FlyBase Allele Report: Dmel\Csk[S030003]

General Information

Symbol

Dmel\Csk^S030003

Species

D. melanogaster

Name

FlyBase ID

FBal0082747

Feature type

allele

Associated gene

Dmel\Csk

Associated Insertion(s)

P{lacW}Csk^S030003

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Read et al., 2004)

Mutagen

Delta2-3 transposase

(Deak et al., 1997)

P-element activity

(Szeged Stock Center, 1998-)

Progenitor genotype

Associated Insertion(s)

P{lacW}Csk^S030003

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:11,649,247..11,649,247

(Read et al., 2004, Deak, 1999.12.22, Szeged Stock Center, 1998-, Deak et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye | somatic clone

(Read et al., 2004)

eye disc | somatic clone

(Vidal et al., 2006)

eye disc morphogenetic furrow | larval stage (with Csk^j1D8)

(Read et al., 2004)

interommatidial cell | pupal stage (with Csk^j1D8)

(Read et al., 2004)

ommatidium | somatic clone | increased number

(Read et al., 2004)

wing disc | somatic clone

(Vidal et al., 2006)

Detailed Description

Statement

Reference

Csk^S030003/Csk^S030003 somatic clones in third instar wings or eye discs are small only and rarely survive in pupal eye discs at 42 hours after puparium formation.

(Vidal et al., 2006)

Homozygous mutant clones in the eye produced severely overgrown eyes. Eyes have about 894 ommatidia, compared to about 687 in wild-type.

(Read et al., 2004)

Lethality acts in the pupal and pharate adult stages.

(Deak et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, suppressible by Btk^k00206

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, suppressible by Src64B^PI

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, suppressible by bsk¹

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, suppressible | partially by Src42A^18-2

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has abnormal mitotic cell cycle phenotype, suppressible by Btk^k00206

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has increased occurrence of cell division phenotype, suppressible by bsk¹

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has increased occurrence of cell division phenotype, suppressible by Btk^k00206

(Read et al., 2004)

NOT suppressed by

Statement

Reference

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by CadN^M12

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by Egfr^f2

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by Jra^IA109

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by Sos^34Ea-6

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by Src42A^Su(Raf)1-1

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by Src42A^k10108

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by chico¹

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by ft^G-rv

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by scb²

(Read et al., 2004)

Csk^j1D8/Csk^S030003 has lethal | pupal stage phenotype, non-suppressible by shg^k03401

(Read et al., 2004)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Csk^j1D8, Stat92E^j6C8 mutant eyes are smaller than eyes mutant for Csk^j1D8 or Stat92E^j6C8 alone. In addition, adult eyes are frequently fragmented, with scars and/or patches of eye tissue separated by patches of cuticle.

(Read et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Csk^hs.PR

(Read et al., 2004)

Csk^j1D8

(Read et al., 2004)

Rescued by

Csk^S030003 is rescued by Csk^hs.PR

(Read et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Lethality is revertable on excision of the P{lacW}.

(Read et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

300/3

(Deak et al., 1997)

Csk^S030003

S030003

(Read et al., 2004)

dCsk^S030003

(Read et al., 2004)

dCsk^SO300003

(Vidal et al., 2006)

l(3)S017909^S030003

(Deak, 1999.12.22)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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