FB2024_03 , released June 25, 2024
Allele: Dmel\ConUAS.cRa
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General Information
Symbol
Dmel\ConUAS.cRa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Raghavan
FlyBase ID
FBal0062021
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-connectin, UAS-Con
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

4.5kb Con cDNA is expressed under the control of UASt regulatory sequences.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Muscles 15,16 and 17 appear stuck together (they are not fused) when ConScer\UAS.cRa is expressed in embryos using Scer\GAL4how-24B. The gap between muscles 12 and 13 is abolished in embryos expressing ConScer\UAS.cRa under the control of Scer\GAL4how-24B. The lateral transverse muscles appear normal in these embryos. Muscles 12 and 13 are either stuck together or more closely apposed than normal in larvae derived from embryos expressing ConScer\UAS.cRa under the control of Scer\GAL4how-24B, however their locomotion appears normal. The segmental motor nerve branch b (SNb) is abnormal in embryos expressing ConScer\UAS.cRa under the control of Scer\GAL4how-24B; the SNb enters the ventral muscle field at the normal location but in 22% of cases the SNb stops at the level of muscles 6 and 7, in 70% of cases it extends fairly normally over muscles 6 and 7 but fails to reach muscle 12 and in 8% of cases it reaches muscle 12 but does not innervate it. In those cases where the SNb progresses at least to the level of muscle 13, the RP3 neuron is either present but fails to reach its synaptic target site (75% of cases) or is absent (25% of cases). The segmental motor nerve branch d (SNd) fails to grow out in more than 80% of cases in embryos expressing ConScer\UAS.cRa under the control of Scer\GAL4how-24B. Segmental motor nerve branches a and c (SNa and SNc) appear normal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of ConScer\UAS.cRa under the control of Scer\GAL4ap-md544 does not restore a smooth boundary between the dorsal and ventral cells in apmd544/apUGO35 wing discs.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
ConScer\UAS.cRa
ConUAS.cRa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Raghavan
Secondary FlyBase IDs
    References (5)