FlyBase Allele Report: Dmel\sc[ase-1]

General Information

Symbol

Dmel\sc^ase-1

Species

D. melanogaster

Name

FlyBase ID

FBal0046404

Feature type

allele

Associated gene

Dmel\sc

Associated Insertion(s)

Carried in Construct

Also Known As

ase¹, sc²

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Lindsley and Zimm, 1992)

Progenitor genotype

Caused by aberration

Df(1)ase-1

Cytology

Description

Deletion in the sc regulatory region.

(Gause et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Golovnin et al., 2003)

visible | recessive

(Held, 1990)

Phenotype Manifest In

mechanosensory chaeta | ectopic

(Ayyar et al., 2010)

mesothoracic tarsal bristle

(Held, 1990)

postocellar bristle

(Golovnin et al., 2003)

scutellar bristle

(Golovnin et al., 2003)

Detailed Description

Statement

Reference

sc^ase-1 mutant fles exhibit defects in mechanosensory bristles, including a split shaft, two to three shafts arising from a single socket, an empty socket or a complete duplication.

(Ayyar et al., 2010)

Mutants show loss of the postvertical and scutellar bristles.

(Golovnin et al., 2003)

In female D.simulans/D.melanogaster hybrids heterozygous for sc^ase-1 the anterior scutellar bristle, posterior scutellar bristle, anterior dorsocentral bristle and the posterior dorsocentral bristle are lost at a high frequency compared to female D.simulans/D.melanogaster hybrid controls, when grown at 18^oC.

(Skaer and Simpson, 2000)

The number of bractless bristles on the basitarsi of the second legs is reduced.

(Held, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

sc^ase-1 has visible phenotype, enhanceable by mod(mdg4)^ul/mod(mdg4)^ul

(Golovnin et al., 2003)

Suppressor of

Statement

Reference

sc^ase-1 is a suppressor of visible phenotype of Scer\GAL4^pnr-MD237, tup^RNAi.UAS

(de Navascués and Modolell, 2010)

Other

Statement

Reference

mod(mdg4)^ul, sc^ase-1 has partially lethal phenotype

(Golovnin et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

sc^ase-1 has postocellar bristle phenotype, enhanceable by mod(mdg4)^ul/mod(mdg4)^ul

(Golovnin et al., 2003)

sc^ase-1 has scutellar bristle phenotype, enhanceable by mod(mdg4)^ul/mod(mdg4)^ul

(Golovnin et al., 2003)

sc^ase-1 has phenotype, enhanceable by Df(2R)Jp7/Df(2R)Jp8

(Goulding et al., 2000)

sc^ase-1 has sensory neuron | dorsal phenotype, enhanceable by Df(2R)Jp7/Df(2R)Jp8

(Goulding et al., 2000)

sc^ase-1 has sensory neuron | lateral phenotype, enhanceable by Df(2R)Jp7/Df(2R)Jp8

(Goulding et al., 2000)

Suppressed by

Statement

Reference

sc^ase-1 has mechanosensory chaeta | ectopic phenotype, suppressible by ase^UAS.cBa/Scer\GAL4^hs.PB

(Ayyar et al., 2010)

sc^ase-1 has mechanosensory chaeta | ectopic phenotype, suppressible by Tcas\ase^UAS.cAa/Scer\GAL4^hs.PB

(Ayyar et al., 2010)

sc^ase-1 has mechanosensory chaeta | ectopic phenotype, suppressible by Csal\ASH2^UAS.cAa/Scer\GAL4^hs.PB

(Ayyar et al., 2010)

Suppressor of

Statement

Reference

sc^ase-1 is a suppressor of scutellar bristle | increased number | somatic clone phenotype of tup^ex4

(de Navascués and Modolell, 2010)

sc^ase-1 is a suppressor of scutellar bristle | increased number phenotype of Scer\GAL4^pnr-MD237, tup^RNAi.UAS

(de Navascués and Modolell, 2010)

sc^ase-1/sc[+] is a suppressor of wing margin bristle | ectopic phenotype of hry⁴¹/h[+], ttk^rM730

(Badenhorst et al., 2002)

Other

Statement

Reference

mod(mdg4)^ul, sc^ase-1 has ocellar bristle phenotype

(Golovnin et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of ase^Scer\UAS.cBa under the control of Scer\GAL4^hs.PB suppresses the mechanosensory bristle defects found in sc^ase-1 mutants. The number of defective bristles in sc^ase-1 flies is reduced from an average of 9.7 to 2.5 bristles per fly.

(Ayyar et al., 2010)

Overexpression of tup^{dsRNA.Scer\UAS} under the control of Scer\GAL4^pnr-MD237 in a sc^ase-1 mutant background does not lead to the formation of supernumerary scutellar bristles.

No significant increase in the number of scutellar bristles above the sc^ase-1 background is observed when tup^ex4 clones are induced in a sc^ase-1 mutant background.

(de Navascués and Modolell, 2010)

Df(1)ase-1 ; mod(mdg4)^ul/mod(mdg4)^ul animals show loss of a number of bristles. Bristle pigmentation is normal in these animals.

(Golovnin et al., 2003)

The addition of sc^ase-1/Y to h⁴¹/+, ttk^rM730/+ animals leads to a complete suppression of the ectopic margin bristle phenotype.

(Badenhorst et al., 2002)

The addition of sc^ase-1 strongly enhances the neuronal differentiation defects seen in Df(2R)Jp7/Df(2R)Jp8 embryos. Occasionally it appeared that the scolopale cell was inappropriately stained with neuronal markers. Some cells staining for neuronal markers appear to have lost their distinctive neuronal morphology. These embryos also had defects not seen in Df(2R)Jp7/Df(2R)Jp8 or sc^ase-1 embryos. Neurons of the dorsal and lateral sensory neuron groups have poorly formed or misrouted axons, and in extreme cases axons are entirely missing.

(Goulding et al., 2000)

Xenogenetic Interactions

Statement

Reference

Expression of Tcas\ase^Scer\UAS.cAa under the control of Scer\GAL4^hs.PB suppresses the mechanosensory bristle defects found in sc^ase-1 mutants. The number of defective bristles in sc^ase-1 flies is reduced from an average of 9.7 to 4.9 bristles per fly.

Expression of Zzzz\ASH2^Scer\UAS.cAa under the control of Scer\GAL4^hs.PB suppresses the mechanosensory bristle defects found in sc^ase-1 mutants. The number of defective bristles in sc^ase-1 flies is reduced from an average of 9.7 to 3.9 bristles per fly.

(Ayyar et al., 2010)

Complementation and Rescue Data

Not rescued by

sc^ase-1 is not rescued by sc^UAS.cUa/Scer\GAL4^hs.PB

(Ayyar et al., 2010)

Comments

Expression of sc^Scer\UAS.cUa under the control of Scer\GAL4^hs.PB fails to rescue the mechanosensory bristle defects found in sc^ase-1 mutants.

(Ayyar et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

104

Df(1)ase-1, sc^ase-1 pn¹/C(1)DX, y¹ f¹

Kyoto

105737

Df(1)ase-1, sc^ase-1 pn¹/C(1)DX, y¹ f¹

102029

Df(1)ase-1, sc^ase-1 pn¹ / C(1)DX, y¹ f¹

Notes on Origin

Discoverer

Dubinin, 1928.

(Lindsley and Zimm, 1992)

Comments

The adult phenotype of Df(1)ase-1, except for the mechanosensory bristle aspect, is due to a perturbation of the nearby sc gene: the defect is not complemented by sc^10-1. The mechanosensory bristle aspect of the phenotype is rescued by the P{ase-G:4.8} and P{ase-G:3.5} constructs. The ventral sensillum campaniformium phenotype is partly rescued.

(Jarman et al., 1993)

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