FlyBase Allele Report: Dmel\Ras85D[V12]

General Information

Symbol

Dmel\Ras85D^V12

Species

D. melanogaster

Name

FlyBase ID

FBal0030100

Feature type

allele

Associated gene

Dmel\Ras85D

Associated Insertion(s)

Carried in Construct

P{Ras85D^V12.hs}

Also Known As

Ras1^Val12, Ras1^V12

Key Links

Transgenic product class

Mutagen

Nature of the Allele

Transgenic product class

Mutagen

Progenitor genotype

Carried in construct

P{Ras85D^V12.hs}

Cytology

Description

Allele components

Component

Use(s)

Encoded product / tool

Ras85D

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Lai et al., 1996, Kauffmann et al., 1995)

visible | dominant

(Sturtevant et al., 1993)

Phenotype Manifest In

eye

(Lai et al., 1996)

photoreceptor cell R7

(Kauffmann et al., 1995, Kramer et al., 1995)

photoreceptor neuron

(Biggs et al., 1994)

Detailed Description

Statement

Reference

Modulation of voltage gated K⁺ currents induced by the neuropeptide pituitary adenylyl cyclase-activating polypeptide (PACAP38) is eliminated. The mutation fails to block or mimic PACAP38 (neuropeptide pituitary adenylyl cyclase-activating polypeptide) induced enhancement of K⁺ currents.

(Guo et al., 1997)

Extra R7 phenotype is suppressed by mutations in lilli.

(Dickson et al., 1996)

Dominantly enhances penetrance of extra crossveins in chic^gdh-5/Egfr^E1 heterozygotes.

(Doberstein et al., 1995)

Severe roughening of the eye external surface, section through the eye reveals multi R7 cells per ommatidium. Injection of a Ras CAAX peptidomimetic, FTI-244, significantly suppresses the mutant eye phenotype. Injection of a related compound, FTI-242, does not suppress the eye phenotype, but injection of FTI-254 does.

(Kauffmann et al., 1995)

Extra R7 cells formed in ommatidia.

(Kramer et al., 1995)

Rough eye phenotype.

(Biggs et al., 1994)

Rough eye. Heterozygous rho^Wk, rho^Mod and rho^Stg enhance the heterozygous phenotype.

(Sturtevant et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Ras85D^V12 has eye phenotype, enhanceable by ed^1X5

(Hsu et al., 1998)

Ras85D^V12 has eye phenotype, enhanceable by ttk⁰⁰²¹⁹

(Lai et al., 1996)

Ras85D^V12 has eye phenotype, enhanceable by ttk^rM730

(Lai et al., 1996)

NOT Enhanced by

Statement

Reference

Ras85D^V12 has eye phenotype, non-enhanceable by dos^2.42

(Herbst et al., 1996)

Ras85D^V12 has eye phenotype, non-enhanceable by dos^1.46

(Herbst et al., 1996)

Ras85D^V12 has eye phenotype, non-enhanceable by dos^unspecified

(Herbst et al., 1996)

NOT suppressed by

Statement

Reference

Ras85D^V12 has eye phenotype, non-suppressible by dos^2.42

(Herbst et al., 1996)

Ras85D^V12 has eye phenotype, non-suppressible by dos^1.46

(Herbst et al., 1996)

Ras85D^V12 has eye phenotype, non-suppressible by dos^unspecified

(Herbst et al., 1996)

Other

Statement

Reference

Ras85D^V12, lilli^3E8 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

ttk⁰⁰²¹⁹ and ttk^rM730 mildly enhance the mutant eye phenotype.

(Lai et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

See Simon, Cell 67:701 .

(Dickson et al., 1992)

Constitutively active protein.

(Doberstein et al., 1995)

Constitutively active allele.

(Kramer et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

RAS1^V12

(Herbst et al., 1996)

Ras1^-val12

(Venkatesh, 1993)

Ras1^V12

(Hsu et al., 1998, Karim and Rubin, 1998, Karim and Rubin, 1997, Dickson et al., 1996, Raabe et al., 1996, Dickson, 1995, Chang et al., 1994)

Ras1^Val12

(Lai et al., 1996, Sturtevant et al., 1993)

Ras1^val12

(Doberstein et al., 1995, Kauffmann et al., 1995, Biggs et al., 1994)

Ras85D^V12

Ras^Val12

(Guo et al., 1997)

Ras[V12]

(Lavery and Stern, 2006)

dRas^Val12

(Vidal and Cagan, 2006)

ras^Val12

(Vidal and Cagan, 2006)

Name Synonyms

Secondary FlyBase IDs

References (24)

Report Sections

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