FlyBase Allele Report: Dmel\dos[1.46]

General Information

Symbol

Dmel\dos^1.46

Species

D. melanogaster

Name

FlyBase ID

FBal0051665

Feature type

allele

Associated gene

Dmel\dos

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Herbst et al., 1996)

partially lethal - majority die (with dos^2.42)

(Botham et al., 2008)

some die during larval stage (with dos^2.42)

(Botham et al., 2008)

Phenotype Manifest In

eye

(Herbst et al., 1999)

eye | somatic clone

(Herbst et al., 1996)

photoreceptor

(Herbst et al., 1999)

photoreceptor | somatic clone

(Botham et al., 2008)

photoreceptor cell R7

(Herbst et al., 1999)

Detailed Description

Statement

Reference

dos^1.46/dos^2.42 mutant flies give rise to 33% of the expected number of pupae.

dos^1.46 mutant clones rarely contain photoreceptors and are composed of very few cells.

(Botham et al., 2008)

Heterozygotes exhibit no eye abnormalities. Mitotic clones in the eye are identical to lack of csw function, cells can proliferate but do not differentiate as photoreceptors.

(Herbst et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

dos^1.46/dos^2.42 has partially lethal - majority die | larval stage phenotype, suppressible | partially by Hpyl\cagA^UAS.Tag:HA/Scer\GAL4^hs.PB

(Botham et al., 2008)

NOT Enhancer of

Statement

Reference

dos^1.46 is a non-enhancer of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

dos^1.46 is a non-enhancer of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

NOT Suppressor of

Statement

Reference

dos^1.46 is a non-suppressor of visible phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

dos^1.46 is a non-suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

dos^1.46 has photoreceptor | somatic clone phenotype, suppressible by Hpyl\cagA^UAS.Tag:HA/Scer\GAL4^GMR.PF

(Botham et al., 2008)

Enhancer of

Statement

Reference

dos^1.46 is an enhancer of eye phenotype of csw^CS.hs.2sev

(Herbst et al., 1999)

dos^1.46 is an enhancer of ommatidium phenotype of csw^CS.hs.2sev

(Herbst et al., 1999)

dos^1.46 is an enhancer of phenotype of csw^CS.hs.2sev

(Herbst et al., 1996)

NOT Enhancer of

Statement

Reference

dos^1.46 is a non-enhancer of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

dos^1.46 is a non-enhancer of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

dos^1.46 is a non-enhancer of eye phenotype of Ras85D^V12

(Herbst et al., 1996)

dos^1.46 is a non-enhancer of eye phenotype of Raf::tor^13D.hs.sev

(Herbst et al., 1996)

Suppressor of

Statement

Reference

dos^1.46 is a suppressor of phenotype of csw::Src64B^hs.2sev

(Herbst et al., 1996)

dos^1.46 is a suppressor of phenotype of sev^S11.Tag:MYC

(Herbst et al., 1996)

NOT Suppressor of

Statement

Reference

dos^1.46 is a non-suppressor of eye phenotype of CanB^GMR.PS, Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

dos^1.46 is a non-suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

dos^1.46 is a non-suppressor of eye phenotype of Ras85D^V12

(Herbst et al., 1996)

dos^1.46 is a non-suppressor of eye phenotype of Raf::tor^13D.hs.sev

(Herbst et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype seen in csw^CS.hs.2sev flies is enhanced by the addition of dos^1.46. The addition of dos^hs.2sev.cHa or dos^YY.hs.2sev to csw^CS.hs.2sev/dos^1.46 flies strongly suppresses this phenotype. The addition of dos^{Y854F.hs.2sev}, dos^{Y801F.hs.2sev.cHa}, or dos^{Y810F.Y854F.hs.2sev} leads to markedly enhanced eye roughness.

(Herbst et al., 1999)

Xenogenetic Interactions

Statement

Reference

Expression of Zzzz\cagA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hs.PB suppresses the lethality seen in dos^1.46/dos^2.42 mutants. 89% of the expected number of pupae are seen, compared to only 33% in homozygous dos^1.46 mutants.

Expression of Zzzz\cagA^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF increases dos^1.46 mutant clone size in the eye. The clones are much larger and contain increased numbers of photoreceptors.

(Botham et al., 2008)

Complementation and Rescue Data

Rescued by

dos^1.46/dos^2.42 is rescued by Scer\GAL4^GMR.PF/dos^UAS.cRa

(Botham et al., 2008)

dos^1.46/dos^2.42 is rescued by dos^YY.hs.2sev

(Herbst et al., 1999)

Partially rescued by

dos^1.46/dos^2.42 is partially rescued by dos^YY.hs.2sev

(Herbst et al., 1999)

dos^1.46/dos^2.42 is partially rescued by dos^hs.2sev.cHa

(Herbst et al., 1999)

Comments

Expression of dos^Scer\UAS.cRa under the control of Scer\GAL4^GMR.PF increases dos^1.46 mutant clone size in the eye. The clones are much larger and contain increased numbers of photoreceptors.

(Botham et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dos^1.46

(Botham et al., 2008, Settle et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close