FB2024_03 , released June 25, 2024
Allele: Dmel\Vha5516
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General Information
Symbol
Dmel\Vha5516
Species
D. melanogaster
Name
FlyBase ID
FBal0010430
Feature type
allele
Associated gene
Dmel\Vha55
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)87Ca16, l(3)87CaE2
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kennison and Tamkun, 1988)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      brm2 shows little if any interaction in double heterozygous combination with Vha5516; less than 3% of flies have held-out wings.

      (Vazquez et al., 1999)

      Mutation does not affect the level of w expression in ph-plac+3 flies.

      (Fauvarque et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Vha55[+]/Vha5516 is an enhancer of visible | heat sensitive phenotype of Ivir\M2UAS.cAa, Scer\GAL4GMR.PU

      (Adamson et al., 2011)
      Suppressor of
      Statement
      Reference

      Vha55[+]/Vha5516 is a suppressor of visible | adult stage phenotype of MitfUAS.cZa, Scer\GAL4dpp.blk1

      (Zhang et al., 2015)
      NOT Suppressor of
      Statement
      Reference

      maskUAS.cZa, Vha55[+], Vha5516, Scer\GAL4GMR.PU is a non-suppressor of visible | adult stage phenotype of Hsap\MAPTUAS.GFP, Scer\GAL4GMR.PU

      (Zhu et al., 2017)

      maskUAS.cZa, Vha55[+], Vha5516, Scer\GAL4GMR.PU is a non-suppressor of visible | adult stage phenotype of Hsap\FUSR518K.UAS.Tag:HA, Scer\GAL4GMR.PU

      (Zhu et al., 2017)

      Vha5516 is a non-suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

      (Maixner et al., 1998)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Vha55[+]/Vha5516 is an enhancer of eye | heat sensitive phenotype of Ivir\M2UAS.cAa, Scer\GAL4GMR.PU

      (Adamson et al., 2011)
      Suppressor of
      Statement
      Reference

      Vha55[+]/Vha5516 is a suppressor of wing | adult stage phenotype of MitfUAS.cZa, Scer\GAL4dpp.blk1

      (Zhang et al., 2015)

      Vha5516 is a suppressor of phenotype of Pc4

      (Kennison and Tamkun, 1988)
      NOT Suppressor of
      Statement
      Reference

      maskUAS.cZa, Vha55[+], Vha5516, Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of Hsap\MAPTUAS.GFP, Scer\GAL4GMR.PU

      (Zhu et al., 2017)

      maskUAS.cZa, Vha55[+], Vha5516, Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of Hsap\FUSR518K.UAS.Tag:HA, Scer\GAL4GMR.PU

      (Zhu et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small underdeveloped wing characteristic for adult flies expressing MitfScer\UAS.cZa under the control of Scer\GAL4dpp.blk1 is significantly suppressed by combination with a single copy of Vha5516.

      (Zhang et al., 2015)

      The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is not suppressed by Vha5516.

      (Maixner et al., 1998)

      Suppresses the extra sex comb phenotype of Pc4, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc4/+ extra sex combs phenotype.

      (Kennison and Tamkun, 1988)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (12)