FB2024_03 , released June 25, 2024
Allele: Dmel\mus301660
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General Information
Symbol
Dmel\mus301660
Species
D. melanogaster
Name
FlyBase ID
FBal0016038
Feature type
allele
Associated gene
Dmel\mus301
Associated Insertion(s)
Carried in Construct
Also Known As
spn-C660
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(McCaffrey et al., 2006)

antimorphic allele - genetic evidence

(Gonzalez-Reyes et al., 1997)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: M665K.

(McCaffrey et al., 2006)

Nucleotide substitution: T2185A.

(McCaffrey et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,140,021..8,140,021 [+]
Nucleotide change:

T8140021A

Reported nucleotide change:

T2185A

Amino acid change:

M665K | mus301-PA

Reported amino acid change:

M665K

(McCaffrey et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      100% of mus301660/Df(3L)66C-G28 egg chambers have a mutant karyosome, 4% have misplaced oocytes and 4% have small oocytes. 30% of eggs laid by mus301660/Df(3L)66C-G28 females are ventralised.

      98% of mus301660/mus301D1 egg chambers have a mutant karyosome. 45% of eggs laid by mus301660/mus301D1 females are ventralised.

      mus301660/Df(3L)66C-G28 females show 41% X chromosome nondisjunction. mus301660/Df(3L)ZP3 females show 42% X chromosome nondisjunction.

      mus301660/Df(3L)66C-G28 and mus301094/mus301660 larvae are sensitive to MMS compared to controls.

      (McCaffrey et al., 2006)

      Egg chambers of females exhibit a partially penetrant disruption in the positioning of the oocyte which can be located anywhere in the egg chamber.

      (Gonzalez-Reyes et al., 1997)

      In approximately 29% of mutant egg chambers, the oocyte fails to move to the posterior and lies either at the anterior of the germline cyst or in the middle, with nurse cells on both sides. Follicle cells migrate to the middle of the bipolar egg chamber, to form a belt around the oocyte.

      (Gonzalez-Reyes and St. Johnston, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Df(3L)66C-G28/mus301660 has karyosome phenotype, suppressible by Df(2L)pr65/lokp6

      (McCaffrey et al., 2006)
      NOT suppressed by
      Statement
      Reference

      Df(3L)66C-G28/mus301660 has karyosome phenotype, non-suppressible by grpfsA4

      (McCaffrey et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (6)