FB2024_03 , released June 25, 2024
Allele: Dmel\towUAS.cCa
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General Information
Symbol
Dmel\towUAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Chung
FlyBase ID
FBal0215225
Feature type
allele
Associated gene
Dmel\tow
Associated Insertion(s)
Carried in Construct
P{UAS-tow.C}
Key Links
Transgenic product class
cDNA
(Chung et al., 2007)
wild_type
(Chung et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Chung et al., 2007)
wild_type
(Chung et al., 2007)
Mutagen
in vitro construct
(Chung et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-tow.C}
Cytology
Description

UASt regulatory sequences drive expression of the full-length tow cDNA GH12583.

(Chung et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
tow
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of towScer\UAS.cCa under the control of Scer\GAL4ap-md544 results in disorganisation of the microchaetae and stunted macrochaetae on the thorax and defects in the scutellum. A multiple wing hair phenotype is seen in the wing and the wing blade is uneven and wavy.

      Expression of towScer\UAS.cCa under the control of Scer\GAL4Bx-MS1096 results in a multiple wing hair phenotype in the adult wing. A multiple pre-hair phenotype is seen in pupae expressing towScer\UAS.cCa under the control of Scer\GAL4Bx-MS1096, with most wing cells forming more than one F-actin bundle.

      Flies expressing towScer\UAS.cCa under the control of Scer\GAL4Bx-MS1096 have extra bristles in the anterior wing margin and in the wing blade near the most distal region.

      Expression of towScer\UAS.cCa under the control of Scer\GAL4hs.2sev has no effect on ommatidial polarity in the eye.

      Expression of towScer\UAS.cCa under the control of Scer\GAL4hs.PB using heat shock at 24 hours after puparium formation causes the formation of multiple wing hairs throughout the wing blade. These wing hairs have largely normal polarity.

      (Chung et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4hs.PB, towUAS.cCa has visible phenotype, enhanceable by RokCAT-KG.UAS, Scer\GAL4hs.PB

      (Chung et al., 2007)

      Scer\GAL4hs.PB, towUAS.cCa has visible phenotype, enhanceable by zipIIX62/zip[+]

      (Chung et al., 2007)

      Scer\GAL4hs.PB, towUAS.cCa has visible phenotype, enhanceable by Rho172O/Rho1[+]

      (Chung et al., 2007)

      Scer\GAL4hs.PB, towUAS.cCa has visible phenotype, enhanceable by rok[+]/Rok2

      (Chung et al., 2007)

      Scer\GAL4hs.PB, towUAS.cCa has visible phenotype, enhanceable by sqhAX3/sqh[+]

      (Chung et al., 2007)

      Scer\GAL4hs.PB, towUAS.cCa has visible phenotype, enhanceable by zip[+]/zip1

      (Chung et al., 2007)
      Suppressed by
      Enhancer of
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Enhancer of
      Statement
      Reference

      towUAS.cCa/Scer\GAL4hs.2sev is an enhancer of ommatidium phenotype of Scer\GAL4hs.2sev, fzUAS.cAa

      (Chung et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The planar polarity defects seen in the eyes of animals expressing fzScer\UAS.cAa under the control of Scer\GAL4hs.2sev are enhanced by co-expression of towScer\UAS.cCa (only 26.4% of ommatidia are correctly rotated).

      The multiple wing hair phenotype caused by expression of towScer\UAS.cCa under the control of Scer\GAL4hs.PB using heat shock at 24 hours after puparium formation is partially suppressed by co-expression of one of Rho1Scer\UAS.cMa, rokCAT.Scer\UAS or rokαTub84B.PW.

      The multiple wing hair phenotype caused by expression of towScer\UAS.cCa under the control of Scer\GAL4hs.PB using heat shock at 24 hours after puparium formation is partially suppressed by one copy of ck13 or ck07130.

      The multiple wing hair phenotype caused by expression of towScer\UAS.cCa under the control of Scer\GAL4hs.PB using heat shock at 24 hours after puparium formation is enhanced by co-expression of rokCAT-KG.Scer\UAS.

      The multiple wing hair phenotype caused by expression of towScer\UAS.cCa under the control of Scer\GAL4hs.PB using heat shock at 24 hours after puparium formation is enhanced if the flies are also carrying one copy of Rho172O, rok2, sqhAX3, zip1 or zipIIX62.

      (Chung et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      towScer\UAS.cCa
      towUAS.cCa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Chung
      Secondary FlyBase IDs
        References (1)