FlyBase Allele Report: Dmel\ck[07130]

(Rudrapatna et al., 2014, Todi et al., 2005, Kiehart et al., 2004, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of auditory system disease

CEA

(Todi et al., 2005)

model of autosomal recessive nonsyndromic deafness 2

CEC with ck¹³

(Todi et al., 2008)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Johnston's organ & dendritic cap cell

(Todi et al., 2005)

Johnston's organ & dendritic cap cell (with ck¹³)

(Todi et al., 2005)

Johnston's organ & scolopidium

(Todi et al., 2005)

Johnston's organ & scolopidium (with ck¹³)

(Todi et al., 2005)

wing hair | increased number

(Winter et al., 2001)

Detailed Description

Statement

Reference

ck⁰⁷¹³⁰ homozygote and ck¹³/ck⁰⁷¹³⁰ transheterozygote flies show a significantly reduced response to the pulse song, as measured by sound-evoked potentials from the antennal nerve. The morphology of the Johnston's organ is defective in these mutants, and shows apical detachment of the scolopidia. The dendritic cap of the scolopidium often fails to enclose one of the cilia and is sometimes divided into several compartments. Scolopidial basal attachments to the a2 cuticle are not affected. Expression of ck^{tail.Scer\UAS.T:Avic\GFP} in scolopale cells driven by Scer\GAL4^sqh.PW, or in neurons driven by Scer\GAL4^elav-C155, leads to a reduction in sound-evoked potentials from ck¹³/ck⁰⁷¹³⁰ flies.

(Todi et al., 2005)

Homozygotes have a multiple wing hair phenotype.

(Winter et al., 2001)

Weak ck allele.

(Ashburner et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ck⁰⁷¹³⁰ has visible | recessive phenotype, enhanceable by sqh^E20.E21

(Winter et al., 2001)

NOT Enhanced by

Statement

Reference

ck⁰⁷¹³⁰ has visible | recessive phenotype, non-enhanceable by sqh^{A20.A21.Tag:FLAG}

(Winter et al., 2001)

Suppressor of

Statement

Reference

ck⁰⁷¹³⁰/ck[+] is a suppressor | partially of visible phenotype of Scer\GAL4^hs.PB, tow^UAS.cCa

(Chung et al., 2007)

ck⁰⁷¹³⁰ is a suppressor of visible | recessive phenotype of dsh¹

(Winter et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

ck⁰⁷¹³⁰ has wing hair | increased number phenotype, enhanceable by sqh^E20.E21

(Winter et al., 2001)

NOT Enhanced by

Statement

Reference

ck⁰⁷¹³⁰ has wing hair | increased number phenotype, non-enhanceable by sqh^{A20.A21.Tag:FLAG}

(Winter et al., 2001)

Suppressor of

Statement

Reference

ck⁰⁷¹³⁰/ck[+] is a suppressor | partially of wing hair | increased number phenotype of Scer\GAL4^hs.PB, tow^UAS.cCa

(Chung et al., 2007)

ck⁰⁷¹³⁰ is a suppressor of wing hair | increased number phenotype of dsh¹

(Winter et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The multiple wing hair phenotype caused by expression of tow^Scer\UAS.cCa under the control of Scer\GAL4^hs.PB using heat shock at 24 hours after puparium formation is partially suppressed by one copy of ck⁰⁷¹³⁰.

(Chung et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

ck^unspecified

(Kiehart et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12337

cn¹ P{PZ}ck⁰⁷¹³⁰/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Associated with: a secondary lethal lesion on the chromosome; ck⁰⁷¹³⁰/Df(2L)osp29 hemizygotes are viable, suggesting that the lethality of the chromosome is not due to the P{PZ}ck⁰⁷¹³⁰ insertion.

(Kiehart et al., 2004)

Comments

Most excisions of the P{PZ} element revert the weak ck phenotype.

(Ashburner et al., 1999)

Excision of the P{PZ} element can revert the mutant phenotype.

(Ashburner et al., 1999)

Excision of the P{PZ} insertion can revert the phenotype to wild type.

(Kiehart et al., 2004)

Complements: l(2)34Db^AS1. Complements: CG15269⁰⁵⁴⁴¹. Complements: esg⁰⁵⁷³⁰. Complements: esg⁰⁷⁰⁸². Complements: l(2)35Bd¹⁰⁴⁰⁸. Complements: Su(H)^k07904. Complements: l(2)35Bg^k10011.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

PZ07130

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

ck⁰⁷¹³⁰

(Rudrapatna et al., 2014, Todi et al., 2008, Chung et al., 2007)

ck^PZ

(Sallee et al., 2021)

l(2)07130

(Spradling et al., 1999)

l(2)07130⁰⁷¹³⁰

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

Open Close