FB2024_03 , released June 25, 2024
Allele: Dmel\fz::fz2fz2CRD.UAS.Tag:MYC
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General Information
Symbol
Dmel\fz::fz2fz2CRD.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0122976
Feature type
allele
Associated gene
fz::fz2
Associated Insertion(s)
Carried in Construct
P{UAS-fz2CRD.fz}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Rulifson et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-fz2CRD.fz}
Cytology
Description

UAS regulatory sequences drive expression of a fz::fz2 chimera, which consists of fz sequences with the fz2 cysteine-rich domain (CRD), tagged with Tag:MYC after the fz2 CRD.

(Rulifson et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
fz::fz2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of one copy of fz::fz2fz2CRD.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL471B results in extra wing margin bristle and wing polarity phenotypes. Both phenotypes are increased by increasing the fz::fz2fz2CRD.Scer\UAS.T:Hsap\MYC copy number.

      (Rulifson et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Scer\GAL471B, fz::fz2fz2CRD.UAS.Tag:MYC has visible phenotype, non-suppressible by dsh1

      (Rulifson et al., 2000)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Scer\GAL471B, fz::fz2fz2CRD.UAS.Tag:MYC has wing margin bristle | ectopic phenotype, non-suppressible by dsh1

      (Rulifson et al., 2000)

      Scer\GAL471B, fz::fz2fz2CRD.UAS.Tag:MYC has wing phenotype, non-suppressible by dsh1

      (Rulifson et al., 2000)
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Df(3L)fz-D21 Df(3L)fz2 embryos derived from fz23/Df(3L)fz-D21 Df(3L)fz2 females show a "denticle lawn" cuticle phenotype which is suppressed by expression of fz::fz2fz2CRD.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4da.G32. The extra wing margin bristle phenotype in dsh1 wings that are expressing fz::fz2fz2CRD.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL471B is comparable to that of dsh+ flies that are expressing fz::fz2fz2CRD.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL471B.

      (Rulifson et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fz::fz2fz2CRD.Scer\UAS.T:Hsap\MYC
      fz::fz2fz2CRD.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)