FlyBase Aberration Report: Dmel\Df(1)Bar

General Information

Symbol

Df(1)Bar

Species

D. melanogaster

Name

Deficiency (1) Bar

FlyBase ID

FBab0000327

Feature type

chromosomal_deletion

Also Known As

Df(1)B^263-20, Df(1)Bar^263-20

Computed Breakpoints include

15F1-15F2;16A7

Features within 15F1--16A7

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Dp(1;1)Bar

(Sutton, 1943)

Bar¹

Mutagen

X ray

(Sutton, 1943)

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Cook et al., 1997, McKim et al., 1996, Pauli et al., 1995, Ferrus et al., 1990, Sutton, 1943)

Breakpoints

15F1-15F2;16A7-16B1

(Ferrus et al., 1990)

15F9;16A7

(Pauli et al., 1995)

15F9-16A1;16A6-16A7

(McKim et al., 1996)

16A2;16A6

(Cook et al., 1997)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

baz << bk1 << l(1)15Fa << B << bk2 << ff

Genetic mapping information

Comments

210kb deletion.

(Higashijima et al., 1992)

Comments on Cytology

Ref: FBrf0056098.

(McKim et al., 1996)

Band 16A7 of the second repeat of the 16A region may not have been deleted.

(Sutton, 1943)

Limits of break 1 from polytene analysis (FBrf0051942) Left limit of break 2 from polytene analysis (FBrf0051942) Right limit of break 2 from polytene analysis (FBrf0080317)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Bar

(McKim et al., 1996, Higashijima et al., 1992, Higashijima et al., 1992, Sutton, 1943)

B-H1

(Kojima et al., 2000)

B-H2

(Kojima et al., 2000, Higashijima et al., 1992, Higashijima et al., 1992)

(Dickinson and Thatcher, 1997, McKim et al., 1996)

l(1)15Fa

(McKim et al., 1996)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

baz

(McKim et al., 1996)

l(1)15Bb

(McKim et al., 1996)

l(1)15Bc

(McKim et al., 1996)

l(1)15Da

(McKim et al., 1996)

l(1)15Db

(McKim et al., 1996)

l(1)15Dc

(McKim et al., 1996)

l(1)15Dd

(McKim et al., 1996)

l(1)15De

(McKim et al., 1996)

l(1)15Eb

(McKim et al., 1996)

mei-218

(McKim et al., 1996)

mit

(Gelbart, 1974)

(McKim et al., 1996)

RpS5a

(McKim et al., 1996)

xmas

(McKim et al., 1996)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

No defect in the gross morphology of distal legs is seen when Df(1)Bar clones are induced in flies carrying Dp(1;Y)Bar^S.

(Kojima et al., 2000)

Transmission rate of Dp(1;f)J21A through females to progeny is 28%, Df(1)Bar has no effect on transmission.

(Cook et al., 1997)

NOT in combination with other aberrations

Somatic clones homozygous for Df(1)Bar in the tarsal segments cause fusion of tarsal segments 2-5. This phenotype is not suppressed by ap^UAS.cOa; Scer\GAL4^Dll-md23.

(Pueyo and Couso, 2004)

Homozygous embryos have normal gut morphology.

(Merabet et al., 2002)

In gynandromorphs, in legs totally composed of cells hemizygous for Df(1)Bar, tarsal segments 2-5 are fused together into a small bulb-like, non-segmental structure having neither claws nor pulvilli, whereas other leg segments are normal. No central folding occurs in Df(1)Bar leg discs (in contrast to wild type), although more proximal folds are normally formed. Partial fusion of tarsal segments 2-5 is frequently seen when small Df(1)Bar clones are induced in the leg. Clones in the leg disc along the periphery of the early ring of B-H1 and B-H2 expression prevent central fold formation in the disc. Clones within tarsal segments 4 and 5 are occasionally associated with campaniform sensilla (normally found only at the dorsodistal tip of tarsal segment 3) and ectopic joint material is seen. In mosaic legs (containing Df(1)Bar clones) which have normal appearance, all mutant clones are outside tarsal segments 3-5, except for a single case in which a Df(1)Bar bristle was situated at the proximal tip of tarsal segment 3. No central fold formation is seen in the antennal disc in gynandromorphs in which the antennal disc is hemizygous for Df(1)Bar. Df(1)Bar antennae frequently lack the arista and basal cylinder.

(Kojima et al., 2000)

Few microchaetae are generated in mutant clones in the prescutum. PS macrochaetae do not develop in mutant clones

(Sato et al., 1999)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Midgut development of mutant embryos is wild type.

(Bilder and Scott, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Hemizygous embryos were examined with polarised light microscopy and antibody staining and found to have wild type muscle pattern and contraction.

(Drysdale et al., 1993)

The deleted region also contains X1 and T1/T2 units not relevant to eye morphogenesis and X2, an uncharacterized unit. Flies deficient for the Bar region have unpatterned, excess cells in the interommatidial space. The secondary effects of this is extensive distortions in rhadomere structure. The absence of Bar may result in aberrant lens formation.

(Higashijima et al., 1992)

Hemizygotes die at an early larval stage.

(Higashijima et al., 1992)

Eyes are wild type. Lethal in homozygous and hemizygous condition.

(Sutton, 1943)

Male lethal.

Stocks (2)

Bloomington

723

Df(1)Bar/In(1)sc⁷, In(1)AM, sc⁷ ptg⁴

Kyoto

106045

Df(1)Bar/In(1)sc⁷, In(1)AM, sc⁷ ptg⁴

Notes on Origin

Discoverer

Demerec, 1934.

(Sutton, 1943)

M. Demerec, Jan. 1934.

Revertant.

(Bridges and Brehme, 1944)

Revertant

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Lethal and cell-lethal.

(Bridges and Brehme, 1944)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

(Sanchez et al., 1994)

B263-20

(Sutton, 1943)

B^263-20

Df(1)^B263-20

(Li et al., 2016)

Df(1)B

(Crest et al., 2007)

Df(1)B263-20

(Higashijima et al., 1992)

Df(1)B^263-20

(Tajiri et al., 2007, Pueyo and Couso, 2004, Lim and Choi, 2003, Kojima et al., 2000, Sato et al., 1999, Dickinson and Thatcher, 1997, Ishimaru and Saigo, 1993, Higashijima et al., 1992, Ferrus et al., 1990, Gelbart, 1974)

Df(1)Bar

Df(1)Bar263

(Galindo et al., 2002)

Df(1)Bar^263-20

(Sakurai et al., 2007, Singh et al., 2005)

Name Synonyms

Deficiency (1) Bar

Secondary FlyBase IDs

FBal0000828

References (36)

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