FB2024_03 , released June 25, 2024
Allele: Dmel\ttkp88.UAS
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General Information
Symbol
Dmel\ttkp88.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0060850
Feature type
allele
Associated gene
Dmel\ttk
Associated Insertion(s)
Carried in Construct
P{UAS-ttk.p88}
Also Known As
UAS-ttk88
Key Links
Transgenic product class
cDNA
(Giesen et al., 1997)
wild_type
(Giesen et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Giesen et al., 1997)
wild_type
(Giesen et al., 1997)
Mutagen
in vitro construct
(Giesen et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-ttk.p88}
Cytology
Description

UASt regulatory sequences drive expression of a cDNA clone expressing the p88 isoform of ttk.

(Giesen et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ttk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ttkp88.Scer\UAS under the control of Scer\GAL4twi.PB and Scer\GAL4how-24B does not lead to an obvious adult phenotype, as compared to controls.

      (Ciglar et al., 2014)

      Scer\GAL4hs.2sev-mediated expression of ttkp88.Scer\UAS induces the loss of at least one cone cell in about 90% of the ommatidia.

      (Shi and Noll, 2009)

      Has no effect on mushroom body development when driven by Scer\GAL4c739.

      (Nicolai et al., 2003)

      When ttkp88.Scer\UAS is driven by Scer\GAL4Bx-MS1096 all dorsal chemosensory bristles are removed within the triple row, but the ventral chemosensory and medial mechanosensory bristles numbers are merely reduced. No effect is seen on wing blade area and cell proliferation.

      (Badenhorst et al., 2002)

      Expression of ttkp88.Scer\UAS under the control of Scer\GAL4GMR.PF does not abolish the second mitotic wave in the eye disc.

      (Baonza et al., 2002)

      Flies expressing ttkp88.Scer\UAS under the control of Scer\GAL4cb19 are moderately viable.

      (Ward et al., 2002)

      Expression of ttkp88.Scer\UAS under the control of Scer\GAL4dpp.blk1 has no effect on furrow initiation in the eye disc.

      (Kumar and Moses, 2001)

      The polar and equatorial cone cells are not present in any 12-cell stage ommatidia in eye discs expressing ttkp88.Scer\UAS under the control of Scer\GAL4hs.2sev (the four cone cells have normally been recruited by this stage in wild-type discs). Instead, R3 and R4 photoreceptor cells adopt an abnormally apical position within each ommatidium.

      (Xu et al., 2000)

      Scer\GAL4Kr.PM-mediated expression leads to a partial block of neuronal development in the PNS but no obvious defects in the CNS.

      (Giesen et al., 1997)

      The external facet array is disorganised and all bristles are missing in the eyes of flies expressing ttkp88.Scer\UAS under the control of Scer\GAL4GMR.PF. No photoreceptors are seen and the remaining tissue is vacuolated. Lenses are present on the eye surface. The external facet array is moderately disrupted and some bristles are present in the eyes of flies expressing ttkp88.Scer\UAS under the control of Scer\GAL4hs.2sev. Ommatidia usually contain 4 outer photoreceptors and 1 central photoreceptor, which is an R8 cell.

      (Li et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      ttkp88.UAS has cone cell | pupal stage | increased number phenotype, enhanceable by Scer\GAL4hs.2sev, ttkp88.UAS

      (Shi and Noll, 2009)
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ttkp88.Scer\UAS Scer\GAL4hs.2sev, svsev.PS pupal eye discs have additional cone cells in about 40% of their ommatidia , with a maximum of seven cone cells observed in 1% of the ommatidia.

      One supernumerary cone cell is generated in most ttkp88.Scer\UAS Scer\GAL4hs.2sev, svsev.PS ommatidia, while up to three additional cone cells are generated in only 4% of the ommatidia.

      (Shi and Noll, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      ttkp88.UAS/Scer\GAL4hs.PB fails to rescue ttktwp/ttk1e11

      (French et al., 2003)
      Comments

      ttkp88.Scer\UAS (driven by Scer\GAL4hs.PB fails to rescue the chorion and dorsal appendage phenotypes of ttktwp/ttk1e11 eggs under any heat shock conditions.

      (French et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ttkp88.Scer\UAS
      ttkp88.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (18)