FB2024_03 , released June 25, 2024
Allele: Scer\GAL4GH298
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General Information
Symbol
Scer\GAL4GH298
Species
S. cerevisiae
Name
FlyBase ID
FBal0061905
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GawB}GH298
Carried in Construct
Also Known As
GH298-Gal4, GH298, GAL4-GH298, GH298Gal4
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Stocker et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{GawB}GH298
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      intrinsic neuron of embryonic/larval antennal lobe
      (Thum et al., 2011)
      pupal stage
      antennal lobe
      (Stocker et al., 1997)
      adult stage
      gnathal ganglion
      (Stocker et al., 1997)
      antenna
      (Hummel and Zipursky, 2004)
      olfactory receptor neuron of antenna | subset
      (Hummel and Zipursky, 2004)
      antennal lobe glomerulus V
      (Hummel and Zipursky, 2004)
      olfactory receptor neuron | subset
      (Hummel and Zipursky, 2004)
      GABAergic local interneuron of the adult antennal lobe
      (Acebes et al., 2011, Wilson and Laurent, 2005)
      adult antennal lobe projection neuron | subset
      (Chou et al., 2010)
      adult olfactory receptor neuron | subset
      (Chou et al., 2010)
      GABAergic local interneuron of the adult antennal lobe | subset

      Comment: 24 of 28 labeled neurons

      (Chou et al., 2010, Lai et al., 2008)
      cholinergic local interneuron of the adult antennal lobe | subset

      Comment: 1 of 28 labeled neurons

      (Chou et al., 2010)
      adult antennal lobe local neuron
      (Scheunemann et al., 2019, Chou et al., 2010)
      GABAergic neuron | subset
      (Shang et al., 2007)
      cholinergic neuron | subset
      (Shang et al., 2007)
      adult antennal lobe projection neuron lPN | subset
      (Lai et al., 2008)
      adult antennal lobe local neuron | subset

      Comment: 30-32 per antennal lobe

      (Acebes et al., 2011)
      adult antennal lobe
      (Stocker et al., 1997)
      adult gnathal ganglion serotonergic projection neuron
      (Scheunemann et al., 2019)
      adult neuron | subset of adult brain
      (Scheunemann et al., 2019)
      Additional Information
      Statement
      Reference

      Drives expression in mostly GABAergic antennal lobe local interneurons, and in a subset of olfactory projection neurons and olfactory receptor neurons.

      (FlyBase Curators, 2017)

      ScerGAL4GH298 drives expression in neurons with cell bodies located lateral to the antennal lobes (AL). Some of the labeled neurons innervate the AL.

      (Thum et al., 2011)

      ScerGAL4GH298 is expressed in 30-32 local neurons of the antennal lobe, with almost all being GABAergic.

      (Acebes et al., 2011)

      Expression of ScerGAL4GH298 is seen in cell bodies found in the local interneuron cluster located lateral and dorsolateral to the antennal lobe. Most labelled cells are ipsilaterally projecting interneurons.

      (Chou et al., 2010)

      ScerGAL4H24 drives expression in mostly GABAergic antennal lobe local interneurons, and in a subset of olfactory projection neurons and olfactory receptor neurons.

      (Chou et al., 2010)

      There are an average 21 ScerGAL4GH298-positive lPN cells.

      (Lai et al., 2008)

      An estimated 81% cells expressing ScerGAL4GH298 are GABAergic.

      (Shang et al., 2007)

      The neurites of the AL LNs collectively fill the antennal lobes. Expression of ScerGAL4GH298 generally colocalizes with GABA-immunoreactivity, though approximately one-fifth of the GFP positive cells are not GABA-immunopositive.

      (Wilson and Laurent, 2005)

      In adult brain, expression observed in about 20 neurons with arborization in the antennal lobe (AL), most with cell bodies lateral to the AL; pattern fits the shape of 'LocI' (FBrf0051437); expression observed in a subset of neurons in the subesophageal ganglion. No expression observed in the AL in third instar larvae or early pupae; starts to develop at 48h APF.

      (Stocker et al., 1997)
       
      Marker for
      antennal lobe glomerulus V
      (Hummel and Zipursky, 2004)
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      GAL4GH298
      Scer\GAL4GH298
      Name Synonyms
      Secondary FlyBase IDs
        References (37)