FlyBase Allele Report: Dmel\csw[13-87]

General Information

Symbol

Dmel\csw^13-87

Species

D. melanogaster

Name

FlyBase ID

FBal0030970

Feature type

allele

Associated gene

Dmel\csw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Allard et al., 1996, Perkins et al., 1992)

Mutagen

spontaneous

(Perkins et al., 1996, Perkins et al., 1992)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | germline clone | rescuable maternal effect

(Perkins et al., 1996)

lethal | pupal stage | recessive

(Perkins et al., 1996)

lethal | recessive

(Allard et al., 1998)

lethal - all die before end of pupal stage

(Perkins et al., 1992)

some die during pupal stage

(Perkins et al., 1992)

Phenotype Manifest In

embryonic/first instar larval cuticle | germline clone

(Perkins et al., 1996)

photoreceptor | larval stage

(Botham et al., 2008)

Detailed Description

Statement

Reference

In the larval eye discs of csw^13-87 mutants only a few photoreceptors develop along the morphogenetic furrow. The residual photoreceptors are mostly R8 cells.

(Botham et al., 2008)

csw^13-87/Y males carrying csw^R32K.hs.2sev or csw^{R137K.hs.2sev} have smooth eyes with normally constructed ommatidia.

(Allard et al., 1998)

Has no "Enhancer of sev" activity. Clones of mutant cells induced during the first larval instar only rarely develop photoreceptors.

(Allard et al., 1996)

csw^13-87 germline clone mosaics cause maternal effect lethality. Embryos derived from mothers with germline clones that exhibit a corkscrew cuticle phenotype (71%) have slight paternal rescue of the germline clone phenotype, embryos that do not receive a wild type copy from their father (29%), null embryos, die with a 'U'-shaped cuticle phenotype.

(Perkins et al., 1996)

Abnormal development of terminal internal structures. Syncytial and cellular blastoderm embryos show reduced posterior tll domain. hb remains as a posterior cap and the seventh ftz stripe expands posteriorly, both due to lack of hkb repressing activity.

(Perkins et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

csw^13-87 has phenotype, suppressible by csw::Src64B^hs.2sev

(Allard et al., 1998)

NOT suppressed by

Statement

Reference

csw^13-87 has photoreceptor | larval stage phenotype, non-suppressible by Hpyl\cagA^UAS.Tag:HA/Scer\GAL4^GMR.PF

(Botham et al., 2008)

csw^13-87 has photoreceptor | larval stage phenotype, non-suppressible by Hpyl\cagA^UAS.Tag:HA/Scer\GAL4^hs.PB

(Botham et al., 2008)

csw^13-87 has phenotype, non-suppressible by csw::Src64B^{C583S.hs.2sev}

(Allard et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Zzzz\cagA^{Scer\UAS.T:Ivir\HA1} under the control of either Scer\GAL4^GMR.PF or Scer\GAL4^hs.PB does not significantly increase the number of photoreceptors seen in csw^13-87 mutant larval eye discs.

(Botham et al., 2008)

Complementation and Rescue Data

Rescued by

csw^13-87 is rescued by csw^Δin.hs.2sev

(Allard et al., 1998)

csw^13-87 is rescued by csw^{Δtail.hs.2sev}

(Allard et al., 1998)

csw^13-87 is rescued by csw^R32K.hs.2sev

(Allard et al., 1998)

csw^13-87 is rescued by csw^{R137K.hs.2sev}

(Allard et al., 1998)

csw^13-87 is rescued by csw^hs.2sev

(Allard et al., 1998)

Partially rescued by

csw^13-87 is partially rescued by csw^UAS.Tag:FLAG/Scer\GAL4^GMR.PF

(Botham et al., 2008)

csw^13-87 is partially rescued by csw^UAS.Tag:FLAG/Scer\GAL4^hs.PB

(Botham et al., 2008)

Not rescued by

csw^13-87 is not rescued by csw^{G547E.hs.2sev}

(Allard et al., 1998)

csw^13-87 is not rescued by csw^{SH2SH2.hs.2sev}

(Allard et al., 1998)

csw^13-87 is not rescued by csw^CS.hs.2sev

(Allard et al., 1998)

csw^13-87 is not rescued by csw^{R32K.R137K.hs.2sev}

(Allard et al., 1998)

Comments

Expression of csw^{Scer\UAS.T:Zzzz\FLAG} under the control of either Scer\GAL4^GMR.PF or Scer\GAL4^hs.PB significantly increases the number of photoreceptors seen in csw^13-87 mutant larval eye discs.

(Botham et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Phenotypic series of csw mutant embryos derived from homozygous germline clones, classified according to cuticular phenotype: csw⁵ = csw^LE120 > csw¹ = csw^13-87 > csw^e13d.3 > csw⁷ = csw⁶.

(Perkins et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

csw^13-87

(Botham et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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