FlyBase Allele Report: Dmel\E(z)[60]

General Information

Symbol

Dmel\E(z)⁶⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0003439

Feature type

allele

Associated gene

Dmel\E(z)

Associated Insertion(s)

H{}E(z)⁶⁰

Carried in Construct

Also Known As

E(Z)^S1, Su(z)301

Key Links

Allele class

gain of function allele

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(LaJeunesse and Shearn, 1996, Gindhart and Kaufman, 1995, Cheng et al., 1994, Peterson et al., 1994, Jones and Gelbart, 1993, Jones and Gelbart, 1990)

gain of function allele

(Jones and Gelbart, 1993, Jones and Gelbart, 1990)

Mutagen

ethyl methanesulfonate

(Jones and Gelbart, 1993)

Progenitor genotype

Associated Insertion(s)

H{}E(z)⁶⁰

Cytology

Polytene chromosomes normal.

(Jones and Gelbart, 1990)

Description

hobo insertion in codon 523, encodes a C-terminally truncated protein that lacks amino acids 524 to 760.

(Carrington and Jones, 1996)

Encodes a C-terminal truncated protein, lacking the Cys-rich and trx-homology regions.

(Jones and Jones, 1995)

3kb hobo insertion at position -1.6.

(Jones and Gelbart, 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Jones and Gelbart, 1993)

lethal | recessive

(Jones and Gelbart, 1990, Phillips and Shearn, 1990, Wu et al., 1989)

viable (with E(z)^Trm)

(Bajusz et al., 2001)

visible | dominant | homeotic

(Ruhf et al., 2001)

Phenotype Manifest In

adult abdominal segment 4 | ectopic (with E(z)^Trm)

(Bajusz et al., 2001)

adult abdominal segment 5 (with E(z)^Trm)

(Bajusz et al., 2001)

adult mesothoracic segment | ectopic (with E(z)^Trm)

(Bajusz et al., 2001)

adult metathoracic segment (with E(z)^Trm)

(Bajusz et al., 2001)

adult prothoracic segment (with E(z)^Trm)

(Bajusz et al., 2001)

mesothoracic leg

(Ruhf et al., 2001)

mesothoracic leg & sex comb | ectopic

(Jones and Gelbart, 1990)

pigment cell

(Jones and Gelbart, 1993)

sex comb

(Kodjabachian et al., 1998)

sex comb | ectopic

(Jones and Gelbart, 1990)

Detailed Description

Statement

Reference

50% of E(z)⁶⁰/E(z)^Trm flies show weak transformation of T1 to T2, 75% show weak transformation of T3 to T2, 24% show strong transformation of T3 to T2 and 100% show transformation of A5 to A4.

(Bajusz et al., 2001)

Transformation of second to first leg.

(Ruhf et al., 2001)

The total level of hydrocarbons and the level of 7-monoenes is significantly reduced in heterozygous males compared to controls. The total level of hydrocarbons and the level of 7,11-dienes is significantly decreased in heterozygous females compared to controls.

(Wicker-Thomas and Jallon, 2000)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Moderately suppresses z¹ In(1)w^m4 and z¹ In(1)rst³ but has no effect on z^v77h In(1)w^m4 and z^v77h In(1)rst³. Slight effect on z¹ or z^v77h in combinations with w^zl or w^zm.

(Judd, 1995)

In z¹ w^zm strain mutation causes reduction of eye pigmentation.

(Georgiev, 1994)

Suppression of z¹ w^zm males to produce a wild type eye colour with dark flecks. The background colour of z¹ w^zl males is marginly suppressed to become slightly darker.

(Peterson et al., 1994)

Weak dominant homeotic phenotype: ectopic sex comb teeth on mesothoracic leg.

(Jones and Gelbart, 1990)

The z suppression phenotype of E(z)⁶⁰ is suppressed by Dp(3;3)S2a3.

(Phillips and Shearn, 1990)

Heterozygotes have ectopic sex comb teeth on the male posterior legs. E(z)⁶⁰/E(z)⁶¹ heterozygotes die as pharate adults.

(Wu et al., 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

E(z)⁶⁰ has visible | homeotic phenotype, enhanceable by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Enhancer of

Statement

Reference

E(z)[+]/E(z)⁶⁰ is an enhancer of visible | recessive | homeotic phenotype of mxc^M1

(Saget et al., 1998)

Suppressor of

Statement

Reference

E(z)[+]/E(z)⁶⁰ is a suppressor | partially of visible | adult stage phenotype of eya^cs/eya¹

(Tian et al., 2019)

E(z)[+]/E(z)⁶⁰ is a suppressor | partially of abnormal size | adult stage phenotype of eya^cs/eya¹

(Tian et al., 2019)

E(z)[+]/E(z)⁶⁰ is a suppressor | partially of visible | adult stage phenotype of eya^cs/eya²

(Tian et al., 2019)

E(z)⁶⁰ is a suppressor of abnormal eye color phenotype of w^T81

(Netter et al., 1998)

E(z)⁶⁰ is a suppressor of visible phenotype of ct^pN2s

(Melnikova et al., 1996)

E(z)⁶⁰ is a suppressor of visible phenotype of ct^n2s

(Melnikova et al., 1996)

E(z)⁶⁰ is a suppressor of abnormal eye color phenotype of z¹

(Wu et al., 1989)

E(z)⁶⁰/E(z)⁶¹ is a suppressor of abnormal eye color phenotype of z¹

(Wu et al., 1989)

Other

Statement

Reference

E(z)⁶⁰, corto⁴⁴⁸ has visible | dominant phenotype

(Kodjabachian et al., 1998)

E(z)⁶⁰, corto⁴²⁰ has visible | dominant phenotype

(Kodjabachian et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

E(z)⁶⁰ has mesothoracic leg phenotype, enhanceable by dom¹⁴/dom[+]

(Ruhf et al., 2001)

Suppressed by

Statement

Reference

E(z)^Trm/E(z)⁶⁰ has adult prothoracic segment phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-1³

(Bajusz et al., 2001)

E(z)^Trm/E(z)⁶⁰ has adult abdominal segment 4 | ectopic phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-1³

(Bajusz et al., 2001)

E(z)^Trm/E(z)⁶⁰ has adult abdominal segment 5 phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-1³

(Bajusz et al., 2001)

E(z)^Trm/E(z)⁶⁰ has adult mesothoracic segment | ectopic phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-1³

(Bajusz et al., 2001)

E(z)^Trm/E(z)⁶⁰ has adult metathoracic segment phenotype, suppressible | partially by Su(var)2-1[+]/Su(var)2-1³

(Bajusz et al., 2001)

Enhancer of

Statement

Reference

E(z)[+]/E(z)⁶⁰ is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

E(z)⁶⁰ is an enhancer of phenotype of corto⁴⁴⁸

(Kodjabachian et al., 1998)

E(z)⁶⁰ is an enhancer of phenotype of corto⁴²⁰

(Kodjabachian et al., 1998)

E(z)⁶⁰ is an enhancer of phenotype of mxc^M1

(Docquier et al., 1996)

Suppressor of

Statement

Reference

E(z)[+]/E(z)⁶⁰ is a suppressor | partially of eye phenotype of eya^cs/eya¹

(Tian et al., 2019)

E(z)[+]/E(z)⁶⁰ is a suppressor | partially of eye phenotype of eya^cs/eya²

(Tian et al., 2019)

E(z)⁶⁰ is a suppressor of wing phenotype of ct^pN2s

(Melnikova et al., 1996)

E(z)⁶⁰ is a suppressor of wing phenotype of ct^n2s

(Melnikova et al., 1996)

E(z)⁶⁰ is a suppressor of phenotype of z¹

(Peterson et al., 1994, Jones and Gelbart, 1993, Jones and Gelbart, 1990)

E(z)⁶⁰ is a suppressor of phenotype of w^zl

(Peterson et al., 1994)

E(z)⁶⁰ is a suppressor of phenotype of w^zm

(Peterson et al., 1994)

NOT Suppressor of

Statement

Reference

E(z)[+]/E(z)⁶⁰ is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^UAS.cMa

(Moshkin et al., 2002)

Other

Statement

Reference

E(z)⁶⁰, corto⁴⁴⁸ has sex comb phenotype

(Kodjabachian et al., 1998)

E(z)⁶⁰, corto⁴²⁰ has sex comb phenotype

(Kodjabachian et al., 1998)

E(z)⁶⁰, corto⁴²⁰ has prothoracic tarsal segment 2 phenotype

(Kodjabachian et al., 1998)

E(z)⁶⁰, corto⁴⁴⁸ has prothoracic tarsal segment 2 phenotype

(Kodjabachian et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

E(z)⁶⁰/+ does not suppress the rough eye phenotype due to Scer\GAL4^ey.PH; asf1^Scer\UAS.cMa.

(Moshkin et al., 2002)

Weak suppressor of eye pigment phenotype of w^T81.

(Netter et al., 1998)

Hemizygous mxc^M1 males show weak homeotic phenotypes. Strong enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of E(z)⁶⁰.

(Saget et al., 1998)

Has no effect on the phenotypes of ct^2s, ct^4s and ct⁶, where the wing margin enhancer is completely blocked.

(Melnikova et al., 1996)

Dominant suppressor of z¹ eye colour: yellow eye colour darkens to an orange tan. E(z)⁶⁰/E(z)⁶¹ heterozygotes display extreme suppression of the z¹ eye colour.

(Wu et al., 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

E(z)⁵

(Phillips and Shearn, 1990)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

E(Z)^S1

(Rusch and Kaufman, 2000)

E(Z)Su301

(Netter et al., 1998)

E(z)⁶⁰

(Wicker-Thomas and Jallon, 2000)

E(z)^S1

(Tian et al., 2019, Belenkaya et al., 1998, Gindhart and Kaufman, 1995, Judd, 1995, Peterson et al., 1994, Jones and Gelbart, 1990, Wu et al., 1989)

E(z)^Su301

(Moshkin et al., 2002)

E(z)^s1

(Kapoun and Kaufman, 1995)

Su(z)301

(Docquier et al., 1996, Melnikova et al., 1996, Georgiev, 1994, Phillips and Shearn, 1990, Wu et al., 1989)

Su(z)³⁰¹

Name Synonyms

Secondary FlyBase IDs

References (33)

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