FlyBase Allele Report: Dmel\Rok[αTub84B.PW]

General Information

Symbol

Dmel\Rok^αTub84B.PW

Species

D. melanogaster

Name

α-Tubulin at 84B promoter construct of Winter

FlyBase ID

FBal0122920

Feature type

allele

Associated gene

Dmel\Rok

Associated Insertion(s)

Carried in Construct

P{αTub84B-Rok.W}

Key Links

Transgenic product class

cDNA

(Winter et al., 2001)

wild_type

(Winter et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Winter et al., 2001)

wild_type

(Winter et al., 2001)

Mutagen

in vitro construct

(Winter et al., 2001)

Progenitor genotype

Carried in construct

P{αTub84B-Rok.W}

Cytology

Description

A αTub84B promoter drives expression of a full length Rok cDNA. An SV40 polyA signal sequence is also present.

(Winter et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

αTub84B

Encoded product / tool

Rok

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Winter et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of rok^αTub84B.PW in a wild-type background does not give rise to any obvious phenotypes.

(Winter et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Rok^αTub84B.PW is a suppressor | partially of visible phenotype of Scer\GAL4^hs.PB, tow^UAS.cCa

(Chung et al., 2007)

Rok^αTub84B.PW is a suppressor of visible | recessive phenotype of dsh¹

(Winter et al., 2001)

NOT Suppressor of

Statement

Reference

Rok^αTub84B.PW is a non-suppressor of abnormal planar polarity phenotype of dsh¹

(Winter et al., 2001)

Phenotype Manifest In

Suppressor of

Statement

Reference

Rok^αTub84B.PW is a suppressor | partially of wing hair | increased number phenotype of Scer\GAL4^hs.PB, tow^UAS.cCa

(Chung et al., 2007)

Rok^αTub84B.PW is a suppressor of wing hair | increased number phenotype of dsh¹

(Winter et al., 2001)

NOT Suppressor of

Statement

Reference

Rok^αTub84B.PW is a non-suppressor of wing hair phenotype of dsh¹

(Winter et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The multiple wing hair phenotype caused by expression of tow^Scer\UAS.cCa under the control of Scer\GAL4^hs.PB using heat shock at 24 hours after puparium formation is partially suppressed by co-expression of rok^αTub84B.PW.

(Chung et al., 2007)

The average number of cells having multiple wing hairs in a defined region of the wing (the ventral surface of the proximal-anterior region) is reduced by more than 7-fold in dsh¹ males that are also expressing rok^αTub84B.PW compared to dsh¹ single mutants. The hair misorientation phenotype is not suppressed. Suppression of ectopic F-actin-rich prehairs is seen in double mutant pupae, but the abnormal assembly of the prehair at the centre of the cell is not suppressed.

(Winter et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Rok^αTub84B.PW rescues Rok¹

(Winter et al., 2001)

Rok^αTub84B.PW rescues Rok²

(Winter et al., 2001)

Fails to rescue

Rok^αTub84B.PW fails to rescue Df(1)YO17