FlyBase Allele Report: Dmel\CG15283[GD13108]

General Information

Symbol

Dmel\CG15283^GD13108

Species

D. melanogaster

Name

FlyBase ID

FBal0201262

Feature type

allele

Associated gene

Dmel\CG15283

Associated Insertion(s)

Carried in Construct

P{GD13108}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD13108}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD13108

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity, with Scer\GAL4^dpp.blk1

(Weber et al., 2012)

abnormal planar polarity, with Scer\GAL4^en-e16E

(Weber et al., 2012)

abnormal planar polarity, with Scer\GAL4^hs.2sev

(Weber et al., 2012)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

ommatidium, with Scer\GAL4^hs.2sev

(Weber et al., 2012)

wing hair, with Scer\GAL4^dpp.blk1

(Weber et al., 2012)

wing hair, with Scer\GAL4^en-e16E

(Weber et al., 2012)

Detailed Description

Statement

Reference

Expression of CG15283^GD13108 using Scer\GAL4^hs.2sev results in planar cell polarity (PCP)-abnormalities in ommatidia.

Scer\GAL4^en-e16E>CG15283^GD13108 induces wing hair abnormalities.

Expression of CG15283^GD13108 under the control of Scer\GAL4^en-e16E results in wing hair orientation defects.

Expression of CG15283^GD13108 under the control of Scer\GAL4^dpp.blk1 results in wing hair orientation defects.

Flies expressing CG15283^GD13108 under the control of Scer\GAL4^ap-md544 display normal ommatidia and wing patterning.

(Weber et al., 2012)

Adults expressing CG15283^GD13108 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

13108

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

CG15283^GD13108, Scer\GAL4^en-e16E has abnormal planar polarity phenotype, enhanceable by dgo[+]/dgo³⁸⁰

(Weber et al., 2012)

Enhancer of

Statement

Reference

CG15283^GD13108, Scer\GAL4^hs.2sev is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

CG15283^GD13108/Scer\GAL4^hs.2sev is an enhancer of abnormal planar polarity phenotype of dsh¹

(Weber et al., 2012)

NOT Enhancer of

Statement

Reference

CG15283^GD13108, Scer\GAL4^hs.2sev is a non-enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Weber et al., 2012)

Suppressor of

Statement

Reference

CG15283^GD13108/Scer\GAL4^hs.2sev is a suppressor of abnormal planar polarity phenotype of dsh^hs.sev.B

(Weber et al., 2012)

NOT Suppressor of

Statement

Reference

CG15283^GD13108, Scer\GAL4^hs.2sev is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Weber et al., 2012)

Other

Statement

Reference

CG15283^GD13108, Scer\GAL4^en-e16E, pk[+]/pk^pk-sple-13 has abnormal planar polarity phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, dgo[+]/dgo²⁶⁹ has abnormal planar polarity phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+] has abnormal planar polarity phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, dgo[+]/dgo³⁸⁰, pk[+]/pk^pk-sple-13 has abnormal planar polarity phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+], dgo[+]/dgo²⁶⁹ has abnormal planar polarity phenotype

(Weber et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

CG15283^GD13108, Scer\GAL4^en-e16E has wing hair phenotype, enhanceable by dgo[+]/dgo³⁸⁰

(Weber et al., 2012)

Enhancer of

Statement

Reference

CG15283^GD13108, Scer\GAL4^hs.2sev is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

CG15283^GD13108/Scer\GAL4^hs.2sev is an enhancer of ommatidium phenotype of dsh¹

(Weber et al., 2012)

NOT Enhancer of

Statement

Reference

CG15283^GD13108, Scer\GAL4^hs.2sev is a non-enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Weber et al., 2012)

Suppressor of

Statement

Reference

CG15283^GD13108/Scer\GAL4^hs.2sev is a suppressor of ommatidium phenotype of dsh^hs.sev.B

(Weber et al., 2012)

NOT Suppressor of

Statement

Reference

CG15283^GD13108, Scer\GAL4^hs.2sev is a non-suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, pk^sple.UAS

(Weber et al., 2012)

Other

Statement

Reference

CG15283^GD13108, Scer\GAL4^en-e16E, pk[+]/pk^pk-sple-13 has wing hair phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, dgo[+]/dgo²⁶⁹ has wing hair phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+] has wing hair phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, dgo[+]/dgo³⁸⁰, pk[+]/pk^pk-sple-13 has wing hair phenotype

(Weber et al., 2012)

CG15283^GD13108, Scer\GAL4^en-e16E, Vang^stbm-6/Vang[+], dgo[+]/dgo²⁶⁹ has wing hair phenotype

(Weber et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Flies expressing CG15283^GD13108 under the control of Scer\GAL4^en-e16E in a pk^pk-sple-13/+ genetic background display wild-type wing hair polarity.

dgo³⁸⁰/+ causes wing hair whirls in 89% of flies expressing CG15283^GD13108 under the control of Scer\GAL4^en-e16E. The enhancement of the CG15283^GD13108 planar cell polarity (PCP)-phenotype by dgo³⁸⁰ is particularly robust.

The dsh^hs.sev.B gain-of-function planar cell polarity (PCP)-phenotype is markedly suppressed by the expression of CG15283^GD13108 via Scer\GAL4^hs.2sev.

The dsh¹ planar cell polarity (PCP) phenotype in the eye is strongly enhanced by the expression of CG15283^GD13108 under the control of Scer\GAL4^hs.2sev.

(Weber et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v28548

w¹¹¹⁸; P{GD13108}v28548

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

13108

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CG15283^GD13108

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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