Xmas-2, xmas-1, X-linked male sterile 2
Please see the JBrowse view of Dmel\xmas for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Gene model reviewed during 6.26
Merge of xmas-1 and xmas-2 based on data in FBrf0238924 and RNASeq junction data.
None of the polypeptides share 100% sequence identity.
Component of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex (anchoring and mRNA export complex), composed of e(y)2, xmas and PCID2 (PubMed:18034162, PubMed:27016737). Within the TREX-2/ AMEX complex, interactions with e(y)2 is required for localization of e(y)2 to the nuclear periphery (PubMed:18034162, Ref.7). Interaction between the TREX-2/AMEX complex and the ORC complex is required for ORC localization to mRNPs, and consequently mRNA export (PubMed:27016737, PubMed:33689068). Within the TREX-2/AMEX-ORC complex, interacts with Orc6, (via C-terminus) with Orc3, and weakly interacts with Orc4 (PubMed:27016737, PubMed:33689068). However, another report found that the interaction with Orc3 is not direct, instead it is mediated via e(y)2 (Ref.7). Interacts with piwi (PubMed:28472469).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\xmas using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\xmas in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: xmas-1 xmas-2
Annotations CG32561 and CG32562 merged as CG46386 in release 6.26 of the genome annotation. Transcripts corresponding to xmas-1-RA and xmas-2-RA are now xmas-RB and xmas-RA, respectively; a third transcript encompassing both ORFs is supported.
Annotation CG8919 split into CG32562 (xmas-2) and CG32561 (xmas-1) in release 3 of the genome annotation.