FB2024_03 , released June 25, 2024
Allele: Dmel\cv-d1
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General Information
Symbol
Dmel\cv-d1
Species
D. melanogaster
Name
FlyBase ID
FBal0002189
Feature type
allele
Associated gene
Dmel\cv-d
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Chen et al., 2012)
Mutagen
ethyl ether
Progenitor genotype
Cytology
Description

cv-d1has an in-frame deletion in exon 5 that is predicted to remove K485-N565 from the Vg domain. Sequencing of cv-d1 RT-PCR products reveal that the mutant also fails to excise the downstream intron 7, despite the lack of any mutations in the splice sites or intron; this is predicted to add 71 erroneous amino acids and a stop codon after N758 within the DUF1943 domain.

(Chen et al., 2012)

Harbors (i) a genomic deletion (deletes K485-N565) and (ii) a splice error after codon for N758 which leads to a truncation.

(Chen et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:15,850,399..15,850,641 [-]
Comment:

In frame deletion of K485-N565. There is also a failure to remove intron 7 in the mutant despite the lack of any mutations in the intron.

(Chen et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Tracheal development appears normal in mutant larvae.

      (Baer et al., 2012)

      13% of mutants have no posterior crossvein (PCV), 36% have a floating PCV, 30% have a detached PCV, 21% are normal.

      (Chen et al., 2012)

      cv-d1/Df(3R)Exel8162 wings lack the posterior crossvein.

      Homozygotes are viable and fertile, whose only visible external defects are disruption of the posterior crossvein and, occasionally, the distal tip of vein L5, and a slight variable reduction in wing size.

      Large cv-d1 clones in the wing do not disrupt posterior crossvein development.

      (Chen et al., 2012)

      Posterior crossvein absent or reduced to an oblique fragment or bar parallel to L5. Anterior crossvein sometimes detached. RK2.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      cv-d[+]/cv-d1 is a suppressor of visible | heat sensitive phenotype of HC2.hs

      (Johannes and Preiss, 2002)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      cv-d[+]/cv-d1 is a suppressor of wing vein | ectopic | heat sensitive phenotype of HC2.hs

      (Johannes and Preiss, 2002)

      cv-d[+]/cv-d1 is a suppressor of wing | heat sensitive phenotype of HC2.hs

      (Johannes and Preiss, 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      cv-d1 is rescued by cv-dUAS.Tag:V5/Scer\GAL4Tub.PU

      (Chen et al., 2012)

      cv-d1 is rescued by cv-dUAS.Tag:V5/Scer\GAL4Hml.PG

      (Chen et al., 2012)
      Comments

      Scer\GAL4tub.PU- or Scer\GAL4Hml.PG-mediated expression of cv-dScer\UAS.T:SV5\V5 rescues posterior crossvein development in cv-d1 mutants.

      (Chen et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cv-d1
      (Baer et al., 2012, Chen et al., 2012, Chen et al., 2012, Pilgram et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)