FlyBase Allele Report: Dmel\dsh[ΔDEP+.UAS]

General Information

Symbol

Dmel\dsh^ΔDEP+.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0093072

Feature type

allele

Associated gene

Dmel\dsh

Associated Insertion(s)

Carried in Construct

P{UAS-dsh.ΔDEP+}

Also Known As

UAS-dshΔDEP

Key Links

Transgenic product class

inframe_deletion

(Axelrod et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Axelrod et al., 1998)

Mutagen

in vitro construct

(Axelrod et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-dsh.ΔDEP+}

Cytology

Description

dsh amino acids 1 to 394 are expressed under the control of UASt regulatory sequences.

(Axelrod et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsh

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Sato et al., 2006)

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR95A09

(Han et al., 2020)

abnormal neuroanatomy | P-stage, with Scer\GAL4^bsh.M.PT

(Han et al., 2020)

abnormal neuroanatomy | P-stage, with Scer\GAL4^GMR69B02

(Han et al., 2020)

abnormal neuroanatomy | P-stage, with Scer\GAL4^sens.F2

(Han et al., 2020)

abnormal neuroanatomy | P-stage, with Scer\GAL4^sev.PM181

(Han et al., 2020)

abnormal planar polarity, with Scer\GAL4^hs.PB

(Axelrod et al., 1998)

abnormal planar polarity, with Scer\GAL4^ptc-559.1

(Axelrod, 2001)

Phenotype Manifest In

eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Sato et al., 2006)

lamina, with Scer\GAL4^GMR.PF

(Sato et al., 2006)

medulla | P-stage, with Scer\GAL4^bsh.M.PT

(Han et al., 2020)

medulla | P-stage, with Scer\GAL4^GMR69B02

(Han et al., 2020)

medulla | P-stage, with Scer\GAL4^sens.F2

(Han et al., 2020)

medulla | P-stage, with Scer\GAL4^sev.PM181

(Han et al., 2020)

medullary intrinsic neuron Mi1 | adult stage, with Scer\GAL4^GMR95A09

(Han et al., 2020)

medullary intrinsic neuron Mi1 | P-stage | somatic clone, with Scer\GAL4^bsh.M.PT

(Han et al., 2020)

neuron, with Scer\GAL4^GMR.PF

(Sato et al., 2006)

photoreceptor cell R8 | P-stage | somatic clone, with Scer\GAL4^bsh.M.PT

(Han et al., 2020)

Detailed Description

Statement

Reference

Expressing dsh^ΔDEP+.UAS under the control of Scer\GAL4^HCH.Hand fails to induce defects in heart morphology or ostia formation in embryos.

(Chen et al., 2016)

Expression of dsh^{ΔDEP+.Scer\UAS} under the control of Scer\GAL4^fkh.PZ has no effect on salivary gland guidance in the embryo.

(Harris and Beckendorf, 2007)

Expression of the dominant-negative dsh^{ΔDEP+.Scer\UAS} in the retina behind the furrow using Scer\GAL4^GMR.PF results in a strong ventral-to-dorsal R axon misrouting phenotype.

(Sato et al., 2006)

Expression of dsh^{ΔDEP+.Scer\UAS} under the control of Scer\GAL4^ptc-559.1 results in a polarity defect.

(Axelrod, 2001)

Expression of dsh^{ΔDEP+.Scer\UAS} at 24 hours after pupariation under the control of Scer\GAL4^hs.PB results in a tissue polarity phenotype in the wing.

(Axelrod et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^da.G32/dsh^ΔDEP+.UAS is a suppressor of denticle | ectopic phenotype of wg^l-17

(Morel and Arias, 2004)

Scer\GAL4^da.G32/dsh^ΔDEP+.UAS is a suppressor of embryonic leading edge cell primordium phenotype of wg^l-17

(Morel and Arias, 2004)

Scer\GAL4^da.G32/dsh^ΔDEP+.UAS is a suppressor of embryonic/first instar larval cuticle phenotype of wg^l-17

(Morel and Arias, 2004)

dsh^ΔDEP+.UAS/Scer\GAL4^69B is a suppressor of amnioserosa phenotype of hep¹

(Kaltschmidt et al., 2002)

dsh^ΔDEP+.UAS/Scer\GAL4^69B is a suppressor of embryonic dorsal epidermis phenotype of hep¹

(Kaltschmidt et al., 2002)

dsh^ΔDEP+.UAS/Scer\GAL4^69B is a suppressor of embryonic leading edge cell & actin filament phenotype of hep¹

(Kaltschmidt et al., 2002)

dsh^ΔDEP+.UAS/Scer\GAL4^69B is a suppressor of embryonic/first instar larval cuticle | dorsal phenotype of hep¹

(Kaltschmidt et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

dsh^{ΔDEP+.Scer\UAS}; Scer\GAL4^da.G32 partially suppresses the transformation of naked ventral cuticle into denticles and reduction in cuticle length seen in cuticles from wg^l-17 homozygous embryos, and an completely suppress the dorsal hole in these cuticles. dsh^{ΔDEP+.Scer\UAS}; Scer\GAL4^da.G32 suppresses, the loss of dorsal ventral polarity in the leading edge cells of stage 13 wg^l-17 homozygous embryos but fails to rescue elongation of these cells. However, initiation of the anterior zipper during dorsal closure is rescued.

(Morel and Arias, 2004)

The dorsal hole phenotype, loss of leading edge actin cable, and loss of adhesion between the amnioserosa and dorsal epidermis of hep¹ mutant embryos are all partially suppressed by Scer\GAL4^69B with dsh^{ΔDEP+.Scer\UAS}.

(Kaltschmidt et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

dsh^ΔDEP+.UAS/Scer\GAL4^hs.PB fails to rescue dsh¹

(Axelrod et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dsh^{ΔDEP+.Scer\UAS}

dsh^ΔDEP+.UAS

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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