

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000447753

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

involved_in exocytosis

inferred from biological aspect of ancestor with PANTHER:PTN000447753

(GO Reference Genome Project, 2011-)

involved_in Golgi to plasma membrane transport

inferred from sequence or structural similarity

(Littleton, 2000)

involved_in membrane fusion

inferred from sequence or structural similarity with RGD:620221

(Gene Ontology Curators, 2002-)

involved_in neurotransmitter secretion

non-traceable author statement

(Lloyd et al., 2000)

involved_in synaptic vesicle fusion to presynaptic active zone membrane

inferred from biological aspect of ancestor with PANTHER:PTN000447754

(GO Reference Genome Project, 2011-)

involved_in synaptic vesicle priming

inferred from biological aspect of ancestor with PANTHER:PTN000447754

(GO Reference Genome Project, 2011-)

involved_in vesicle-mediated transport

inferred from sequence or structural similarity with RGD:620221

(Gene Ontology Curators, 2002-)

non-traceable author statement

(Lloyd et al., 2000)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

located_in secretory granule membrane

inferred from direct assay

(Burgess et al., 2012)

colocalizes_with secretory granule

inferred from direct assay

(Niemeyer and Schwarz, 2000)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000447752

(GO Reference Genome Project, 2011-)

part_of SNARE complex

inferred from biological aspect of ancestor with PANTHER:PTN000447753

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with RGD:620221

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

Qbc-SNAREs

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

Qbc-SNAREs -: Q-SNAREs are members of the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor) family that mediate vesicle-fusion. SNAREs are cytoplasmic, membrane-anchored proteins that contain a 60 amino acid SNARE domain. Three Q-SNAREs domains from the target membrane and one R-SNARE domain from the vesicle interact to form a four four-helix bundle that pulls the two membranes in close proximity and promotes fusion. After fusion, the complexes are dissembled by NSF (N-ethylmaleimide-sensitive factor) and SNAPs (Soluble NSF Attachment Proteins). Q-SNAREs are named from their contribution of a conserved glutamine (Q) residue to the helix bundle. Q-SNARE domains are designated a, b or c, depending on their position within the helix bundle. Qbc-SNAREs (or SNAPs (synaptosomal-associated proteins) possess a Qb and Qc domain, thus contribute two helices to the bundle. (Adapted from PMID:15893389 and FBrf0216182).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Snap24 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VH76)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Gene model reviewed during 5.43

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Snap24-RA

FBtr0082163

NM_079574

1846

212

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Snap24-PA

FBpp0081641

23.6

212

4.40

Q9VH76

NP_524298

AAF54443

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VH76

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Snap24 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Snap24_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.23

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

located_in secretory granule membrane

inferred from direct assay

(Burgess et al., 2012)

colocalizes_with secretory granule

inferred from direct assay

(Niemeyer and Schwarz, 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Snap24 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Snap24

View exonic expression by tissue for Dmel\Snap24

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41193/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266720

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028401

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266720

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Snap24

Transgenic constructs containing regulatory region of Snap24

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Snap24^GD4050

viable, with Scer\GAL4^Mef2.PR

Snap24^GD4050

viable, with Scer\GAL4^pnr-MD237

Snap24^GD4050

viable, with Scer\GAL4^tin.CΔ4

Snap24^GD4050

Other Phenotypes

Allele

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^ppk.PG

Snap24^JF03146

abnormal size | adult stage, with Scer\GAL4^esg.PU

Phenotype manifest in

Allele

dense core granule | adult stage, with Scer\GAL4^NP0261

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^ppk.PG

Snap24^JF03146

male accessory gland secondary cell, with Scer\GAL4^esg.PU

male accessory gland secondary cell, with Scer\GAL4^NP0261

nucleus | adult stage, with Scer\GAL4^esg.PU

nurse cell | oogenesis stage S13, with Scer\GAL4^GR1

Snap24^JF03146

nurse cell | oogenesis stage S14 | increased number, with Scer\GAL4^GR1

Snap24^JF03146

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (4)

Hsap\SNAP25

14 of 14

Yes

Hsap\SNAP23

11 of 14

Yes

Hsap\SNAP29

2 of 14

Hsap\SNAP47

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Snap25

12 of 14

Yes

Rnor\Snap23

10 of 14

Yes

Rnor\Snap29

2 of 14

Rnor\Snap47

1 of 14

Yes

Mus musculus (laboratory mouse) (4)

Mmus\Snap25

14 of 14

Yes

Mmus\Snap23

11 of 14

Yes

Mmus\Snap29

2 of 14

Mmus\Snap47

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (9)

Xtro\snap25

7 of 13

Yes

Xtro\LOC100491227

6 of 13

Xtro\snap23

5 of 13

Yes

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (6)

Drer\snap25a

14 of 14

Yes

Drer\snap25b

13 of 14

Yes

Drer\zgc:101731

13 of 14

Drer\snap23.1

12 of 14

Yes

Drer\snap23.2

6 of 14

Yes

Drer\snap29

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\ric-4

12 of 14

Yes

Cele\aex-4

4 of 14

Yes

Cele\snap-29

2 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP001394

6 of 12

Yes

Agam\AgaP_AGAP011135

2 of 12

Arabidopsis thaliana (thale-cress) (3)

Atha\SNAP29

10 of 13

Yes

Atha\SNAP30

10 of 13

Yes

Atha\SNAP33

10 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\SEC9

6 of 13

Yes

Scer\SPO20

5 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\sec9

6 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Snap24. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

Snap25

12 of 13

Snap29

4 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SNAP25; synaptosome associated protein 25

model of congenital myasthenic syndrome 18

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SNAP25; synaptosome associated protein 25

14 of 14

600322

MYASTHENIC SYNDROME, CONGENITAL, 18; CMS18

congenital myasthenic syndrome 18

SNAP23; synaptosome associated protein 23

11 of 14

602534

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Snap24 - AttD

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Bet1

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Gos28

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Membrin

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Rme-8

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Sec20

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Sec22

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Slh

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Snap25

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Snap29

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Syb

comigration in sds page, western blot, experimental knowledge based

(Guruharsha et al., 2011, Niemeyer and Schwarz, 2000)

Snap24 - Syx13

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Syx16

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Syx18

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Syx1A

experimental knowledge based, comigration in sds page, western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry

(Gordon et al., 2017, Guruharsha et al., 2011, Niemeyer and Schwarz, 2000)

Snap24 - Syx4

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Syx5

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Syx6

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Syx7

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Syx8

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Use1

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Vamp7

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Vti1a

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - Ykt6

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - koko

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - nSyb

comigration in sds page, western blot, experimental knowledge based

(Guruharsha et al., 2011, Niemeyer and Schwarz, 2000)

Snap24 - αSnap

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - γSnap1

experimental knowledge based

(Guruharsha et al., 2011)

Snap24 - γSnap2

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Snap25

suppressible

Snap24

(Vilinsky et al., 2002)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266720

MIST (protein-protein) - An integrated Molecular Interaction Database

41193

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-49

Cytogenetic map

85E6-85E7

Sequence location

3R:9,761,305..9,763,150 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

85E6-85E7

Limits computationally determined from genome sequence between P{EP}Crc^EP3006 and P{lacW}s2681

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

85E10-85E13

(determined by in situ hybridisation)

(Niemeyer and Schwarz, 2000)

85E10-85E13

(Niemeyer, 1999.9.16)

85F-85F

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

3-49

(FlyBase, 2016)

3-46.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

81902

w^*; PBac{U6:3-Snap24.gRNA}VK00027

28719

y¹ v¹; P{TRiP.JF03146}attP2

81908

w^*; PBac{U6:3-Snap24-Snap25.gRNA}VK00027

81907

w^*; PBac{U6:3-Snap24-Snap25-Snap29.gRNA}VK00027

84035

y¹ sc^* v¹ sev²¹; P{TKO.GS04409}attP40

FlyORF

F002728

M{UAS-Snap24.ORF.3xHA.GW}ZH-86Fb

VDRC

v108209

P{KK101630}VIE-260B

v48033

w¹¹¹⁸; P{GD4050}v48033

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (7)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP08944

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266720

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Source for merge of: Snap24 CG9474

(FlyBase, 1996-)

Source for merge of: Snap24 Snap25b

(FlyBase, 1992-)

Additional comments

Source for merge of Snap24 CG9474 was sequence comparison ( date:000605 ).

(FlyBase, 1996-)

BLAST analysis using human SNAP25 confirms that 'SNAP-25b' mentioned solely in FBrf0129948 is identical to 'Snap24'.

(FlyBase, 1992-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG9474

(Hosono et al., 2015, Cammarato et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Dorer et al., 2006, Verstreken and Bellen, 2000.9.4)

SNAP-24

(Kloepper et al., 2008, Lagow et al., 2007, Vilinsky et al., 2002, Vilinsky et al., 2002, Lloyd et al., 2000, Niemeyer and Schwarz, 2000, Niemeyer, 1999.9.16, Niemeyer and Schwarz, 1999)

SNAP-25b

(Littleton, 2000)

SNAP24

(Gordon et al., 2017, Drummond et al., 2001)

Snap24

(Uçkun et al., 2021, González-Méndez et al., 2020, Warecki et al., 2020, Mondragon et al., 2019, Poe et al., 2019, Gerards et al., 2018, Transgenic RNAi Project members, 2017-, Van Bortle et al., 2015, Burgess et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Tan et al., 2009, Stuart et al., 2007)

Snap25b

dSnap24

(Porcellato et al., 2022)

snap24

(González-Méndez et al., 2020)

Name Synonyms

Snap25b

Synapse protein 24

(Cammarato et al., 2011, Niemeyer and Schwarz, 1999)

Synaptosomal-associated protein 24kDa

Secondary FlyBase IDs

FBgn0028401
FBgn0037745
FBgn0044818

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41193

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF187106

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VH76

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VH76

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VH76

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41193/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266720

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266720

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9474

MARRVEL_MODEL - MARRVEL (model organism gene)

41193

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266720

DroID - A comprehensive database of gene and protein interactions.

FBgn0266720

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Snap24_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028401

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0266720

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0266720

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010177

MIST (protein-protein) - An integrated Molecular Interaction Database

41193

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (59)

The following external sites may use different assemblies or annotations than FlyBase.

-1.23

Report Sections