FlyBase Allele Report: Dmel\dsh[1]

General Information

Symbol

Dmel\dsh¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003138

Feature type

allele

Associated gene

Dmel\dsh

Associated Insertion(s)

Carried in Construct

Also Known As

dsh1

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

methyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Krasnow et al., 1995)

Mutagen

methyl methanesulfonate

(Perrimon and Mahowald, 1987, Fahmy and Fahmy, 1959)

Progenitor genotype

Cytology

Description

Amino acid replacement: K417M.

(Penton et al., 2002, Axelrod et al., 1998)

Amino acid replacement: K417M. K417 falls in the DEP domain.

(Boutros et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,357,603..11,357,603 [+]

Nucleotide change:

A11357603T

Amino acid change:

K417M | dsh-PA

Reported amino acid change:

K417M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Axelrod et al., 1998, Boutros et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal recessive intellectual developmental disorder

modeled by Nab2^ex3

(Corgiat et al., 2022)

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity

(Strutt et al., 2006)

abnormal mitotic cell cycle | P-stage

(Ségalen et al., 2010)

abnormal neuroanatomy

(Gombos et al., 2015)

abnormal neuroanatomy | adult stage

(Dollar et al., 2016)

abnormal neuroanatomy | dominant

(Srahna et al., 2006)

abnormal neuroanatomy | larval stage | conditional

(Dominicci-Cotto et al., 2024)

abnormal neuroanatomy | P-stage

(Han et al., 2020)

abnormal neuroanatomy | third instar larval stage

(Matsubara et al., 2011)

abnormal planar polarity

(Weber et al., 2012, Yanfeng et al., 2011, Chung et al., 2007, Rawls et al., 2007, Bartscherer et al., 2006, Jenny et al., 2005, Lee and Treisman, 2004, Stronach and Perrimon, 2002, Axelrod, 2001, Rousset et al., 2001, Axelrod et al., 1998, Taylor et al., 1998)

abnormal planar polarity (with dsh³)

(Penton et al., 2002)

abnormal planar polarity | adult stage

(Mieszczanek et al., 2022, Dollar et al., 2016)

abnormal planar polarity | adult stage | male

(Domingos et al., 2019)

abnormal planar polarity | adult stage | recessive

(Shami Shah et al., 2019)

abnormal planar polarity | cell autonomous | somatic clone

(Lee and Adler, 2002)

abnormal planar polarity | recessive

(Winter et al., 2001, Cooper and Bray, 1999, Boutros et al., 1998)

abnormal size | adult stage | male limited

(Steinhauer et al., 2019)

decreased fecundity | female

(Cohen et al., 2002)

female sterile

(Zhimulev et al., 1987, Fahmy and Fahmy, 1959)

fertile

(Cohen et al., 2002, Wong and Adler, 1993)

male fertile

(Fahmy and Fahmy, 1959)

male semi-fertile

(Steinhauer et al., 2019)

partially lethal - majority live

(Penton et al., 2002)

viable

(Dollar et al., 2016, Krasnow et al., 1995, Wong and Adler, 1993)

viable (with dsh³)

(Penton et al., 2002)

viable | male

(Fahmy and Fahmy, 1959)

visible

(Capilla et al., 2012, Chung et al., 2007, Speck et al., 2003, Stronach and Perrimon, 2002, Fahmy and Fahmy, 1959)

visible | adult stage

(Mieszczanek et al., 2022)

visible | adult stage | recessive

(Shami Shah et al., 2019)

visible | recessive

(Winter et al., 2001, Bishop et al., 1999, Cooper and Bray, 1999)

Phenotype Manifest In

adult mushroom body alpha-lobe

(Gombos et al., 2015)

adult mushroom body alpha-lobe | adult stage

(Dollar et al., 2016)

adult mushroom body beta-lobe

(Gombos et al., 2015)

adult mushroom body beta-lobe | adult stage

(Dollar et al., 2016)

adult thoracic mechanosensory chaeta

(Mieszczanek et al., 2022)

adult thorax & microchaeta

(Fahmy and Fahmy, 1959)

axon & dorsal cluster neuron

(Srahna et al., 2006)

axon | adult stage

(Dollar et al., 2016)

border follicle cell

(Bastock and Strutt, 2007)

chaeta

(Penton et al., 2002)

chaeta (with dsh³)

(Penton et al., 2002)

egg chamber (with dsh⁴)

(Cohen et al., 2002)

embryonic/larval neuromuscular junction | larval stage | conditional

(Dominicci-Cotto et al., 2024)

embryonic/larval tracheal dorsal trunk

(Chung et al., 2009)

external sensory organ precursor cell I

(Gho and Schweisguth, 1998)

eye

(Cooper and Bray, 1999, Theisen et al., 1994, Fahmy and Fahmy, 1959)

femur

(Mieszczanek et al., 2022)

germarium (with dsh⁴)

(Cohen et al., 2002)

interommatidial bristle

(Shami Shah et al., 2019, Theisen et al., 1994)

larval multidendritic class IV neuron

(Matsubara et al., 2011)

leg

(Capilla et al., 2012)

leg & joint

(Bishop et al., 1999)

leg joint | ectopic

(Mieszczanek et al., 2022, Capilla et al., 2012, Bishop et al., 1999)

macrochaeta

(Bartscherer et al., 2006, Theisen et al., 1994, Fahmy and Fahmy, 1959)

medulla | P-stage

(Han et al., 2020)

mesothoracic femoral bract

(Theisen et al., 1994)

mesothoracic tergum & trichome

(Stronach and Perrimon, 2002)

mesothoracic tibial bract

(Theisen et al., 1994)

metathoracic femoral bract

(Theisen et al., 1994)

metathoracic tibial bract

(Theisen et al., 1994)

microchaeta

(Theisen et al., 1994)

ommatidium

(Dollar et al., 2016, Weber et al., 2012, Fetting et al., 2009, Rawls et al., 2007, Jenny et al., 2005, Cooper and Bray, 1999, Boutros et al., 1998, Fahmy and Fahmy, 1959)

ommatidium | male

(Domingos et al., 2019)

ovarian sheath (with dsh⁴)

(Cohen et al., 2002)

ovary (with dsh⁴)

(Cohen et al., 2002)

prothoracic femoral bract

(Theisen et al., 1994)

prothoracic tibial bract

(Theisen et al., 1994)

sensory mother cell | P-stage

(Ségalen et al., 2010)

sperm individualization complex

(Steinhauer et al., 2019)

spindle | P-stage

(Ségalen et al., 2010)

testis

(Steinhauer et al., 2019)

thoracic tergum

(Shami Shah et al., 2019)

trichome

(Shami Shah et al., 2019, Penton et al., 2002)

trichome (with dsh³)

(Penton et al., 2002)

wing

(Rousset et al., 2001, Theisen et al., 1994, Fahmy and Fahmy, 1959)

wing | pupal stage

(Pataki et al., 2010)

wing blade dorsal compartment | anterior

(Doyle et al., 2008)

wing hair

(Mieszczanek et al., 2022, Shami Shah et al., 2019, Chung et al., 2007, Strutt et al., 2006, Penton et al., 2002, Stronach and Perrimon, 2002, Winter et al., 2001, Taylor et al., 1998, Wong and Adler, 1993)

wing hair | cell autonomous | somatic clone

(Lee and Adler, 2002)

wing hair | increased number

(Chung et al., 2007, Lee and Treisman, 2004, Speck et al., 2003, Winter et al., 2001)

Detailed Description

Statement

Reference

dsh¹ males show ommatidial chirality phenotypes - planar cell polarity defects -, such as symmetric R3/R4 or R4/R4 configurations.

(Domingos et al., 2019)

dsh¹/dsh¹ flies display misoriented hair patterns on the wing, thorax and eyes, while heterozygotes exhibit phenotypes similar to wild-type controls.

(Shami Shah et al., 2019)

dsh¹ males exhibit reduced fertility in single male crosses (the number of single male crosses that fail to produce offspring is higher than controls) while the number of offspring generated by fertile males is not different when compared to controls.

dsh¹ males have short testes with significantly fewer waste bags, fewer normal individualization complexes (ICs) and more abnormal ICs when compared to controls.

(Steinhauer et al., 2019)

dsh¹/Y flies are viable and have ommatidial rotation defects (planar cell polarity-like defects) in the eye, as well as mushroom body axon growth and guidance defects.

(Dollar et al., 2016)

Dorsal cluster neurons axon branching at the third branching point is unaffected in dsh¹ mutant males.

(Vandewalle et al., 2013)

Mutants have ectopic joints in the leg.

(Capilla et al., 2012)

The majority of sensory organs of the leg of mutant flies project protrusions indistinguishable in morphology and orientation from those of wild type at 24 hours after puparium formation. However, improperly positioned bract cells and misdirected protrusions from the sensory organs are observed at similar, low frequencies (2.3 +/- 1.4% and 3.0 +/- 1.6%, respectively) and at similar but higher frequencies in the tarsi (8.5 +/- 2.9% and 17.1 +/- 3.3%, respectively) of mutant flies. These errors are not seen in wild type.

(Peng et al., 2012)

dsh¹ hemizygotes display ommatidial planar cell polarity (PCP) defects in the eye.

(Weber et al., 2012)

The number of dendritic branches is decreased in the class IV da neurons of homozygous larvae.

(Matsubara et al., 2011)

dsh¹ mutants display PCP defects.

(Yanfeng et al., 2011)

dsh¹ maternal/zygotic mutants show little to no epidermal cell shape and denticle alignment defects.

(Kaplan and Tolwinski, 2010)

In wild-type wings, the ratio of non-hexagonally shaped cells relative to hexagonally shaped cells is around 11%, whereas in dsh¹ homozygous mutant wings this ratio increases to 28%.

(Pataki et al., 2010)

In dsh¹/dsh¹ pupal sensory mother cells, mitotic spindle orientation is parallel to the plane of the epithelium; the orientation of mitotic spindle is also randomized relative to the anterior-posterior axis.

(Ségalen et al., 2010)

Homozygous stage 16 embryos have longer dorsal trunks than normal.

(Chung et al., 2009)

Many dsh¹ ommatidia mis-rotate; the variance (s.d.) in degree of rotation is greater than in wild type in adult eyes.

(Fetting et al., 2009)

Wing membrane ridges in the anterior region of the wings of wild-type flies have an anterior-posterior orientation, but have a proximal-distal orientation in a dsh¹ mutant.

(Doyle et al., 2008)

Border cell clusters from dsh¹ mutants show an average of 38.4 actin protrusions, reduced compared to the average of 94.8 in wild-type clusters.

(Bastock and Strutt, 2007)

Hemizygous males have polarity defects in the wing such as swirling hair patterns and multiple wing hairs.

(Chung et al., 2007)

Hemizygotes show defects in ommatidial polarity.

(Rawls et al., 2007)

The orientation of bristles on the nota of dsh¹ flies is disturbed.

(Bartscherer et al., 2006)

The average number of dorsal cluster neuron axons that cross between the lobula and the medulla is reduced from the wild-type number of 11.7 to 7.4 in the brains of dsh¹/+ mutants. In dsh¹ homozygotes the number is further reduced to 4.7.

(Srahna et al., 2006)

dsh¹ wing hairs show planar polarity defects.

(Strutt et al., 2006)

Flies have a planar cell polarity phenotype in the eye.

(Jenny et al., 2005)

dsh¹/Y mutants have wings with altered planar polarity that contain multiple wing hairs.

(Lee and Treisman, 2004)

Cells in the wing produce double hairs at a frequency of 6.3 +/- 1.0% in dsh¹ flies.

(Speck et al., 2003)

Females exhibit reduced fecundity. dsh¹/dsh⁴ heterozygotes show an ovary phenotype like that of Wnt4 mutants, though with reduced penetrance, with germaria flopped over the older egg chambers due to inadequate ovary sheath.

(Cohen et al., 2002)

Mutant clones in the wing show disruption of polarity, as indicated by wing hairs.

(Lee and Adler, 2002)

dsh¹/Y and dsh¹/dsh³ flies have planar polarity defects, resulting in an aberrant orientation of bristles and hairs.

(Penton et al., 2002)

dsh¹ mutants show disrupted orientation of wing hairs and random orientation of hairs on the notum.

(Stronach and Perrimon, 2002)

Mutant animals have a mutant planar cell polarity phenotype.

(Axelrod, 2001)

12% of cells in a defined region of the wing (the ventral surface of the proximal-anterior region) have multiple hairs in hemizygous males. Ectopic F-actin prehairs are seen in pupal wing cells. A hair misorientation phenotype is seen.

(Winter et al., 2001)

Proximal-distal planar polarity is roughly normal at the distal wing tip in the dorsal epidermis of mutant flies.

(Rulifson et al., 2000)

Legs develop ectopic joints in homozygous flies. These ectopic joints have reversed orientation of the "ball and socket" of the joint and are formed proximal to the normal joints.

(Bishop et al., 1999)

dsh¹ flies have rough eyes and only 55% of ommatidia have correct rotation and chirality.

(Cooper and Bray, 1999)

Does not affect the eye polarity phenotype of N^act.sev.

(Fanto and Mlodzik, 1999)

The dsh¹ tissue polarity phenotype in the wing is suppressed by expression of dsh^hs.PA.

(Axelrod et al., 1998)

Eyes show disruption of ommatidial arrangement in 55.5% of ommatidia, with random or no chirality and misrotations of single ommatidia. The equator is not evident.

(Boutros et al., 1998)

Mutants exhibit randomly oriented pI divisions in the epithelial plane. The socket, shaft and pIIb cells are always localised in the region of the cell in contact with pIIb. The socket cells always occupies an eccentric position.

(Gho and Schweisguth, 1998)

Homozygotes display a strong tissue polarity phenotype. Homozygotes in combination with P{hsfzI} heat shocked to induce a strong hsfz-late phenotype exhibit suppression of the MHC phenotype.

(Krasnow et al., 1995)

Sections of dsh¹-dsh³ double mutant eyes show a disturbed ommatidial polarity within each ommatidium having the normal arrangement of photoreceptor cells.

(Zheng et al., 1995)

All cells in which planar polarity is evident are affected by dsh mutations. Leg bracts are induced in the wrong position relative to the bristle. Legs show extra mirror image duplications of tarsal joints. Rough eye phenotype reflects abnormal facet packing. Antidromic illumination reveals that although each photoreceptor cluster has the normal trapezoidal arrangement the clusters are misoriented reflecting an abnormal polarity of the whole ommatidium. Some ommatidia are rotated from their normal orientation but have normal handedness. Others are reversed in the A/P or D/V axis.

(Theisen et al., 1994)

Most wing cells of homozygous flies form a single hair. Homozygous flies have disruptions in the pattern of wing hair polarity. The prehair initiation site is moved to near the cell centre in pupal wing cells. Double mutants of dsh¹ with in¹, fy² or mwh¹ resemble in¹, fy² or mwh¹ single mutants respectively.

(Wong and Adler, 1993)

No maternal effect. Hemizygous males and homozygous females have poor viability due to a second site mutation, hemizygous females are fully viable.

(Perrimon and Mahowald, 1987)

Thoracic hairs deranged, males have poor fertility.

(Zhimulev et al., 1987)

Thoracic microchaetae are completely deranged. One or more macrochaetae are abnormally curved. The wings are abnormally inserted, and are usually divergent or slightly upheld. Occasionally one wing is completely deformed, small and blistered. The eyes are ellipsoid with some derangement of the ommatidia.

(Fahmy and Fahmy, 1959)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dsh¹ has abnormal neuroanatomy phenotype, enhanceable by DAAM[+]/DAAM^Ex1

(Gombos et al., 2015)

dsh¹ has abnormal planar polarity phenotype, enhanceable by CG15283^GD13108/Scer\GAL4^hs.2sev

(Weber et al., 2012)

dsh¹ has abnormal planar polarity phenotype, enhanceable by bdg[+]/bdg^GMREP

(Rawls et al., 2007)

dsh¹ has abnormal planar polarity phenotype, enhanceable by bdg¹⁶⁴/bdg[+]

(Rawls et al., 2007)

dsh¹ has abnormal neuroanatomy phenotype, enhanceable by Wnt5⁴⁰⁰/Wnt5[+]

(Srahna et al., 2006)

dsh¹ has abnormal neuroanatomy phenotype, enhanceable by bsk^DN.UAS/Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ has visible | recessive phenotype, enhanceable by sqh^A21.Tag:FLAG

(Winter et al., 2001)

dsh¹ has visible | recessive phenotype, enhanceable by Rok²

(Winter et al., 2001)

dsh¹ has visible | recessive phenotype, enhanceable by zip[+]/zip¹

(Winter et al., 2001)

NOT Enhanced by

Statement

Reference

dsh¹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

dsh¹ has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

dsh¹ has abnormal planar polarity | adult stage phenotype, non-enhanceable by Frl[+]/Frl^ExK62

(Dollar et al., 2016)

dsh¹ has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by Frl[+]/Frl^Ex88

(Dollar et al., 2016)

Suppressed by

Statement

Reference

dsh¹ has abnormal planar polarity | male | adult stage phenotype, suppressible by numb[+]/numb²

(Domingos et al., 2019)

dsh¹ has abnormal planar polarity | male | adult stage phenotype, suppressible by numb[+]/numb¹⁵

(Domingos et al., 2019)

dsh¹ has visible phenotype, suppressible by Rab5^UAS.cEa/Scer\GAL4^ap-md544

(Capilla et al., 2012)

dsh¹ has visible phenotype, suppressible by Scer\GAL4^ap-md544/dx^ΔNBS.UAS

(Capilla et al., 2012)

dsh¹ has abnormal neuroanatomy phenotype, suppressible by Rac1^N17.UAS/Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ has abnormal neuroanatomy phenotype, suppressible by hep^UAS.cBa/Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ has abnormal neuroanatomy phenotype, suppressible by btl^DN.UAS/Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ has abnormal planar polarity phenotype, suppressible by pk[+]/pk¹

(Jenny et al., 2005)

dsh¹ has visible phenotype, suppressible by Moe^G0323/Moe[+]

(Speck et al., 2003)

dsh¹ has visible | recessive phenotype, suppressible by ck¹³

(Winter et al., 2001)

dsh¹ has visible | recessive phenotype, suppressible by ck⁰⁷¹³⁰

(Winter et al., 2001)

dsh¹ has visible | recessive phenotype, suppressible by sqh^A20.E21

(Winter et al., 2001)

dsh¹ has visible | recessive phenotype, suppressible by sqh^E20.E21

(Winter et al., 2001)

dsh¹ has visible | recessive phenotype, suppressible by sqh^E21.Tag:FLAG

(Winter et al., 2001)

dsh¹ has visible | recessive phenotype, suppressible by Rok^αTub84B.PW

(Winter et al., 2001)

dsh¹ has abnormal planar polarity | recessive phenotype, suppressible by Scer\GAL4^salm-459.2/E(spl)mβ-HLH^UAS.cdCa

(Cooper and Bray, 1999)

dsh¹ has visible | recessive phenotype, suppressible by Scer\GAL4^salm-459.2/E(spl)mβ-HLH^UAS.cdCa

(Cooper and Bray, 1999)

NOT suppressed by

Statement

Reference

dsh¹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

dsh¹ has abnormal planar polarity | adult stage phenotype, non-suppressible by Frl[+]/Frl^ExK62

(Dollar et al., 2016)

dsh¹ has visible phenotype, non-suppressible by Scer\GAL4^ap-md544/dx^UAS.cMa

(Capilla et al., 2012)

dsh¹ has visible phenotype, non-suppressible by Scer\GAL4^ap-md544/dx^ΔPRM.UAS

(Capilla et al., 2012)

dsh¹ has visible phenotype, non-suppressible by Scer\GAL4^ap-md544/dx^mRZF.UAS

(Capilla et al., 2012)

dsh¹ has abnormal planar polarity phenotype, non-suppressible by Mbs^T541/Mbs[+]

(Lee and Treisman, 2004)

dsh¹ has abnormal planar polarity phenotype, non-suppressible by Rok^αTub84B.PW

(Winter et al., 2001)

dsh¹ has abnormal planar polarity phenotype, non-suppressible by sqh^E20.E21

(Winter et al., 2001)

Enhancer of

Statement

Reference

dsh¹/dsh¹ is an enhancer of visible | adult stage phenotype of meru¹

(Banerjee et al., 2017)

dsh¹/dsh[+] is an enhancer of abnormal neuroanatomy | adult stage | dominant phenotype of tap^Gal4

(Yuan et al., 2016)

dsh¹/dsh[+] is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex1

(Gombos et al., 2015)

dsh¹ is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^ato.3.6, bsk^DN.UAS

(Srahna et al., 2006)

dsh¹/dsh[+] is an enhancer of abnormal neuroanatomy phenotype of Wnt5⁴⁰⁰

(Srahna et al., 2006)

dsh¹/dsh[+] is an enhancer of abnormal cell polarity phenotype of fz²⁰/fz¹⁹

(Strutt et al., 2006)

dsh¹/dsh[+] is an enhancer of abnormal planar polarity phenotype of dgo²⁶⁹

(Jenny et al., 2005)

dsh¹ is an enhancer of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

dsh¹ is an enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

dsh¹ is an enhancer of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

dsh¹ is an enhancer of abnormal cell polarity phenotype of fz²⁰/fz¹⁹

(Strutt and Strutt, 2003)

NOT Enhancer of

Statement

Reference

dsh¹ is a non-enhancer of abnormal planar polarity | adult stage | somatic clone - Minute background phenotype of Frl^Ex83

(Dollar et al., 2016)

dsh¹ is a non-enhancer of abnormal planar polarity | adult stage | somatic clone - Minute background phenotype of Frl^ExK62

(Dollar et al., 2016)

dsh¹/dsh[+] is a non-enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

dsh¹/dsh[+] is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dsh¹/dsh[+] is a non-enhancer of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

dsh¹ is a non-enhancer of abnormal neuroanatomy phenotype of Rac1^N17.UAS, Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

dsh¹/dsh[+] is a suppressor | partially of increased mortality during development phenotype of Nab2^ex3

(Lee et al., 2020)

dsh¹ is a suppressor | partially of abnormal neuroanatomy phenotype of Scer\GAL4^ey-OK107, Vang^UAS.mGFP6

(Gombos et al., 2015)

dsh¹ is a suppressor | partially of abnormal neuroanatomy phenotype of Scer\GAL4^ey-OK107, Wnt5^UAS.cFa

(Gombos et al., 2015)

dsh¹/dsh[+] is a suppressor of abnormal planar polarity phenotype of bdg^GMREP

(Rawls et al., 2007)

dsh¹/dsh[+] is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^ato.3.6, btl^DN.UAS

(Srahna et al., 2006)

dsh¹/dsh[+] is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Jenny et al., 2005)

dsh¹ is a suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of fz²³

(Lee and Adler, 2002)

dsh¹/dsh[+] is a suppressor of visible | heat sensitive phenotype of fz^I.hs

(Winter et al., 2001)

NOT Suppressor of

Statement

Reference

dsh¹ is a non-suppressor of abnormal planar polarity | adult stage | somatic clone - Minute background phenotype of Frl^Ex83

(Dollar et al., 2016)

dsh¹ is a non-suppressor of abnormal planar polarity | adult stage | somatic clone - Minute background phenotype of Frl^ExK62

(Dollar et al., 2016)

dsh¹/dsh[+] is a non-suppressor of abnormal neuroanatomy phenotype of DAAM^C.UASp, Scer\GAL4^ey-OK107

(Gombos et al., 2015)

dsh¹/dsh[+] is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

dsh¹/dsh[+] is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dsh¹/dsh[+] is a non-suppressor of abnormal cell polarity phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

dsh¹ is a non-suppressor of abnormal neuroanatomy phenotype of Rac1^N17.UAS, Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

dsh¹ is a non-suppressor of abnormal planar polarity | somatic clone | cell autonomous phenotype of fz²³

(Lee and Adler, 2002)

dsh¹ is a non-suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of fz²³

(Lee and Adler, 2002)

dsh¹ is a non-suppressor of visible phenotype of Scer\GAL4^71B, fz::fz2^{fz2CRD.UAS.Tag:MYC}

(Rulifson et al., 2000)

Other

Statement

Reference

Rho1^72O, dsh¹ has visible | adult stage phenotype

(Mieszczanek et al., 2022)

dsh¹/dsh[+], kmr² has visible | adult stage phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr² has abnormal planar polarity | adult stage phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr¹ has visible | adult stage phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr¹ has abnormal planar polarity | adult stage phenotype

(Shami Shah et al., 2019)

Rac1^J11/Rac1[+], dsh¹ has abnormal neuroanatomy phenotype

(Gombos et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

dsh¹ has adult mushroom body alpha-lobe phenotype, enhanceable by DAAM[+]/DAAM^Ex1

(Gombos et al., 2015)

dsh¹ has adult mushroom body beta-lobe phenotype, enhanceable by DAAM[+]/DAAM^Ex1

(Gombos et al., 2015)

dsh¹ has ommatidium phenotype, enhanceable by CG15283^GD13108/Scer\GAL4^hs.2sev

(Weber et al., 2012)

dsh¹ has ommatidium phenotype, enhanceable by ed[+]/ed^1X5

(Fetting et al., 2009)

dsh¹ has ommatidium phenotype, enhanceable by bdg[+]/bdg^GMREP

(Rawls et al., 2007)

dsh¹ has ommatidium phenotype, enhanceable by bdg¹⁶⁴/bdg[+]

(Rawls et al., 2007)

dsh¹ has axon & dorsal cluster neuron phenotype, enhanceable by Wnt5⁴⁰⁰/Wnt5[+]

(Srahna et al., 2006)

dsh¹ has axon & dorsal cluster neuron phenotype, enhanceable by bsk^DN.UAS/Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ has wing hair | increased number phenotype, enhanceable by sqh^A21.Tag:FLAG

(Winter et al., 2001)

dsh¹ has wing hair | increased number phenotype, enhanceable by Rok²

(Winter et al., 2001)

dsh¹ has wing hair | increased number phenotype, enhanceable by zip[+]/zip¹

(Winter et al., 2001)

NOT Enhanced by

Statement

Reference

dsh¹ has ommatidium phenotype, non-enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

dsh¹ has axon | adult stage phenotype, non-enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

dsh¹ has adult mushroom body beta-lobe | adult stage phenotype, non-enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

dsh¹ has adult mushroom body alpha-lobe | adult stage phenotype, non-enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

dsh¹ has ommatidium phenotype, non-enhanceable by Frl[+]/Frl^ExK62

(Dollar et al., 2016)

dsh¹ has axon | adult stage phenotype, non-enhanceable by Frl[+]/Frl^Ex88

(Dollar et al., 2016)

dsh¹ has adult mushroom body beta-lobe | adult stage phenotype, non-enhanceable by Frl[+]/Frl^Ex88

(Dollar et al., 2016)

dsh¹ has adult mushroom body alpha-lobe | adult stage phenotype, non-enhanceable by Frl[+]/Frl^Ex88

(Dollar et al., 2016)

dsh¹ has phenotype, non-enhanceable by Gli^dv5

(Venema et al., 2004)

Suppressed by

Statement

Reference

dsh¹ has ommatidium | male phenotype, suppressible by numb[+]/numb¹⁵

(Domingos et al., 2019)

dsh¹ has ommatidium | male phenotype, suppressible by numb[+]/numb²

(Domingos et al., 2019)

dsh¹ has leg joint | ectopic phenotype, suppressible by Rab5^UAS.cEa/Scer\GAL4^ap-md544

(Capilla et al., 2012)

dsh¹ has leg phenotype, suppressible by Rab5^UAS.cEa/Scer\GAL4^ap-md544

(Capilla et al., 2012)

dsh¹ has leg joint | ectopic phenotype, suppressible by Scer\GAL4^ap-md544/dx^ΔNBS.UAS

(Capilla et al., 2012)

dsh¹ has leg phenotype, suppressible by Scer\GAL4^ap-md544/dx^ΔNBS.UAS

(Capilla et al., 2012)

dsh¹ has axon & dorsal cluster neuron phenotype, suppressible by Rac1^N17.UAS/Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ has axon & dorsal cluster neuron phenotype, suppressible by hep^UAS.cBa/Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ has axon & dorsal cluster neuron phenotype, suppressible by btl^DN.UAS/Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ has ommatidium phenotype, suppressible by pk[+]/pk¹

(Jenny et al., 2005)

dsh¹ has wing hair | increased number phenotype, suppressible by Mbs^T541/Mbs[+]

(Lee and Treisman, 2004)

dsh¹ has wing hair | increased number phenotype, suppressible by Moe^G0323/Moe[+]

(Speck et al., 2003)

dsh¹ has wing hair | increased number phenotype, suppressible by ck¹³

(Winter et al., 2001)

dsh¹ has wing hair | increased number phenotype, suppressible by Rok^αTub84B.PW

(Winter et al., 2001)

dsh¹ has wing hair | increased number phenotype, suppressible by ck⁰⁷¹³⁰

(Winter et al., 2001)

dsh¹ has wing hair | increased number phenotype, suppressible by sqh^A20.E21

(Winter et al., 2001)

dsh¹ has wing hair | increased number phenotype, suppressible by sqh^E20.E21

(Winter et al., 2001)

dsh¹ has wing hair | increased number phenotype, suppressible by sqh^E21.Tag:FLAG

(Winter et al., 2001)

dsh¹ has eye phenotype, suppressible by Rac1^hs.sev

(Fanto et al., 2000)

dsh¹ has ommatidium phenotype, suppressible by Rac1^hs.sev

(Fanto et al., 2000)

dsh¹ has ommatidium phenotype, suppressible by Scer\GAL4^salm-459.2/E(spl)mβ-HLH^UAS.cdCa

(Cooper and Bray, 1999)

dsh¹ has eye phenotype, suppressible by Scer\GAL4^salm-459.2/E(spl)mβ-HLH^UAS.cdCa

(Cooper and Bray, 1999)

dsh¹ has phenotype, suppressible by Jra^hs.sev

(Boutros et al., 1998)

dsh¹ has phenotype, suppressible by Rho1^V14.sev

(Boutros et al., 1998)

NOT suppressed by

Statement

Reference

dsh¹ has ommatidium phenotype, non-suppressible by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

dsh¹ has ommatidium phenotype, non-suppressible by Frl[+]/Frl^ExK62

(Dollar et al., 2016)

dsh¹ has leg joint | ectopic phenotype, non-suppressible by Scer\GAL4^ap-md544/dx^UAS.cMa

(Capilla et al., 2012)

dsh¹ has leg joint | ectopic phenotype, non-suppressible by Scer\GAL4^ap-md544/dx^ΔPRM.UAS

(Capilla et al., 2012)

dsh¹ has leg joint | ectopic phenotype, non-suppressible by Scer\GAL4^ap-md544/dx^mRZF.UAS

(Capilla et al., 2012)

dsh¹ has leg phenotype, non-suppressible by Scer\GAL4^ap-md544/dx^UAS.cMa

(Capilla et al., 2012)

dsh¹ has leg phenotype, non-suppressible by Scer\GAL4^ap-md544/dx^ΔPRM.UAS

(Capilla et al., 2012)

dsh¹ has leg phenotype, non-suppressible by Scer\GAL4^ap-md544/dx^mRZF.UAS

(Capilla et al., 2012)

dsh¹ has phenotype, non-suppressible by Gli^dv5

(Venema et al., 2004)

dsh¹ has wing hair phenotype, non-suppressible by Rok^αTub84B.PW

(Winter et al., 2001)

dsh¹ has wing hair phenotype, non-suppressible by sqh^E20.E21

(Winter et al., 2001)

dsh¹ has phenotype, non-suppressible by fz^hs.sev

(Boutros et al., 1998)

Enhancer of

Statement

Reference

dsh¹/dsh¹ is an enhancer of wing margin bristle phenotype of meru¹

(Banerjee et al., 2017)

dsh¹/dsh[+] is an enhancer of adult mushroom body beta-lobe | adult stage phenotype of tap^Gal4

(Yuan et al., 2016)

dsh¹/dsh[+] is an enhancer of adult mushroom body alpha-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

dsh¹/dsh[+] is an enhancer of adult mushroom body beta-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

dsh¹ is an enhancer of wing hair phenotype of sha^VB13

(Ren et al., 2006)

dsh¹ is an enhancer of axon & dorsal cluster neuron phenotype of Scer\GAL4^ato.3.6, bsk^DN.UAS

(Srahna et al., 2006)

dsh¹/dsh[+] is an enhancer of axon & dorsal cluster neuron phenotype of Wnt5⁴⁰⁰

(Srahna et al., 2006)

dsh¹/dsh[+] is an enhancer of ommatidium phenotype of fz²⁰/fz¹⁹

(Strutt et al., 2006)

dsh¹/dsh[+] is an enhancer of ommatidium phenotype of dgo²⁶⁹

(Jenny et al., 2005)

dsh¹ is an enhancer of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

dsh¹ is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Jenny et al., 2003)

dsh¹ is an enhancer of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

dsh¹ is an enhancer of ommatidium phenotype of fz²⁰/fz¹⁹

(Strutt and Strutt, 2003)

dsh¹ is an enhancer of wing hair & 1st posterior cell phenotype of in^II53

(Lee and Adler, 2002)

NOT Enhancer of

Statement

Reference

dsh¹ is a non-enhancer of ommatidium | somatic clone - Minute background phenotype of Frl^Ex83

(Dollar et al., 2016)

dsh¹ is a non-enhancer of ommatidium | somatic clone - Minute background phenotype of Frl^ExK62

(Dollar et al., 2016)

dsh¹/dsh[+] is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

dsh¹/dsh[+] is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dsh¹/dsh[+] is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

dsh¹ is a non-enhancer of axon & dorsal cluster neuron phenotype of Rac1^N17.UAS, Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

dsh¹ is a non-enhancer of phenotype of Gli^dv5

(Venema et al., 2004)

Suppressor of

Statement

Reference

dsh¹/dsh[+] is a suppressor | partially of humeral bristle phenotype of Nab2^ex3

(Lee et al., 2020)

dsh¹ is a suppressor | partially of mushroom body medial lobe phenotype of Scer\GAL4^ey-OK107, Vang^UAS.mGFP6

(Gombos et al., 2015)

dsh¹ is a suppressor | partially of mushroom body medial lobe phenotype of Scer\GAL4^ey-OK107, Wnt5^UAS.cFa

(Gombos et al., 2015)

dsh¹/dsh[+] is a suppressor of ommatidium phenotype of bdg^GMREP

(Rawls et al., 2007)

dsh¹/dsh[+] is a suppressor of axon & dorsal cluster neuron & adult brain phenotype of Scer\GAL4^ato.3.6, btl^DN.UAS

(Srahna et al., 2006)

dsh¹/dsh[+] is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Jenny et al., 2005)

dsh¹ is a suppressor of wing hair | somatic clone | cell non-autonomous phenotype of fz²³

(Lee and Adler, 2002)

dsh¹/dsh[+] is a suppressor of wing hair | increased number phenotype of fz^I.hs

(Winter et al., 2001)

NOT Suppressor of

Statement

Reference

dsh¹ is a non-suppressor of ommatidium | somatic clone - Minute background phenotype of Frl^Ex83

(Dollar et al., 2016)

dsh¹ is a non-suppressor of ommatidium | somatic clone - Minute background phenotype of Frl^ExK62

(Dollar et al., 2016)

dsh¹/dsh[+] is a non-suppressor of mushroom body phenotype of DAAM^C.UASp, Scer\GAL4^ey-OK107

(Gombos et al., 2015)

dsh¹/dsh[+] is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

dsh¹/dsh[+] is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

dsh¹/dsh[+] is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, shg^{dCR3h.UAS.sgGFP}

(Mirkovic and Mlodzik, 2006)

dsh¹ is a non-suppressor of axon & dorsal cluster neuron phenotype of Rac1^N17.UAS, Scer\GAL4^ato.3.6

(Srahna et al., 2006)

dsh¹ is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

dsh¹ is a non-suppressor of phenotype of Gli^dv5

(Venema et al., 2004)

dsh¹ is a non-suppressor of wing hair | somatic clone | cell autonomous phenotype of fz²³

(Lee and Adler, 2002)

dsh¹ is a non-suppressor of wing hair | somatic clone | cell non-autonomous phenotype of fz²³

(Lee and Adler, 2002)

dsh¹ is a non-suppressor of wing margin bristle | ectopic phenotype of Scer\GAL4^71B, fz::fz2^{fz2CRD.UAS.Tag:MYC}

(Rulifson et al., 2000)

dsh¹ is a non-suppressor of wing phenotype of Scer\GAL4^71B, fz::fz2^{fz2CRD.UAS.Tag:MYC}

(Rulifson et al., 2000)

Other

Statement

Reference

Rho1^72O, dsh¹ has femur phenotype

(Mieszczanek et al., 2022)

dsh¹/dsh[+], kmr² has wing hair phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr² has interommatidial bristle phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr² has trichome phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr² has thoracic tergum phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr¹ has wing hair phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr¹ has interommatidial bristle phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr¹ has trichome phenotype

(Shami Shah et al., 2019)

dsh¹/dsh[+], kmr¹ has thoracic tergum phenotype

(Shami Shah et al., 2019)

Rac1^J11/Rac1[+], dsh¹ has mushroom body phenotype

(Gombos et al., 2015)

dsh¹, mud^f01205 has spindle | P-stage phenotype

(Ségalen et al., 2010)

dsh¹, mud⁴ has spindle | P-stage phenotype

(Ségalen et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Double-heterozygous flies of the genotype dsh[1]/+ together with either kmr¹/+ or kmr²/+ display misoriented hair patterns on the wing, thorax and eyes, while single heterozygotes exhibit phenotypes similar to wild-type controls.

(Shami Shah et al., 2019)

The severity of both the wing margin bristle and the thoracic macrochaetae defects observed in meru¹ or dsh¹ flies are also significantly worsened in the double mutants.

(Banerjee et al., 2017)

Presence of Frl^Ex83/+ or Frl^ExK62/+ does not significantly alter eye phenotypes seen in dsh¹/Y flies. Presence of dsh¹/Y (or dsh¹/+ females) does not significantly alter eye phenotypes in Frl^Ex83/Frl^Ex83 or Frl^ExK62/Frl^ExK62 clones. Presence of Frl^Ex83/+ or Frl^Ex88/+ does not enhance mushroom body axon growth defects seen in dsh¹/Y flies.

(Dollar et al., 2016)

dsh¹/+ significantly enhances frequency of mushroom body beta lobe axon overgrowth defects (midline crossing) in tap^Gal4/+ brains.

(Yuan et al., 2016)

One copy of dsh¹ enhances the axonal projection defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies in females. Very few, if any, defects are seen in dsh¹ DAAM^Ex1 double heterozygotes. DAAM^Ex1 enhances the axon projection phenotypes seen in dsh¹/Y males alone. Many of these double hemizygous males exhibit an early growth termination phenotype not seen in either mutant alone.

dsh¹ does not suppress the growth and guidance defects seen in the mushroom body axons of flies expressing DAAM^{C.Scer\UAS.P\T} under the control of Scer\GAL4^ey-OK107.

Hemizygous dsh¹ mutant males with one copy of Rac1^J11 exhibit an early growth termination phenotype in the mushroom body axons that is not observed in either dsh¹/Y or Rac1^J11/+ males alone.

Hemizygous dsh¹ partially suppresses the medial lobe fusion phenotype seen when Vang^{Scer\UAS.T:Avic\GFP-m6} is expressed in male flies under the control of Scer\GAL4^ey-OK107.

Hemizygous dsh¹ partially suppresses the medial lobe fusion phenotype seen when Wnt5^Scer\UAS.cFa is expressed in male flies under the control of Scer\GAL4^ey-OK107.

(Gombos et al., 2015)

Expression of Rab5^Scer\UAS.cEa under the control of Scer\GAL4^ap-md544 partially suppresses the dsh¹ ectopic leg joint phenotype, with partial suppression being seen in 80% of the legs examined.

Expression of either dx^Scer\UAS.cMa, dx^{ΔPRM.Scer\UAS} or dx^{mRZF.Scer\UAS} under the control of Scer\GAL4^ap-md544 has no effect on the ectopic leg joint phenotype of dsh¹ flies.

Expression of dx^{ΔNBS.Scer\UAS} under the control of Scer\GAL4^ap-md544 in a dsh¹ background partially inhibits normal joint formation (this phenotype seen in dx^{ΔNBS.Scer\UAS}, Scer\GAL4^ap-md544 single mutant) and partially suppresses the formation of ectopic leg joints seen in dsh¹ single mutants.

(Capilla et al., 2012)

The dsh¹ planar cell polarity (PCP) phenotype in the eye is strongly enhanced by the expression of CG15283^GD13108 under the control of Scer\GAL4^hs.2sev.

(Weber et al., 2012)

Mitotic spindle is aligned with the pins crescent is most dsh¹/dsh¹ pupal sensory mother cells in metaphase, but spindle fails to align in dsh¹;mud⁴ or dsh¹;mud^f01205 double mutants.

(Ségalen et al., 2010)

ed^1X5 dominantly enhances the phenotype of mis-rotation of ommatidia that is seen in dsh¹ animals.

(Fetting et al., 2009)

The multiple wing hair phenotype seen in dsh¹/Y flies is suppressed by tow⁷⁵⁴/+, but the defects in polarity of the hairs is not affected.

(Chung et al., 2007)

The ommatidial polarity defects caused by dsh¹ are enhanced by one copy of bdg^GMREP or bdg¹⁶⁴.

The ommatidial polarity defects seen in bdg^GMREP homozygotes are dominantly suppressed by dsh¹.

(Rawls et al., 2007)

Clones expressing fz^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^Act5C.PI in a dsh¹ background result in non-clonal cells pointing their trichomes away from the clone. This effect extends at most 3-4 cells from the clone boundary.

(Strutt and Strutt, 2007)

A dsh¹/+ background does not affect the Scer\GAL4^hs.2sev>shg^{dCR3h.Scer\UAS.T:Avic\GFP-rs} ommatidial phenotype.

(Mirkovic and Mlodzik, 2006)

Wnt5⁴⁰⁰/+, dsh¹/+ double mutants show a more severe dorsal cluster neuron axon phenotype than dsh¹/+ single mutants.

Expression of Rac1^N17.Scer\UAS, under the control of Scer\GAL4^ato.3.6, in a dsh¹ background results in a dorsal neuron cluster phenotype similar to when Rac1^N17.Scer\UAS is expressed in a wild-type background, which is opposite to that seen in dsh¹ mutants.

Expression of hep^Scer\UAS.cBa, under the control of Scer\GAL4^ato.3.6, in a dsh¹ background results in a large increase of dorsal cluster neuron axons crossing the optic chiasm, indicating a complete dominance of the hep gain of function phenotype.

Expression of one copy of bsk^DN.Scer\UAS, under the control of Scer\GAL4^ato.3.6, in dsh¹ mutant animals results in a synergistic reduction of extension of dorsal cluster neuron axons, with 60% showing no axons crossing the optic chiasm.

Expression of btl^DN.Scer\UAS under the control of Scer\GAL4^ato.3.6 in a dsh¹/+ background suppresses the reduction of dorsal cluster neuron axon extension phenotype seen in either single mutant, with the number of dorsal cluster neuron axons crossing the optic chiasm restored to almost wild-type levels.

(Srahna et al., 2006)

The ommatidial polarity defects of fz¹⁹/fz²⁰ mutants are enhanced in fz¹⁹/fz²⁰; dsh¹/+ double mutants.

(Strutt et al., 2006)

The planar cell polarity defects seen in the eyes of flies expressing dgo^Scer\UAS.cFa under the control of Scer\GAL4^hs.2sev are dominantly suppressed by dsh¹/+.

The weak planar cell polarity phenotype seen in the eyes of dgo²⁶⁹ homozygotes is enhanced by dsh¹/+.

The planar cell polarity phenotype seen in the eyes of dsh¹/Y flies is partially suppressed by pk¹/+.

(Jenny et al., 2005)

Removing one copy of Mbs antagonizes the multiple wing hair formation in dsh¹/Y mutants but has no effect on the planar polarity defects.

(Lee and Treisman, 2004)

Gli^dv5/Gli^dv5, dsh¹/+ animals exhibit an additive wing hair phenotype.

(Venema et al., 2004)

Moe^G0323/+ suppresses the frequency of wing cells with double hairs in dsh¹ flies to 1.2 +/- 0.2%.

(Speck et al., 2003)

The addition of dsh¹/+ strongly enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals.

(Strutt and Strutt, 2003)

Parp^GMR.PU shows no genetic interaction with dsh¹/+.

(Uchida et al., 2002)

The average number of cells having multiple wing hairs in a defined region of the wing (the ventral surface of the proximal-anterior region) is reduced by more than 7-fold in dsh¹ males that are also expressing rok^αTub84B.PW compared to dsh¹ single mutants. The hair misorientation phenotype is not suppressed. Suppression of ectopic F-actin-rich prehairs is seen in double mutant pupae, but the abnormal assembly of the prehair at the centre of the cell is not suppressed. Addition of rok² to dsh¹ mutants results in a 2.5-fold increase in the number of multiple wing hair cells compared to dsh¹ single mutants. The dsh¹ multiple hair phenotype but not the hair misorientation phenotype is suppressed by sqh^E20.E21.

(Winter et al., 2001)

The presence of Rac1^hs.sev significantly rescues the dsh¹ eye phenotype, increasing the percentage of correctly polarised ommatidia.

(Fanto et al., 2000)

The planar polarity defect in dsh¹ wings that are expressing fz^Scer\UAS.cAa under the control of Scer\GAL4^71B is indistinguishable from the dsh¹ single mutant phenotype.

(Rulifson et al., 2000)

The dsh¹ phenotype is partially rescued by HLHmβ^{Scer\UAS.cdCa} expressed under the control of Scer\GAL4^salm-459.2.

(Cooper and Bray, 1999)

Double mutants of Vang^Tbs42, Vang^A3 or Vang^A5 with fz²⁴, dsh¹ in^unspecified and mwh^unspecified all showed hair polarity pattern typical of the fz-in group. Multiple hair cell phenotypes of the cell autonomous dsh, in and mwh mutants are epistatic to Vang. Show no interaction with the dominant wing basal cell 1 swirl phenotype of Vang^Tbs42.

(Taylor et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dsh¹ is rescued by dsh^EGFP

(Capilla et al., 2012)

dsh¹ is rescued by dsh^ST5.EGFP

(Strutt et al., 2006)

dsh¹ is rescued by dsh^{CK2.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is rescued by dsh^{ST1.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is rescued by dsh^{ΔBasic.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is rescued by dsh^{CK4.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is rescued by dsh^{fl.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is rescued by dsh^{CK3.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is rescued by dsh^hs.PA

(Axelrod et al., 1998)

dsh¹ is rescued by dsh^hs.sev.B

(Boutros et al., 1998)

dsh¹ is rescued by dsh^ΔDIX.hs.sev

(Boutros et al., 1998)

Partially rescued by

dsh¹ is partially rescued by dsh^Tag:FLAG

(Steinhauer et al., 2019)

dsh¹ is partially rescued by dsh^mut6.EGFP

(Capilla et al., 2012)

dsh¹ is partially rescued by dsh^ST8.EGFP

(Strutt et al., 2006)

dsh¹ is partially rescued by dsh^ΔPDZ.hs.sev

(Boutros et al., 1998)

dsh¹ is partially rescued by dsh^w

(Theisen et al., 1994)

Not rescued by

dsh¹ is not rescued by dsh^1.EGFP

(Capilla et al., 2012)

dsh¹ is not rescued by dsh^Y473F.EGFP

(Yanfeng et al., 2011)

dsh¹ is not rescued by dsh^{ST45.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is not rescued by dsh^{ΔDEPD-2.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is not rescued by dsh^{ΔPDZ.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is not rescued by dsh^{ST124.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is not rescued by dsh^{ST4.hs.Tag:MYC}

(Penton et al., 2002)

dsh¹ is not rescued by dsh^ΔDEP+.UAS/Scer\GAL4^hs.PB

(Axelrod et al., 1998)

dsh¹ is not rescued by dsh^ΔbPDZ.UAS/Scer\GAL4^hs.PB

(Axelrod et al., 1998)

dsh¹ is not rescued by dsh^DEP+.hs

(Axelrod et al., 1998)

dsh¹ is not rescued by dsh^ΔC.hs.sev

(Boutros et al., 1998)

dsh¹ is not rescued by dsh^1.hs.sev

(Boutros et al., 1998)

Comments

dsh^{T:Avic\GFP-EGFP} rescues the ectopic leg joint phenotype of dsh¹ animals.

dsh^{mut6.T:Avic\GFP-EGFP} partially rescues the ectopic leg joint phenotype of dsh¹ animals.

dsh^{1.T:Avic\GFP-EGFP} fails to rescue the ectopic leg joint phenotype of dsh¹ animals.

(Capilla et al., 2012)

Expression of dsh^{Y473F.T:Avic\GFP-EGFP} is unable to rescue the PCP defects seen in dsh¹ mutants.

(Yanfeng et al., 2011)

Expression of dsh^{ST8.T:Avic\GFP-EGFP} partially rescues the polarity defects of dsh¹ mutants; most of the wing hairs show correct polarity but some regions are left with polarity defects.

(Strutt et al., 2006)

Suppresses the ommatidial polarity defects seen in dsh^hs.sev.B.

(Paricio et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5298

w¹ dsh¹

Kyoto

108157

w¹ dsh¹

Notes on Origin

Discoverer

Fahmy, 1956.

Fahmy.

(Perrimon and Mahowald, 1987)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dsh

(Fahmy and Fahmy, 1959)

dsh1

(Vandewalle et al., 2013, Doyle et al., 2008)

dsh¹

(Dominicci-Cotto et al., 2024, Song et al., 2023, Strutt et al., 2023, Corgiat et al., 2022, Darnat et al., 2022, Mieszczanek et al., 2022, Arguello et al., 2021, Marquilly et al., 2021, Cho et al., 2020, Han et al., 2020, Lee et al., 2020, Domingos et al., 2019, Shami Shah et al., 2019, Steinhauer et al., 2019, Strutt et al., 2019, Thuveson et al., 2019, Katanaev et al., 2018, Ressurreição et al., 2018, Banerjee et al., 2017, Kaur et al., 2017, Warrington et al., 2017, Weber and Mlodzik, 2017, Bergstralh et al., 2016, Dollar et al., 2016, Yuan et al., 2016, Gombos et al., 2015, Strutt et al., 2013, Vandewalle et al., 2013, Warrington et al., 2013, Capilla et al., 2012, Peng et al., 2012, Weber et al., 2012, Goossens et al., 2011, Matsubara et al., 2011, Mirkovic et al., 2011, Shimizu et al., 2011, Yanfeng et al., 2011, Djiane and Mlodzik, 2010, Kaplan and Tolwinski, 2010, Pataki et al., 2010, Popodi et al., 2010-, Ségalen et al., 2010, Chung et al., 2009, Fetting et al., 2009, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Doyle et al., 2008, Bastock and Strutt, 2007, Christensen and Cook, 2007.5.8, Christensen and Cook, 2007.5.8, Chung et al., 2007, Rawls et al., 2007, Strutt and Strutt, 2007, Bartscherer et al., 2006, Mirkovic and Mlodzik, 2006, Ren et al., 2006, Srahna et al., 2006, Strutt et al., 2006, Jenny et al., 2005)

dsh^K417M

(Yanfeng et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (119)

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