FlyBase Allele Report: Dmel\drl[P1]

General Information

Symbol

Dmel\drl^P1

Species

D. melanogaster

Name

FlyBase ID

FBal0093077

Feature type

allele

Associated gene

Dmel\drl

Associated Insertion(s)

P{lacW}pigeon^P1

Carried in Construct

Also Known As

lio¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Dura et al., 1995)

Progenitor genotype

Associated Insertion(s)

P{lacW}pigeon^P1

Cytology

Description

P{lacW} is inserted between nucleotides 449 and 450 (where the drl transcription start site is at nucleotide 487). The insertion sites of P{etau-lacZ}drl^P3.765 and P{lacW}pigeon^P1 are identical.

(Taillebourg and Dura, 1999)

The P{etau-lacZ}drl^P3.765 insertion in drl^P3.765 is inserted at the same nucleotide as the P{lacW}pigeon^P1 insertion.

(Moreau-Fauvarque et al., 1998)

Insertion of P{lacW} between pigeon and drl, in the 5' non-coding region of drl.

(Dura et al., 1995)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:19,190,341..19,190,341 [+]

(Hitier et al., 2000, Taillebourg and Dura, 2000, Taillebourg and Dura, 1999, Tully, 1999.7.2, Moreau-Fauvarque et al., 1998, Simon et al., 1998, Bolwig et al., 1995, Dura et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | progressive

(Tamura et al., 2003)

abnormal neuroanatomy (with drl^R343)

(Reynaud et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

drl^P1/drl^R343 mushroom body α axons can show either mistargeting or aberrant midline crossing, but not both phenotypes together.

(Reynaud et al., 2015)

Mutant animals show decreased 1 hour memory that is further reduced by aging.

(Tamura et al., 2003)

Homozygotes display very weak adult brain defects. In about 5% of flies, fibres abnormally cross the midline above the fan-shaped body. The β lobes are partially fused in about a quarter of flies.

(Hitier et al., 2001)

The fan-shaped body is sometimes slightly flattened at the top compared to wild-type in homozygous adults. A cluster of cell bodies reaches the top of the fan-shaped body, but the number of cell bodies in this cluster can be strongly reduced. A partial fusion of the β lobes is seen in about 70% of animals. The α lobes appear thinner than wild-type in some flies.

(Moreau-Fauvarque et al., 1998)

In contrast to lack of brain defects reported in FBrf0083785, P{lacW}pigeon^P1/Df(2L)VA12 adults show brain defects. The fan-shaped body is distorted on its dorsal side, where axonal structures replace cell bodies. The α lobes of the mushroom bodies are reduced and the β lobes are fused or juxtaposed. Mutant flies show some pupal lethality, indicating a developmental defect as well as a learning and memory defect for the P{lacW}pigeon^P1 chromosome.

(Simon et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

cas³⁹²¹, drl^P1 has partially lethal phenotype

(Hitier et al., 2001)

cas³⁹²¹, drl^P1 has viable | poor phenotype

(Hitier et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

drl^P1 has adult mushroom body beta'-lobe phenotype, enhanceable by cas³⁹²¹

(Hitier et al., 2001)

drl^P1 has adult mushroom body beta-lobe phenotype, enhanceable by cas³⁹²¹

(Hitier et al., 2001)

drl^P1 has adult brain phenotype, enhanceable by cas³⁹²¹

(Hitier et al., 2001)

drl^P1 has ellipsoid body phenotype, enhanceable by cas³⁹²¹

(Hitier et al., 2001)

drl^P1 has mushroom body phenotype, enhanceable by cas³⁹²¹

(Hitier et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

In drl^P1, cas³⁹²¹ double mutants, fibres abnormally cross the midline above a flattened fan-shaped body in 55% of flies, the mushroom bodies β and β' lobes are fully fused in 33% of flies and the ellipsoid body is ventrally cleaved.

(Hitier et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

drl^P1 is rescued by drl^UAS.cCa/Scer\GAL4^7B

(Moreau-Fauvarque et al., 2002)

drl^P1 is rescued by drl^UAS.cCa/Scer\GAL4^7B

(Moreau-Fauvarque et al., 1998)

Not rescued by

drl^P1 is not rescued by drl^UAS.cCa/Scer\GAL4^7B

(Moreau-Fauvarque et al., 2002)

drl^P1 is not rescued by drl^tMa

(Moreau-Fauvarque et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

4763

w¹¹¹⁸; P{lacW}pigeon^P1, drl^P1/CyO, P{sevRas1.V12}FK1

Notes on Origin

Discoverer

Comments

P{lacW}pigeon^P1 is inserted 800 bp downstream of the pigeon transcription unit, perhaps in the 5'UTR of drl. In fact, the P{etau-lacZ} in drl^P3.765, is inserted 6 bp away from the pigeon^P1 allele. The P{lacW} insertion in the pigeon^P1 mutant could therefore be causing an additional drl phenotype.

(Tully, 1999.7.2)

Aspects of the expression pattern of P{lacW}pigeon^P1 correspond to that of drl.

(Bolwig et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

drl^P1

(Zhu et al., 2019)

linotte¹

(Moreau et al., 1998, Moreau et al., 1997)

lio¹

(Reynaud et al., 2015, van Swinderen, 2007, Tamura et al., 2003, Moreau-Fauvarque et al., 2002, Hitier et al., 2001, Hitier et al., 2000, Taillebourg and Dura, 2000, Taillebourg and Dura, 1999, Moreau-Fauvarque et al., 1998, Moreau et al., 1997, Dura et al., 1995, Dura et al., 1995, Dura et al., 1995)

Name Synonyms

Secondary FlyBase IDs

References (20)

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