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FB2024_03
,
released June 25, 2024
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FB2024_03
,
released June 25, 2024
Reference Report
J2G
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Reference
Citation
Xie, G., Chen, H., Jia, D., Shu, Z., Palmer, W.H., Huang, Y.C., Zeng, X., Hou, S.X., Jiao, R., Deng, W.M. (2017). The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in Drosophila Imaginal Tissues.
Cancer Res.
77(4)
: 862--873.
FlyBase ID
FBrf0234812
Publication Type
Research paper
Abstract
Components of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in various human cancers, yet only SMARCB1/hSNF5, a core member of the SWI/SNF complex, is mutated in malignant rhabdoid tumors (MRT). How SMARCB1/hSNF5 functions differently from other members of the SWI/SNF complex remains unclear. Here, we use Drosophila imaginal epithelial tissues to demonstrate that Snr1, the conserved homolog of human SMARCB1/hSNF5, prevents tumorigenesis by maintaining normal endosomal trafficking-mediated signaling cascades. Removal of Snr1 resulted in neoplastic tumorigenic overgrowth in imaginal epithelial tissues, whereas depletion of any other members of the SWI/SNF complex did not induce similar phenotypes. Unlike other components of the SWI/SNF complex that were detected only in the nucleus, Snr1 was observed in both the nucleus and the cytoplasm. Aberrant regulation of multiple signaling pathways, including Notch, JNK, and JAK/STAT, was responsible for tumor progression upon snr1-depletion. Our results suggest that the cytoplasmic Snr1 may play a tumor suppressive role in Drosophila imaginal tissues, offering a foundation for understanding the pivotal role of SMARCB1/hSNF5 in suppressing MRT during early childhood. Cancer Res; 77(4); 862-73. ©2017 AACR.
PubMed ID
27923836
PubMed Central ID
PMC7885033 (
PMC
) (
EuropePMC
)
DOI
10.1158/0008-5472.CAN-16-0963
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication
English
Additional Languages of Abstract
Parent Publication
Publication Type
Journal
Abbreviation
Cancer Res.
Title
Cancer Research
Publication Year
1941-
ISBN/ISSN
0008-5472
Data From Reference
Alleles (24)
Export to HitList
BacA\p35
UAS.cHa
brm
HM04019
brm
HMS00050
bsk
DN.UAS.cUa
Ilp8
GD1670
Mmp1
JF01336
N
JF02959
osa
HMS01738
polybromo
HMS00531
puc
UAS.cMa
rpr
UAS.C
Scer\GAL4
Act.PU
Scer\GAL4
en.PU
Scer\GAL4
ptc.PU
Snr1
19-21
Snr1
ΔC.UASp.Tag:HA
Snr1
ΔNES.UASp.Tag:HA
Snr1
GD4140
Snr1
HMS00363
Snr1
KK101602
Snr1
R3
Snr1
UASp.Tag:HA
Stat92E
06346
Stat92E
RNAi.UAS
Genes (13)
Export to HitList
BacA\p35
brm
bsk
Ilp8
Mmp1
N
osa
polybromo
puc
rpr
Scer\GAL4
Snr1
Stat92E
Human Disease Models (1)
Export to HitList
rhabdoid tumor predisposition syndrome 1
Natural transposons (1)
Export to HitList
P-element
Experimental Tools (2)
Export to HitList
Tag:HA
UASp
Transgenic Constructs (21)
Export to HitList
P{Act-GAL4.U}
P{en-GAL4.U}
P{GD1670}
P{GD4140}
P{KK101602}
P{ptc-GAL4.U}
P{TRiP.HM04019}
P{TRiP.HMS00050}
P{TRiP.HMS00363}
P{TRiP.HMS00531}
P{TRiP.HMS01738}
P{TRiP.JF01336}
P{TRiP.JF02959}
P{UAS-bsk.DN.U}
P{UAS-p35.H}
P{UASp-Snr1.ΔC.HA}
P{UASp-Snr1.ΔNES.HA}
P{UASp-Snr1.HA}
P{UAS-puc.M}
P{UAS-rpr.C}
P{UAS-Stat92E.RNAi}
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