FlyBase Allele Report: Dmel\H[3]

General Information

Symbol

Dmel\H³

Species

D. melanogaster

Name

FlyBase ID

FBal0005294

Feature type

allele

Associated gene

Dmel\H

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Bang et al., 1991)

hypomorphic allele - genetic evidence

(Nagel et al., 2000)

Mutagen

spontaneous

(Bang et al., 1991)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Bang et al., 1991)

Description

Southern blots failed to find any molecular lesions in H region.

(Maier et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Maier et al., 1992, Bang et al., 1991)

visible (with H¹)

(Nagel et al., 2000)

visible | dominant

(Maier et al., 1992)

Phenotype Manifest In

eo neuron (with H¹)

(Nagel et al., 2000)

mechanosensory chaeta | adult stage

(Shukla et al., 2017)

sensory mother cell (with H¹)

(Nagel et al., 2000)

thecogen cell | ectopic (with H¹)

(Nagel et al., 2000)

tormogen cell | ectopic (with H¹)

(Nagel et al., 2000)

Detailed Description

Statement

Reference

H³ heterozygous adults display loss of one or more thoracic sensory bristles, as compared o controls.

(Shukla et al., 2017)

H³/H¹ flies have a loss of Sensory Organ Precursors (SOP), and thus in nearly bald pharate adults. Remaining SOPs mainly give rise to quadruple sockets.

(Nagel et al., 2000)

Recessive phenotypic effects. Bristle loss on head and notum and double socket phenotype.

(Bang et al., 1991)

Like H¹. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

H³ is a non-enhancer of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

H³ is a non-suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

H³ has mechanosensory chaeta | adult stage phenotype, enhanceable by Rbfox1^RNAi.UAS/Scer\GAL4^sca-109-68

(Shukla et al., 2017)

NOT Enhancer of

Statement

Reference

H³ is a non-enhancer of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Suppressor of

Statement

Reference

H³ is a suppressor of interommatidial bristle phenotype of Df(3R)3450/WASp¹

(Ben-Yaacov et al., 2001)

NOT Suppressor of

Statement

Reference

H³ is a non-suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

H³, Rbfox1^RNAi.UAS, Scer\GAL4^sca-109-68 has tormogen cell | adult stage phenotype

(Shukla et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

H³ heterozygous adults also expressing Rbfox1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^sca-109-68 exhibit an enhanced loss of thoracic sensory bristles and exhibit a significant amount of sockets instead of bristles, as compared to H³ heterozygotes.

(Shukla et al., 2017)

The loss of interommatidial bristles seen in WASp¹/Df(3R)3450 flies is almost completely suppressed by H³.

(Ben-Yaacov et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

518

H³/In(3R)C, Sb¹ e¹ l(3)e¹

Kyoto

105958

H³/In(3R)C, Sb¹ sprd¹ e¹ l(3)e¹

Notes on Origin

Discoverer

Sturtevant.

Comments

Strong H allele.

(Bang et al., 1991)

Phenotypic series of H alleles, progressing from strongest (amorphic) to weakest mutant phenotype: H^B79 = H⁸¹ >> H¹ = H⁹⁹ > H^bob > H^94a > H^88d > H^B8 > H² >= H³ > H^A120.

(Maier et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

H³

(Shukla et al., 2017, Morimoto et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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