FB2024_03 , released June 25, 2024
Allele: Dmel\ttk00219
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General Information
Symbol
Dmel\ttk00219
Species
D. melanogaster
Name
FlyBase ID
FBal0044412
Feature type
allele
Associated gene
Dmel\ttk
Associated Insertion(s)
P{PZ}ttk00219
Carried in Construct
Also Known As
ttk0219
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Lai et al., 1996)
Progenitor genotype
Associated Insertion(s)
P{PZ}ttk00219
Cytology
Description

P{PZ} insertion within enhancer elements of ttk.

(Lai et al., 1996)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mitotic clones in the adult eye exhibit aberrant ommatidia, contain extra R7 cells and occasionally lack outer photoreceptor cells.

      (Lai et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      ttk[+]/ttk00219 is an enhancer of wing margin bristle | ectopic phenotype of acHw-49c

      (Badenhorst et al., 2002)

      ttk[+]/ttk00219 is an enhancer of wing margin bristle | ectopic phenotype of acHw-1

      (Badenhorst et al., 2002)

      ttk[+]/ttk00219 is an enhancer of phenotype of aopyan-2

      (Lai et al., 1996)

      ttk[+]/ttk00219 is an enhancer of phenotype of aopA141

      (Lai et al., 1996)

      ttk00219 is an enhancer of eye phenotype of Ras85DV12

      (Lai et al., 1996)
      Suppressor of
      Statement
      Reference

      ttk[+]/ttk00219 is a suppressor | partially of ommatidium phenotype of SosJC2, sev6

      (Dong et al., 1999)

      ttk[+]/ttk00219 is a suppressor | partially of photoreceptor cell R7 phenotype of SosJC2, sev6

      (Dong et al., 1999)

      ttk[+]/ttk00219 is a suppressor | partially of ommatidium phenotype of SosJC2/Sos[+], sev6

      (Dong et al., 1999)

      ttk[+]/ttk00219 is a suppressor | partially of photoreceptor cell R7 phenotype of SosJC2/Sos[+], sev6

      (Dong et al., 1999)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of ttk00219/+ to acHw-49c/+ animals leads to an 1.2 enhancement of the ectopic wing margin bristle phenotype. The addition of ttk00219/+ to acHw-1/+ animals leads to an 1.4 enhancement of the ectopic wing margin bristle phenotype. The addition of ttk00219/+ to h41/+ animals leads to a weak ectopic wing margin bristle phenotype.

      (Badenhorst et al., 2002)

      In sev6 hemizygotes that are also heterozygous for SosJC2, 14.7% of ommatidia contain R7 cells. This phenotype is dominantly suppressed by ttk00219.

      (Dong et al., 1999)

      Significant numbers of R7 cells are still formed in ttk00219 flies with a sina2 or sina3 mutant background.

      (Lai et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      A. Spradling.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      E(yan)100D00219
      (Lai et al., 1996)
      l(3)0021900219
      ttk00219
      ttk0219
      (Bai et al., 2001, Okabe et al., 2001, Dong et al., 1999, Lai et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)