FB2024_03 , released June 25, 2024
Allele: Hpyl\cagAUAS.Tag:HA
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General Information
Symbol
Hpyl\cagAUAS.Tag:HA
Species
H. pylori
Name
FlyBase ID
FBal0321250
Feature type
allele
Associated gene
Hpyl\cagA
Associated Insertion(s)
Carried in Construct
P{UAS-cagA.HA}
Transgenic product class
wild_type
(Botham et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Botham et al., 2008)
Mutagen
in vitro construct
(Botham et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-cagA.HA}
Cytology
Description

UASt regulatory sequences drive expression of Hpyl\cagA tagged at the N-terminal end with Tag:HA.

(Botham et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hpyl\cagA
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF results in disorganisation of the retinal epithelium. The normal crystalline structure of the ommatidium is disturbed and normal cell shapes and neighbour relationships are perturbed. The phenotype is dosage-dependent, appearing more severe in flies expressing two copies of Zzzz\cagAScer\UAS.T:Ivir\HA1 compared to one copy.

      (Botham et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Hpyl\cagAUAS.Tag:HA/Scer\GAL4GMR.PF is a suppressor of photoreceptor | somatic clone phenotype of dos1.46

      (Botham et al., 2008)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.PB suppresses the lethality seen in dos1.46/dos2.42 mutants. 89% of the expected number of pupae are seen, compared to only 33% in homozygous dos1.46 mutants.

      Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF increases dos1.46 mutant clone size in the eye. The clones are much larger and contain increased numbers of photoreceptors.

      Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of either Scer\GAL4GMR.PF or Scer\GAL4hs.PB does not significantly increase the number of photoreceptors seen in csw13-87 mutant larval eye discs.

      Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of either Scer\GAL4GMR.PF or Scer\GAL4hs.PB does not significantly increase the number of photoreceptors seen in csw1 mutant larval eye discs.

      (Botham et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hpyl\cagAScer\UAS.T:Ivir\HA1
      Hpyl\cagAUAS.Tag:HA
      Zzzz\cagAScer\UAS.T:Ivir\HA1
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0320636
      • FBal0280226
      References (2)