FlyBase Allele Report: Dmel\retn[02535]

General Information

Symbol

Dmel\retn⁰²⁵³⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0008003

Feature type

allele

Associated gene

Dmel\retn

Associated Insertion(s)

P{PZ}retn⁰²⁵³⁵

Carried in Construct

Also Known As

dri⁷, l(2)02535

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}retn⁰²⁵³⁵

Cytology

Description

The P{PZ} insertion is upstream of the first exon of the retn gene.

(Ditch et al., 2005)

P{PZ} insertion 471bp upstream of the retn transcription start site.

(Shandala et al., 1999)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:23,632,588..23,632,588 [+]

(Ditch et al., 2005, Shandala et al., 1999, Spradling et al., 1999, Harvie et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999, Harvie et al., 1998)

lethal - all die during embryonic stage | recessive

(Shandala et al., 1999)

partially lethal - majority die

some die during embryonic stage | recessive

(Shandala et al., 1999)

Phenotype Manifest In

embryonic/larval hindgut | embryonic stage

(Shandala et al., 1999)

Detailed Description

Statement

Reference

Both zygotic and germline clone homozygous embryos have a normal pattern of cuticle structures. retn-expressing cells in the hindgut are disordered in homozygous embryos.

(Shandala et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

retn⁰²⁵³⁵/retn[+] is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

retn⁰²⁵³⁵/retn[+] is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

retn^GAL4

(Shandala et al., 1999)

retn⁰⁵⁰⁹⁶

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11200

cn¹ P{PZ}retn⁰²⁵³⁵/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: Dcp-1⁰¹⁸⁶². Complements: apt⁰³⁰⁴¹. Complements: apt⁰⁶³⁶⁹. Complements: apt⁰⁷⁰¹⁰. Complements: apt⁰⁹⁰⁴⁹. Complements: eIF6^k13214.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

dri⁰²⁵³⁵

dri⁷

(Ditch et al., 2005, Shandala et al., 1999)

l(2)02535

(Shandala et al., 1999, Spradling et al., 1999)

l(2)02535⁰²⁵³⁵

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

retn⁰²⁵³⁵

(Christensen et al., 2009.5.6, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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