FlyBase Allele Report: Dmel\hry[41]

General Information

Symbol

Dmel\hry⁴¹

Species

D. melanogaster

Name

FlyBase ID

FBal0005358

Feature type

allele

Associated gene

Dmel\hry

Associated Insertion(s)

Carried in Construct

Also Known As

h^IL79K, h^IL

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Brown et al., 1991)

antimorphic allele - genetic evidence

(Brown et al., 1995)

loss of function allele

(Long et al., 1996)

Mutagen

PM hybrid dysgenesis

ethyl methanesulfonate

(Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Ingham et al., 1985)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Ingham et al., 1985)

Description

Nucleotide substitution: T?A.

(Wainwright and Ish-Horowicz, 1992)

Amino acid replacement: C114term.

(Wainwright and Ish-Horowicz, 1992)

run protein produced is truncated, consisting of 113 amino acids.

(Brown et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:8,677,751..8,677,751 [+]

Nucleotide change:

T8677751A

Reported nucleotide change:

T?A

Amino acid change:

C114term | h-PA; C114term | h-PB

Reported amino acid change:

C114term

(Wainwright and Ish-Horowicz, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

lethal | recessive

(Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Ingham et al., 1985)

lethal - all die during embryonic stage

(Brown et al., 1995)

pair rule phenotype

(Ingham et al., 1985)

pair rule phenotype | recessive

(Ingham et al., 1985)

some die during embryonic stage

(Brown et al., 1995)

Phenotype Manifest In

haltere & macrochaeta

(Ingham et al., 1985)

head capsule & macrochaeta

(Ingham et al., 1985)

larval abdominal segment 1

(Ingham et al., 1985)

larval abdominal segment 2

(Ingham et al., 1985)

larval abdominal segment 3

(Ingham et al., 1985)

larval abdominal segment 4

(Ingham et al., 1985)

larval abdominal segment 5

(Ingham et al., 1985)

larval abdominal segment 6

(Ingham et al., 1985)

larval abdominal segment 7

(Ingham et al., 1985)

larval abdominal segment 8

(Ingham et al., 1985)

larval head

(Ingham et al., 1985)

larval mesothoracic segment

(Ingham et al., 1985)

larval metathoracic segment

(Ingham et al., 1985)

macrochaeta | ectopic

(Ingham et al., 1985)

rhabdomere

(Brown et al., 1991)

scutellum & macrochaeta

(Ingham et al., 1985)

wing & macrochaeta & adult

(Rushlow et al., 1989)

Detailed Description

Statement

Reference

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

emc¹ h²² clones display differentiated photoreceptors that arise in a more anterior position that in adjacent wild type tissue, the morphogenetic furrow has been shifted anteriorly.

(Brown et al., 1995)

Legs from h^cosh; h^-/h^- adults show a bristle patterning defect that correlates with the expression pattern of h in pupal leg imaginal discs.

(Orenic et al., 1993)

93% of ommatidia in h⁴¹ mutant clones in the eye are defective, with abnormal arrangement of the rhabdomeres.

(Brown et al., 1991)

Parasegment 1 should develop normally, the even-numbered parasegments have only anterior margins that are less sharp and straight compared to wild-type, with the exception of parasegment 8.

(Lawrence and Johnston, 1989)

Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h²⁵, and fails to complement the bristle phenotype of h¹. Homozygous larvae have a typical pair-rule phenotype; the anterior part of each even-numbered abdominal segment and the posterior part of each odd-numbered abdominal segment is deleted. Similar deletions are seen in the thoracic segments and the head. h¹/h⁴¹ flies have ectopic bristles on the scutellum, halteres and head capsule.

(Ingham et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

hry⁴¹ is an enhancer of visible phenotype of Scer\GAL4^455.2, l(1)sc^UAS.cHa

(Rottgen et al., 1998)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

hry⁴¹ has wing margin bristle | ectopic phenotype, non-enhanceable by ttk[+]/ttk¹

(Badenhorst et al., 2002)

hry⁴¹ has wing margin bristle | ectopic phenotype, non-enhanceable by ttk[+]/ttk^1e11

(Badenhorst et al., 2002)

Suppressed by

Statement

Reference

hry⁴¹/h[+], ttk^rM730 has wing margin bristle | ectopic phenotype, suppressible by sc[+]/sc¹

(Badenhorst et al., 2002)

hry⁴¹/h[+], ttk^rM730 has wing margin bristle | ectopic phenotype, suppressible by sc^ase-1/sc[+]

(Badenhorst et al., 2002)

NOT suppressed by

Statement

Reference

hry⁴¹ has wing margin bristle | ectopic phenotype, non-suppressible by ttk[+]/ttk¹

(Badenhorst et al., 2002)

hry⁴¹ has wing margin bristle | ectopic phenotype, non-suppressible by ttk[+]/ttk^1e11

(Badenhorst et al., 2002)

Enhancer of

Statement

Reference

hry⁴¹ is an enhancer of scutellar bristle phenotype of Scer\GAL4^455.2, l(1)sc^UAS.cHa

(Rottgen et al., 1998)

Other

Statement

Reference

CtBP^87De-10, hry⁴¹ has wing margin bristle | ectopic phenotype

(Badenhorst et al., 2002)

Df(3R)awd-KRB/+, hry⁴¹ has wing margin bristle | ectopic phenotype

(Badenhorst et al., 2002)

hry⁴¹, ttk[+]/ttk⁰⁰²¹⁹ has wing margin bristle | ectopic phenotype

(Badenhorst et al., 2002)

hry⁴¹, ttk[+]/ttk^rM730 has wing margin bristle | ectopic phenotype

(Badenhorst et al., 2002)

hry⁴¹, ttk⁰⁰²¹⁹ has wing margin bristle | ectopic phenotype

(Badenhorst et al., 2002)

hry⁴¹/h[+], ttk^rM730 has wing margin bristle | ectopic phenotype

(Badenhorst et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of ttk^rM730/+ or Df(3R)awd-KRB to h⁴¹/+ animals leads to a ectopic wing margin bristle phenotype. The addition of ttk⁰⁰²¹⁹/+ to h⁴¹/+ animals leads to a weak ectopic wing margin bristle phenotype. The addition of ttk^1e11/+ or ttk¹ to h⁴¹/+ animals does not lead to a significant ectopic wing margin bristle phenotype. The addition of sc^ase-1/Y to h⁴¹/+, ttk^rM730/+ animals leads to a complete suppression of the ectopic margin bristle phenotype. The addition ofsc¹/Y to h⁴¹/+, ttk^rM730/+ animals leads to an almost complete suppression of the ectopic margin bristle phenotype. The addition of Df(3R)awd-KRB to h⁴¹/+, ttk^rM730/+ animals leads to a suppression of the ectopic margin bristle phenotype. CtBP^87De-10 combined with h⁴¹ leads to an ectopic margin bristle phenotype.

(Badenhorst et al., 2002)

Mutation enhances the ectopic scutellar bristle phenotype seen from Scer\GAL4^455.2-mediated expression of l(1)sc^Scer\UAS.cHa.

(Rottgen et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

hry⁴¹/hry²⁵ is partially rescued by hry^cosh

(Rushlow et al., 1989)

Comments

The segmentation defect of heterozygote h²⁵/h⁴¹ can be rescued by h^cosh and individuals develop to viable adults, but the strong bristle phenotype is still present.

(Rushlow et al., 1989)

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

5337

P{ftz-lacC}4; hry⁴¹/TM3, Sb¹

3312

hry⁴¹ Diap1^th-1 st¹ opa¹ cu¹ sr¹ e^s ca¹/TM3, Sb¹

Kyoto

106972

hry⁴¹ Diap1^th-1 st¹ opa¹ cu¹ sr¹ e^s ca¹/TM3, Sb¹

101741

ru¹ klar¹ hry⁴¹ / TM3, y⁺ ru¹ klar¹ kni^ri-1 p^p vvl^sep Sb¹ Ubx^bx-34e e^s Ser¹

Notes on Origin

Discoverer

Jurgens.

Comments

Does not behave as a genetic suppressor of faf mutations.

(Huang and Fischer-Vize, 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

1L79k

(Lawrence and Johnston, 1989)

IL79K

(Lawrence and Johnston, 1989)

h⁴¹

h^IL79

(Wainwright and Ish-Horowicz, 1992)

h^IL79K

(Rottgen et al., 1998, Long et al., 1996, Brown et al., 1995, Mohler, 1995, Orenic et al., 1993, Brown et al., 1991, Goto et al., 1989, Hooper et al., 1989, Lawrence and Johnston, 1989, Rushlow et al., 1989, Tremml and Bienz, 1989, Frasch and Levine, 1987, Ingham et al., 1985)

h^IL

(Badenhorst et al., 2002, Cadigan et al., 2002, Coulter and Wieschaus, 1988)

hairy⁴¹

(Cassidy et al., 2019)

hry⁴¹

Name Synonyms

Secondary FlyBase IDs

References (20)

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