FlyBase Allele Report: Dmel\Egfr[k05115]

General Information

Symbol

Dmel\Egfr^k05115

Species

D. melanogaster

Name

FlyBase ID

FBal0065256

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

P{lacW}Egfr^k05115

Carried in Construct

Also Known As

k05115, l(2)k05115

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Egfr^k05115

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Dworkin and Gibson, 2006, Spradling et al., 1999)

lethal - all die during embryonic stage | recessive

(Liu et al., 1999)

some die during embryonic stage | recessive

(Liu et al., 1999)

visible | dominant

(Dworkin and Gibson, 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

Egfr^k05115 mutants exhibit defects in terminal cell lumenogenesis, with terminal cells lacking a visible gas-filled lumen and exhibiting some branching defects. Only a small percentage (approximately 15%) of Egfr^k05115 mutant terminal cells exhibit defective lumen.

(Ruiz et al., 2012)

Homozygous clones in the eye disc grow poorly and are very small.

(Tseng et al., 2007)

Heterozygotes show a direct effect on the shape of the wing.

(Dworkin and Gibson, 2006)

Malpighian tubules are very reduced in mutant embryos. Midgut constrictions do not form. There is a failure in germ band retraction and dorsal closure. Salivary glands are short. No head epithelium is present.

(Liu et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Egfr[+]/Egfr^k05115 is a non-suppressor of lethal phenotype of Uba1^B1/Uba1^B2

(Yan et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

Egfr[+]/Egfr^k05115 is an enhancer of dorsal appendage phenotype of Ras85D^ix12a

(Schnorr et al., 2001)

Suppressor of

Statement

Reference

Egfr[+]/Egfr^k05115 is a suppressor of embryonic/larval tracheal system phenotype of Ptp10D¹, Ptp4E¹

(Jeon and Zinn, 2009)

Additional Comments

Genetic Interactions

Statement

Reference

A Egfr^k05115/+ background does not suppress the ectopic cell divisions found in Uba1^B1/Uba1^B2 trans-heterozygous eye discs.

(Yan et al., 2009)

Strong dominant enhancer of the Ras85D^ix12a eggshell phenotype; 0-20% of dorsal appendages are wild type.

(Schnorr et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Egfr^unspecified

(Dworkin and Gibson, 2006)

Egfr^f2

(Liu et al., 1999)

Egfr⁰³⁰³³

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

10385

y¹ w^67c23; P{lacW}Egfr^k05115/CyO

Kyoto

111078

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}Egfr^k05115 /CyO y⁺

Notes on Origin

Discoverer

I. Kiss.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

EGFR^k05115

(Ruiz et al., 2012)

Egfr^k05115

(Stamm et al., 2019, Salzer et al., 2010, Jeon and Zinn, 2009, Yan et al., 2009, Tseng et al., 2007, Dworkin and Gibson., 2006)

egfR^k05115

(Levayer et al., 2011)

egfr^k05115

(Tsarouhas et al., 2019)

k05115

(Dworkin et al., 2011, Dworkin and Gibson, 2006, Liu et al., 1999)

l(2)k05115

(Schnorr et al., 2001, Spradling et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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