FB2024_03 , released June 25, 2024
Allele: Dmel\tws60
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General Information
Symbol
Dmel\tws60
Species
D. melanogaster
Name
FlyBase ID
FBal0035891
Feature type
allele
Associated gene
Dmel\tws
Associated Insertion(s)
P{?lacW}tws60
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Uemura et al., 1993)
Progenitor genotype
twsj11C8
(Uemura et al., 1993)
Associated Insertion(s)
P{?lacW}tws60
Cytology
Description

Internal deletion of the P{lacW} insertion.

(Uemura et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The number of neuroblasts in mutant brains is slightly increased compared to wild type.

      The mitotic spindle is misaligned with the cortical crescent in some tws02414/tws60 neuroblasts.

      (Wang et al., 2009)

      tws60 homozygous animals die during early pupal stages. twsScer\UAS.cBa; Scer\GAL4hs.PB; tws60/tws60 animals have scattered ectopic bristles on their wing blades.

      (Bajpai et al., 2004)

      Wing discs exhibit unusual outgrowths in the posterior compartment, this overgrown region resembles the wing pouch. Similar outgrowths are seen on the haltere disc. Eye-antennal and leg defects exhibit no defects.

      (Uemura et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      One copy of tws60 partially suppresses the reduction in eye size seen when Zzzz\E4orf4Scer\UAS.cPa is expressed under the control of Scer\GAL4GMR.PF. Eyes are of wild type size in females, but only 82% in males.

      One copy each of twsaar-1 and tws60 completely suppresses the reduction in eye size seen when Zzzz\E4orf4Scer\UAS.cPa is expressed under the control of Scer\GAL4GMR.PF.

      One copy of tws60 partially suppresses the wing phenotype seen when Zzzz\E4orf4Scer\UAS.cPa is expressed under the control of Scer\GAL4en.PU at 29[o]C. Loss of the posterior part of the wing is seen in 8% of flies, compared to 100% when Zzzz\E4orf4Scer\UAS.cPa is expressed alone. Many wings exhibit more minor phenotypes and in 11% of flies the wings appear wild type.

      One copy of tws60 partially suppresses the wing disc phenotype seen when Zzzz\E4orf4Scer\UAS.cPa is expressed under the control of Scer\GAL4en.PU at 29[o]C. Only 30% of wing discs contain a cluster of dead cells, compared to 100% when Zzzz\E4orf4Scer\UAS.cPa is expressed alone.

      (Pechkovsky et al., 2013)
      Complementation and Rescue Data
      Partially rescued by

      tws60 is partially rescued by twsUAS.cBa/Scer\GAL4hs.PB

      (Bajpai et al., 2004)
      Comments

      twsScer\UAS.cBa; Scer\GAL4hs.PB rescues survival of tws60 to the pharate adult stage, with no obvious morphological defects apart from scattered ectopic bristles on the wing blades.

      (Bajpai et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Uemura.

      (Uemura et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      tws60
      (Pechkovsky et al., 2013)
      tws60
      (Rui et al., 2020, Kim et al., 2019, Rosen et al., 2019, Pechkovsky et al., 2013, Wang et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)