FlyBase Allele Report: Dmel\Bx[hdpR590]

General Information

Symbol

Dmel\Bx^hdpR590

Species

D. melanogaster

Name

FlyBase ID

FBal0093475

Feature type

allele

Associated gene

Dmel\Bx

Associated Insertion(s)

P{GawB}Bx^hdpR590

Carried in Construct

Also Known As

hdp^R590

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Milan and Cohen, 1999, Milan et al., 1998)

Progenitor genotype

Bx^MS1096

(Milan et al., 1998)

Associated Insertion(s)

P{GawB}Bx^hdpR590

Cytology

Description

An internal deletion is found within the P-element.

(Zenvirt et al., 2008)

Imprecise excision of the P{GawB} element leaving Scer\GAL4 sequences unaffected.

(Milan and Cohen, 1999)

Imprecise excision of the P{GawB} element.

(Milan et al., 1998)

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical sensitive

(Tsai et al., 2004)

visible

(Milan et al., 2004)

visible | recessive

(Milan and Cohen, 2000, Milan and Cohen, 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant animals exhibit an increased sensitivity to cocaine.

(Tsai et al., 2004)

The dorsal compartment is reduced in size in mutant wing discs. Increased cell death is seen in mutant wing discs compared to wild type. The excess cell death is restricted to the dorsal wing pouch. Hemizygous Bx^hdpR590/Y flies show a reduction in size of the wing and abnormalities in vein formation. Homozygous clones do not show any abnormality in the notum or ventral wing surface. Clones survive poorly in the dorsal wing surface compared to the ventral surface. Dorsal clones induced in early-mid third instar are smaller and fewer in number than clones in the ventral compartment of the same wings. Clones induced in the mid second instar do not survive until the end of the third instar in the dorsal compartment.

(Milan and Cohen, 2000)

Flies have smaller than normal wings which are held in an abnormal position. The dorsal compartment is typically smaller than the ventral compartment, resulting in a slightly curled appearance. The pattern of wing veins is abnormal. Hemizygous wing discs have a reduced wing pouch.

(Milan and Cohen, 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Bx^hdpR590 has visible | adult stage phenotype, enhanceable by pnr[+]/pnr^VX6

(Zenvirt et al., 2008)

Bx^hdpR590 has visible | adult stage phenotype, enhanceable by pnr^MD237/pnr[+]

(Zenvirt et al., 2008)

Bx^hdpR590 has visible | recessive phenotype, enhanceable by Scer\GAL4^Bx-hdpR590/Ser^UAS.cSa

(Milan and Cohen, 2000)

Bx^hdpR590 has visible | recessive phenotype, enhanceable by fng[+]/fng¹³

(Milan and Cohen, 2000)

Suppressed by

Statement

Reference

Bx^hdpR590 has visible phenotype, suppressible by osa[+]/osa³⁰⁸

(Milan et al., 2004)

Bx^hdpR590 has visible | recessive phenotype, suppressible by fng^EP3082/Scer\GAL4^Bx-hdpR590

(Milan and Cohen, 2000)

Bx^hdpR590 has visible | recessive phenotype, suppressible by Scer\GAL4^Bx-hdpR590/Chi^ΔLID.UAS

(Milan and Cohen, 1999)

Bx^hdpR590 has visible | recessive phenotype, suppressible by Scer\GAL4^Bx-hdpR590/ap^ΔHD.UAS

(Milan and Cohen, 1999)

NOT Suppressor of

Statement

Reference

Bx^hdpR590 is a non-suppressor of visible | adult stage phenotype of Chi^E

(Zenvirt et al., 2008)

Other

Statement

Reference

Bx^hdpR590/Bx[+], ac¹ has visible | adult stage phenotype

(Zenvirt et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Bx^hdpR590 has anterior dorsocentral bristle phenotype, enhanceable by pnr[+]/pnr^VX6

(Zenvirt et al., 2008)

Bx^hdpR590 has anterior dorsocentral bristle phenotype, enhanceable by pnr^MD237/pnr[+]

(Zenvirt et al., 2008)

Bx^hdpR590 has wing phenotype, enhanceable by Scer\GAL4^Bx-hdpR590/Ser^UAS.cSa

(Milan and Cohen, 2000)

Bx^hdpR590 has wing phenotype, enhanceable by fng[+]/fng¹³

(Milan and Cohen, 2000)

Suppressed by

Statement

Reference

Bx^hdpR590 has wing margin phenotype, suppressible by osa[+]/osa³⁰⁸

(Milan et al., 2004)

Bx^hdpR590 has wing phenotype, suppressible by fng^EP3082/Scer\GAL4^Bx-hdpR590

(Milan and Cohen, 2000)

Bx^hdpR590 has wing disc phenotype, suppressible by Scer\GAL4^Bx-hdpR590/ap^ΔHD.UAS

(Milan and Cohen, 2000)

Bx^hdpR590 has wing phenotype, suppressible by Scer\GAL4^Bx-hdpR590/Chi^ΔLID.UAS

(Milan and Cohen, 1999)

Bx^hdpR590 has wing vein phenotype, suppressible by Scer\GAL4^Bx-hdpR590/Chi^ΔLID.UAS

(Milan and Cohen, 1999)

Bx^hdpR590 has wing phenotype, suppressible by Scer\GAL4^Bx-hdpR590/ap^ΔHD.UAS

(Milan and Cohen, 1999)

Bx^hdpR590 has wing vein phenotype, suppressible by Scer\GAL4^Bx-hdpR590/ap^ΔHD.UAS

(Milan and Cohen, 1999)

NOT Suppressor of

Statement

Reference

Bx^hdpR590 is a non-suppressor of anterior dorsocentral bristle phenotype of Chi^E

(Zenvirt et al., 2008)

Other

Statement

Reference

Bx^hdpR590/Bx[+], ac¹ has anterior dorsocentral bristle phenotype

(Zenvirt et al., 2008)

Bx^hdpR590, Chi^e5.5 has wing disc | dorsal phenotype

(Milan and Cohen, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of pnr^VX6 enhances the dorsocentral bristle loss seen in hemizygous Bx^hdpR590 mutant males. 90% of flies lack the anterior pair of bristles.

One copy of pnr^MD237 enhances the dorsocentral bristle loss seen in hemizygous Bx^hdpR590 mutant males. 90% of flies lack the anterior pair of bristles.

Flies carrying one copy of ac¹ and one copy of Bx^hdpR590 lack the anterior dorsocentral bristles. No phenotypes are observed in either heterozygote alone.

Flies carrying one copy of Chi^e5.5 and one copy of Bx^hdpR590 have a wild type number of dorsocentral bristles.

Bx^hdpR590 does not suppress the anterior dorsocentral bristle loss seen in Chi^E/+ mutant flies.

(Zenvirt et al., 2008)

The wing pouch is a normal size in Bx^hdpR590 wing discs expressing ap^{ΔHD.Scer\UAS} under the control of Scer\GAL4^Bx-hdpR590. The severity of the Bx^hdpR590/Y wing phenotype is enhanced by one copy of fng¹³. The severity of the Bx^hdpR590/Y wing phenotype is partially suppressed by expression of fng^EP3082 under the control of Scer\GAL4^Bx-hdpR590. The severity of the Bx^hdpR590/Y wing phenotype is enhanced by expression of Ser^Scer\UAS.cSa under the control of Scer\GAL4^Bx-hdpR590. Chi^e5.5 clones in the dorsal compartment of Bx^hdpR590 wing discs are much larger than their twin spots, whereas those in the ventral compartment are comparable in size to their twin spots.

(Milan and Cohen, 2000)

The Bx^hdpR590 phenotype can be suppressed by expression of Chi^{ΔLID.Scer\UAS} or ap^{ΔHD.Scer\UAS} under the control of Scer\GAL4^Bx-hdpR590.

(Milan and Cohen, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Bx^hdpR590

dLMO^GAL4

(Milan and Cohen, 2000)

dlmo^R590

(Zenvirt et al., 2008)

dlmo^hdpR590

(Zenvirt et al., 2008)

hdp^R590

(Milan et al., 2004, Tsai et al., 2004, Weihe et al., 2001, Milan and Cohen, 2000, Milan and Cohen, 1999)

Name Synonyms

Secondary FlyBase IDs

References (7)

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