FB2024_04 , released June 25, 2024
Human Disease Model Report: cancer, epithelial, LLGL-MYC-related
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General Information
Name
cancer, epithelial, LLGL-MYC-related
FlyBase ID
FBhh0001287
Disease Ontology Term
Parent Disease
OMIM
Overview

This model of epithelial cancer uses the Drosophila Scribble polarity complex gene l(2)gl in combination with the fly ortholog of the human MYC oncogene, Dmel\Myc. The highly conserved Scribble polarity complex plays a key role in determining cell polarity and cell proliferation in epithelial cells. MYC encodes a transcription factor that plays a role in cell cycle progression, apoptosis and cellular transformation.

Animals homozygous for loss-of-function mutations of Dmel\l(2)gl typically die during the larval stage and exhibit abnormal overproliferation of multiple tissues. Epithelial phenotypes have been assessed using mosaic clones in wing imaginal discs. Somatic clones that are homozygous for loss-of-function mutations of l(2)gl generated in wild-type imaginal discs are eliminated or reduced to very small size. When clones carrying both a loss-of-function mutation of l(2)gl and an over-expression allele of Dmel\Myc are generated, significant overgrowth is observed for clones located in the proximal part of the disc, but not for clones located in the distal part of the disc. The overproliferating clones exhibit impaired apical-basal polarity and disruptions to the basement membrane.

Transgenes of the human genes Hsap\MYC and Hsap\LLGL1 have been introduced into flies. In both cases, partial heterologous rescue (functional complementation) has been demonstrated.

See also human disease model reports 'cancer, epithelial, LLGL-related' (FBhh0000591) and 'cancer, multiple, MYC-related' (FBhh0000402).

[updated Nov. 2020 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: cancer, epithelial, LLGL-MYC-related
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information

LLGL1 and LLGL2 encode cortical cytoskeleton proteins found in a complex involved in maintaining cell polarity and epithelial integrity, the Scribble Cell Polarity Complex. This complex plays a role in the initial phase of the establishment of epithelial cell polarity; it is involved in the regulation of mitotic spindle orientation, proliferation, differentiation, and tissue organization of neuroepithelial cells. [Gene Cards, LLGL1, LLGL2; 2020.11.10]]

(FlyBase Curators, 2013-)

MYC encodes a transcription factor that plays a role in cell cycle progression, apoptosis and cellular transformation. [Gene Cards, MYC; 2020.11.10]

(FlyBase Curators, 2013-)
External links
Disease synonyms
Ortholog Information
Human gene(s) in FlyBase
Human gene (HGNC)
Symbol / Name
LLGL2; LLGL scribble cell polarity complex component 2
D. melanogaster ortholog (based on DIOPT)
Dmel\l(2)gl
(DIOPT, 2013-)
Comments on ortholog(s)

Many to one: 2 human genes to 1 Drosophila gene; the second human gene is LLGL1.

Human gene (HGNC)
Symbol / Name
LLGL1; LLGL scribble cell polarity complex component 1
D. melanogaster ortholog (based on DIOPT)
Dmel\l(2)gl
(DIOPT, 2013-)
Comments on ortholog(s)

Many to one: 2 human genes to 1 Drosophila gene; the second human gene is LLGL2.

Human gene (HGNC)
Symbol / Name
MYC; MYC proto-oncogene, bHLH transcription factor
D. melanogaster ortholog (based on DIOPT)
Dmel\Myc
(DIOPT, 2013-)
Comments on ortholog(s)

Many to one : 3 human genes to 1 Drosophila gene; additional (lower-scoring) human orthologs are MYCN and MYCL.

Other mammalian ortholog(s) used
    D. melanogaster Gene Information (2)
    Dmel\l(2)gl
    Gene Snapshot
    lethal (2) giant larvae (l(2)gl) encodes a tumor suppressor protein that regulates cell polarity and asymmetric cell division. It acts on the basolateral side of epithelial cells, antagonizing the activity of apical complex proteins encoded by baz, par-6 and aPKC. [Date last reviewed: 2019-09-26]
    Molecular function (GO)
    Cellular component (GO)
    Gene Groups / Pathways
    Comments on ortholog(s)

    Moderate- to high-scoring ortholog of human LLGL1 and LLGL2 (1 Drosophila to 2 human). Dmel\l(2)gl shares 34-36% identity and 51-54% similarity with the human genes.

    Orthologs and Alignments from DRSC
    DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
    H. sapiens (Human)
    Dmel\Myc
    Gene Snapshot
    Myc (Myc) encodes a transcription factor that is homologous to vertebrate Myc proto-oncogenes. It contributes to cell growth, cell competition and regenerative proliferation. [Date last reviewed: 2019-03-14]
    Molecular function (GO)
    Cellular component (GO)
    Gene Groups / Pathways
    Comments on ortholog(s)

    Orthologous to human gene MYC (reciprocal best hit); lower scoring ortholog of human MYCN and MYCL (1 Drosophila to 3 human). Dmel\Myc shares 31% identity and 44% similarity with human MYC, within the carboxy extents of the two proteins.

    Orthologs and Alignments from DRSC
    DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
    H. sapiens (Human)
    Other Genes Used: Viral, Bacterial, Synthetic (0)
      Summary of Physical Interactions (109 groups)
      l(2)gl
      protein-protein
      Interacting group
      Assay
      References
      l(2)gl
      anti tag coimmunoprecipitation, anti tag western blot
      (Betschinger et al., 2005)
      l(2)gl - aPKC
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, experimental knowledge based, proximity ligation assay, fluorescence microscopy
      (Portela et al., 2024, Calero-Cuenca et al., 2016, Goh et al., 2013, Guruharsha et al., 2011, Tian and Deng, 2008, Wirtz-Peitz et al., 2008, Betschinger et al., 2003)
      l(2)gl - ball
      anti tag coimmunoprecipitation, western blot
      (Link et al., 2019)
      l(2)gl - ctp
      two hybrid
      (Hu et al., 2017.6.13)
      l(2)gl - dsh
      anti tag coimmunoprecipitation, western blot
      (Kaplan and Tolwinski, 2010)
      l(2)gl - Git
      proximity ligation assay, fluorescence microscopy
      (Portela et al., 2024)
      l(2)gl - mahj
      anti tag coimmunoprecipitation, anti tag western blot
      (Tamori et al., 2010)
      l(2)gl - mts
      anti tag coimmunoprecipitation, western blot
      (Ogawa et al., 2009)
      l(2)gl - Pak
      anti tag coimmunoprecipitation, western blot
      (Bahri et al., 2010)
      l(2)gl - par-1
      anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
      (Tian and Deng, 2008)
      l(2)gl - par-6
      pull down, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, experimental knowledge based, autoradiography, anti tag western blot
      (Neumüller et al., 2012, Guruharsha et al., 2011, Wirtz-Peitz et al., 2008, Hutterer et al., 2004, Betschinger et al., 2003)
      l(2)gl - Vap33
      proximity ligation assay, fluorescence microscopy, pull down, Identification by mass spectrometry, anti tag coimmunoprecipitation, anti tag western blot
      (Portela et al., 2024, Portela et al., 2018)
      l(2)gl - Vha44
      anti tag coimmunoprecipitation, anti tag western blot
      (Portela et al., 2018)
      l(2)gl - zip
      anti tag coimmunoprecipitation, anti tag western blot
      (Betschinger et al., 2005)
      Myc
      protein-protein
      Interacting group
      Assay
      References
      Myc - Act57B
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - ago
      anti tag coimmunoprecipitation, anti tag western blot, western blot, tandem affinity purification, Identification by mass spectrometry, two hybrid, anti bait coimmunoprecipitation
      (Thevenon et al., 2020, Moberg et al., 2004)
      Myc - α-Spec
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - ana2
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Arc1
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - ash2
      anti bait coimmunoprecipitation, western blot
      (Secombe et al., 2007)
      Myc - Atac3
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - atms
      anti tag coimmunoprecipitation, anti tag western blot
      (Gerlach et al., 2017)
      Myc - Atu
      anti tag coimmunoprecipitation, western blot, anti tag western blot, proximity ligation assay, fluorescence microscopy, pull down, autoradiography, anti bait coimmunoprecipitation
      (Gerlach et al., 2017)
      Myc - bif
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Brf
      anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography
      (Steiger et al., 2008)
      Myc - brm
      anti bait coimmunoprecipitation, western blot
      (Secombe et al., 2007)
      Myc - CaMKII
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Capr
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - CCT1
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - CG1620
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - CG13775
      two hybrid array
      (Shokri et al., 2019)
      Myc - CG30122
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - CG31550
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - CG34132
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - cindr
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - CkIIα
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Ctf4
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Ctr9
      anti tag coimmunoprecipitation, anti tag western blot
      (Gerlach et al., 2017)
      Myc - Ets21C
      two hybrid array
      (Shokri et al., 2019)
      Myc - fliI
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - gro
      pull down, autoradiography, anti bait coimmunoprecipitation, western blot, anti tag western blot
      (Orian et al., 2007)
      Myc - gw
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - hang
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Hcf
      anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, pull down, autoradiography
      (Furrer et al., 2010)
      Myc - Hsc70-3
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - hyd
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - hyx
      anti tag coimmunoprecipitation, western blot
      (Gerlach et al., 2017)
      Myc - iPLA2-VIA
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Kdm5
      anti bait coimmunoprecipitation, western blot, pull down, autoradiography
      (Li et al., 2010, Secombe et al., 2007)
      Myc - kst
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - l(2)09851
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - larp
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - lqfR
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - lva
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - mask
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Max
      pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry
      (Vinayagam et al., 2016, Steiger et al., 2008, Orian et al., 2007)
      Myc - Mlc-c
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - msn
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - nito
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Ns3
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Nup50
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - org-1
      two hybrid array
      (Shokri et al., 2019)
      Myc - Osbp
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - pcm
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - PIP4K
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - pont
      pull down, western blot, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
      (Bellosta et al., 2005)
      Myc - Prp19
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - puf
      anti bait coimmunoprecipitation, western blot
      (Li et al., 2013)
      Myc - rept
      anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, pull down
      (Bellosta et al., 2005)
      Myc - rin
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL4
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL6
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL7A
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL10Ab
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL13A
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL17
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL18A
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL19
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL23A
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL28
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpL30
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpLP1
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpLP2
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpS6
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpS7
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpS9
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpS16
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpS17
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - RpS23
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - rump
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Sag1
      two hybrid array
      (Shokri et al., 2019)
      Myc - Sarm
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - scny
      anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot
      (Thevenon et al., 2020)
      Myc - sip2
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - smid
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - ssx
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - sta
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - TBPH
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - toy
      two hybrid array
      (Shokri et al., 2019)
      Myc - Usp10
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - Vha26
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - wuho
      anti tag coimmunoprecipitation, western blot
      (Rastegari et al., 2020)
      Myc - yps
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Myc - zda
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      RNA-protein
      Interacting group
      Assay
      References
      Myc - AGO1
      anti bait coimmunoprecipitation, quantitative reverse transcription pcr
      (Malik, 2021)
      Myc - bam
      anti bait coimmunoprecipitation, quantitative reverse transcription pcr
      (Malik, 2021)
      Myc - BicC
      anti bait coimmunoprecipitation, quantitative reverse transcription pcr
      (Gamberi et al., 2017)
      Myc - brat
      anti bait coimmunoprecipitation, quantitative reverse transcription pcr, anti tag coimmunoprecipitation, primer specific pcr
      (Malik, 2021, Loedige et al., 2015)
      RNA-RNA
      Interacting group
      Assay
      References
      Myc - mir-308
      quantitative reverse transcription pcr, western blot
      (Daneshvar et al., 2013)
      Alleles Reported to Model Human Disease (Disease Ontology) (18 alleles)
      l(2)gl
      Models Based on Experimental Evidence ( 7 )
      Allele
      Disease
      Evidence
      References
      l(2)gl1
      model of  brain cancer
      CEA
      (Betschinger et al., 2006)
      CEA with l(2)gl4
      (Betschinger et al., 2006)
      l(2)gl4
      model of  cancer
      CEA with Ras85DV12.cUa.UAS
      (Fangninou et al., 2023, Liu et al., 2022, Yang et al., 2022)
      CEA with Ras85DV12.UAS
      (Guo et al., 2020, Grifoni et al., 2015, Pagliarini and Xu, 2003)
      CEA
      (Janic et al., 2010, Woodhouse et al., 2003)
      model of  carcinoma
      CEA
      (Singh et al., 2022, Sollazzo et al., 2022, Rusu et al., 2021, Biehler et al., 2020, Tamori et al., 2010, Bilder et al., 2000)
      CEA with ykiUAS.cOa.Tag:V5
      (Enzo et al., 2015)
      CEA with ykiUAS.cHa
      (Singh et al., 2022)
      CEA with Ras85DV12.UAS
      (Ding et al., 2022, Singh et al., 2022, Ito and Igaki, 2021, Wu et al., 2021, Mishra-Gorur et al., 2019, Zhang et al., 2019, Srivastava et al., 2007, Igaki et al., 2006)
      CEA with Ras85DV12.cUa.UAS
      (Sun et al., 2019)
      model of  brain cancer
      CEA
      (Beaucher et al., 2007, Woodhouse et al., 2003)
      CEA with l(2)gl1
      (Betschinger et al., 2006)
      model of  kidney cancer
      CEA
      (Zeng et al., 2010)
      model of  neuroblastoma
      CEA
      (Gateff and Schneiderman, 1974)
      l(2)gl4w3
      model of  carcinoma
      CEA
      (Bilder et al., 2000)
      l(2)glHMS01522
      model of  carcinoma
      CEA with MycUAS.Tag:HA
      (Sollazzo et al., 2022)
      CEA
      (Singh et al., 2022)
      l(2)glGD4047
      model of  cancer
      CEA with RpL27A1
      (Grifoni et al., 2015)
      CEA
      (Tamori et al., 2016)
      model of  adenocarcinoma
      CEA with Ras85DV12.cUa.UAS
      (Casas-Tintó et al., 2016)
      CEA with wupAf06492, Ras85DV12.cUa.UAS
      (Casas-Tintó et al., 2016)
      model of  carcinoma
      CEA
      (Chatterjee et al., 2023, Jevitt et al., 2021)
      CEA with Nint.U.UAS
      (Jevitt et al., 2021)
      l(2)glKK100777
      model of  leukemia
      CEA with Ras85DV12.UAS
      (Arefin et al., 2017)
      model of  brain cancer
      CEA with Ras85DV12.cUa.UAS
      (Manzanero-Ortiz et al., 2021)
      l(2)glHMS01905
      model of  cancer
      CEA
      (Chatterjee et al., 2022)
      Modifiers Based on Experimental Evidence ( 4 )
      Myc
      Models Based on Experimental Evidence ( 5 )
      Modifiers Based on Experimental Evidence ( 9 )
      Allele
      Disease
      Interaction
      References
      MycHMS01538
      exacerbates  carcinoma
      modeled by salrUAS.cBa
      (Sun et al., 2020)
      MycKK103869
      ameliorates  brain cancer
      modeled by bratKK113206
      (Rebelo and Homem, 2023)
      MycαTub84B.PBb
      model of  cancer
      is ameliorated by Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
      (Levayer et al., 2015)
      is ameliorated by shgUASp.cUa
      (Levayer et al., 2015)
      is ameliorated by Diap1UAS.cHa
      (Levayer et al., 2015)
      is ameliorated by diaUASp.EGFP
      (Levayer et al., 2015)
      is ameliorated by sqhRLC.N.GFP(S65T)
      (Levayer et al., 2015)
      MycUAS.Tag:HA
      exacerbates  carcinoma
      modeled by l(2)gl4
      (Sollazzo et al., 2022)
      MycUAS.cZa
      ameliorates  tuberous sclerosis
      modeled by Tsc1UAS.cTa, gigUAS.cTa
      (Tapon et al., 2001)
      ameliorates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Singh et al., 2014)
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ138.UAS.EGFP,mRFP1
      (Singh et al., 2014)
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Pragati and Sarkar, 2021)
      ameliorates  carcinoma
      modeled by salrUAS.cBa
      (Sun et al., 2020)
      modeled by Hsap\SALL4UAS.Tag:HA
      (Sun et al., 2020)
      model of  brain cancer
      is ameliorated by Spt5HMS00153
      (Hofstetter et al., 2024)
      MycGD1419
      ameliorates  cancer
      modeled by ykiUAS.cHa
      (Ziosi et al., 2010)
      ameliorates  high grade glioma
      modeled by Wdr62UAS.Tag:HA
      (Shohayeb et al., 2020)
      ameliorates  brain cancer
      modeled by bratHMS01121
      (Diaz et al., 2024)
      MycJF01762
      ameliorates  cystic kidney disease
      modeled by BicC5
      (Gamberi et al., 2017)
      exacerbates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Singh et al., 2014)
      MycJF01761
      ameliorates  cystic kidney disease
      modeled by BicC5
      (Gamberi et al., 2017)
      ameliorates  tauopathy
      modeled by Hsap\MAPTV337M.UAS
      (Pragati et al., 2020)
      ameliorates  frontotemporal dementia
      modeled by Hsap\MAPTV337M.UAS
      (Pragati et al., 2020)
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Pragati and Sarkar, 2021)
      MycRNAi.UAS.cUa
      ameliorates  high grade glioma
      modeled by aPKCUAS.Tag:CAAX(Unk)
      (Paglia et al., 2017)
      Alleles Representing Disease-Implicated Variants
      Genetic Tools, Stocks and Reagents
      Sources of Stocks
      Contact lab of origin for a reagent not available from a public stock center.
      Bloomington Stock Center Disease Page
      Related mammalian, viral, bacterial, or synthetic transgenes
      Allele
      Transgene
      Publicly Available Stocks
      Hsap\LLGL1UAS.cGa
      P{UAS-Hugl1.G}
      Hsap\MYCUAS.cUa
      P{UAS-hMYC.U}
      Hsap\MYChs.1
      P{hs-hMYC.1}
      Hsap\MYChs.2
      P{hs-hMYC.2}
      Hsap\MYCUAS.1
      P{UAS-hMYC.1}
      Hsap\MYCUAS.2
      P{UAS-hMYC.2}
      Hsap\MYCUAS.S
      P{UAS-hMYC.S}
      Selected Drosophila transgenes
      Allele
      Transgene
      Publicly Available Stocks
      MycUAS.cZa
      P{UAS-Myc.Z}
      w1118; P{UAS-Myc.Z}132
      MycαTub84B.PBb
      P{alphaTub84B(FRT.Myc)lexA::GAD.A}
      P{ey-FLP.N}2, w* P{P-Sal}MycP0 P{αTub84B(FRT.Myc)GAL4.Bb}1/FM7a; rept35/MKRS
      MycUAS.Tag:HA
      P{UAS-Myc.HA}
      MycUAS.cUa
      P{UAS-Myc.U}
      RNAi constructs available
      Allele
      Transgene
      Publicly Available Stocks
      l(2)glRNAi.UAS.cBa
      P{UAS-l(2)gl.RNAi.B}
      l(2)glRNAi.UAS.cUa
      P{UAS-l(2)gl.RNAi.U}
      l(2)glGD4047
      P{GD4047}
      w1118; P{GD4047}v51247
      l(2)glJF01073
      P{TRiP.JF01073}
      y1 v1; P{TRiP.JF01073}attP2
      l(2)glJF01553
      P{TRiP.JF01553}
      y1 v1; P{TRiP.JF01553}attP2
      l(2)glKK100777
      P{KK100777}
      P{KK100777}VIE-260B
      l(2)glHMS01522
      P{TRiP.HMS01522}
      y1 sc* v1 sev21; P{TRiP.HMS01522}attP2
      l(2)glGL00645
      P{TRiP.GL00645}
      y1 sc* v1 sev21; P{TRiP.GL00645}attP40
      l(2)glHMS01905
      P{TRiP.HMS01905}
      y1 v1; P{TRiP.HMS01905}attP40
      l(2)glVDRC.cUa
      P{VDRC.l(2)gl.U}
      MycRNAi.UAS.cUa
      P{UAS-Myc.RNAi.U}
      MycHMJ22067
      P{TRiP.HMJ22067}
      y1 v1; P{TRiP.HMJ22067}attP40/CyO
      MycRNAi.13xlexAop.cZa
      P{13xlexAop-Myc.RNAi.Z}
      MycGD1419
      P{GD1419}
      w1118; P{GD1419}v2947
      MycJF01761
      P{TRiP.JF01761}
      y1 v1; P{TRiP.JF01761}attP2
      MycJF01762
      P{TRiP.JF01762}
      y1 v1; P{TRiP.JF01762}attP2
      MycKK103869
      P{KK103869}
      P{KK103869}VIE-260B
      MycHMS01538
      P{TRiP.HMS01538}
      y1 sc* v1 sev21; P{TRiP.HMS01538}attP2
      MycGL01314
      P{TRiP.GL01314}
      y1 sc* v1 sev21; P{TRiP.GL01314}attP40
      MycHMC03189
      P{TRiP.HMC03189}
      y1 v1; P{TRiP.HMC03189}attP40/CyO
      Selected Drosophila classical alleles
      Allele
      Allele class
      Mutagen
      Publicly Available Stocks
      l(2)gl275
      loss of function allele
      spontaneous
      l(2)gl4
      amorphic allele - genetic evidence
      spontaneous
      y1 w67c23; l(2)gl4/CyO, y+
      l(2)gl4w3
      w*; l(2)gl4w3 P{neoFRT}40A P{FRT(whs)}G13/CyO
      l(2)gl1
      spontaneous
      l(2)glts3
      ethyl methanesulfonate
      y1 w*; l(2)glts3 cn1 speck1/CyO, y+
      l(2)glGX7w-
      amorphic allele - molecular evidence
      ends-out gene targeting
      MycA51
      amorphic allele - molecular evidence
      P-element activity
      References (5)