FlyBase Allele Report: Dmel\if[C.UAS]

General Information

Symbol

Dmel\if^C.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0051513

Feature type

allele

Associated gene

Dmel\if

Associated Insertion(s)

Carried in Construct

P{UAS-if.C}

Key Links

Transgenic product class

cDNA

(Brabant et al., 1996)

wild_type

(Brabant et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Brabant et al., 1996)

wild_type

(Brabant et al., 1996)

Mutagen

in vitro construct

(Hoang and Chiba, 1998, Martin-Bermudo et al., 1997, Brabant et al., 1996, Roote and Zusman, 1996)

Progenitor genotype

Carried in construct

P{UAS-if.C}

Cytology

Description

UASt regulatory sequences drive expression of cDNA sequences encoding the if 'c' splice variant.

(Brabant et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye, with Scer\GAL4^how-24B

(Roote and Zusman, 1996)

Detailed Description

Statement

Reference

When if^C.Scer\UAS is driven by Scer\GAL4^30A, no effect on wing morphology is seen.

(Kiger et al., 2001)

Embryos expressing if^C.Scer\UAS under the control of Scer\GAL4^elav-C155 do not show axon defects in the central or peripheral nervous systems.

(Hoang and Chiba, 1998)

Scer\GAL4^how-24B mediated expression of if^C.Scer\UAS causes a dominant eye phenotype.

(Roote and Zusman, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^48Y/if^C.UAS is a suppressor of lethal phenotype of mew^M6

(Martin-Bermudo et al., 1997)

Phenotype Manifest In

Suppressor of

Statement

Reference

if^C.UAS/Scer\GAL4^hs.PB is a suppressor of photoreceptor neuron phenotype of mew⁴⁹⁸

(Li et al., 1998)

if^C.UAS/Scer\GAL4^hs.PB is a suppressor of retina | somatic clone phenotype of mew⁴⁹⁸

(Roote and Zusman, 1996)

if^C.UAS/Scer\GAL4^hs.PB is a suppressor of retina | somatic clone phenotype of mew^M6

(Roote and Zusman, 1996)

NOT Suppressor of

Statement

Reference

Scer\GAL4⁶⁸⁴/if^C.UAS is a non-suppressor of wing | somatic clone phenotype of mew⁴⁹⁸

(Brabant et al., 1996)

Scer\GAL4⁶⁸⁴/if^C.UAS is a non-suppressor of wing | somatic clone phenotype of mew^M6

(Brabant et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

mew⁴⁹⁸ clones in the eye disrupt photoreceptor organisation. Scer\GAL4^hs.PB-mediated expression of if^C.Scer\UAS allows some rescue of the phenotype.

(Li et al., 1998)

Partially rescues the first instar lethality of mew^M6 homozygotes when expressed using Scer\GAL4^48Y, although the animals do not survive past the second larval instar stage.

(Martin-Bermudo et al., 1997)

Scer\GAL4⁶⁸⁴ induced expression of if^C.Scer\UAS fails to rescue the blistering phenotype of dorsal mew^M6 or mew⁴⁹⁸ clones.

(Brabant et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^how-24B/if^C.UAS rescues if^k27e

(Li et al., 1998)

Scer\GAL4^twi.PG, Scer\GAL4^how-24B, if^C.UAS rescues if^B4

(Martin-Bermudo et al., 1997)

Scer\GAL4⁶⁸⁴/if^C.UAS rescues if^A7

(Brabant et al., 1996)

Scer\GAL4^how-24B/if^C.UAS rescues if^k27e

(Roote and Zusman, 1996)

Partially rescues

Scer\GAL4^elav.PLu/if^C.UAS partially rescues if^k27e

(Hoang and Chiba, 1998)

Comments

Scer\GAL4⁶⁸⁴ induced expression of if^C.Scer\UAS rescues if^A7 ventral clones completely.

(Brabant et al., 1996)

The lethality caused by if^k27e can be rescued by Scer\GAL4^how-24B mediated expression of one copy of P{UAS-if.C}, a copy of both P{UAS-if.C} and P{UAS-if.m8} or two copies either P{UAS-if.C}. Adult survivors carrying one copy of P{UAS-if.C} exhibit wing blisters at a higher frequency than the other survivors.

(Roote and Zusman, 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

if^C.Scer\UAS

if^C.UAS

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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