FlyBase Allele Report: Dmel\N[FLN.ΔCdc10.UAS]

General Information

Symbol

Dmel\N^{FLN.ΔCdc10.UAS}

Species

D. melanogaster

Name

FlyBase ID

FBal0097212

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{UAS-N.FLNΔCdc10}

Also Known As

FLNΔCdc10, UAS-FLNΔcdc10

Key Links

Transgenic product class

dominant_negative_variant

(Zecchini et al., 1999)

inframe_deletion

(Zecchini et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(Zecchini et al., 1999)

inframe_deletion

(Zecchini et al., 1999)

Mutagen

in vitro construct

(Zecchini et al., 1999)

Progenitor genotype

N^ΔCDC10.hs

(Zecchini et al., 1999)

Carried in construct

P{UAS-N.FLNΔCdc10}

Cytology

Description

Coding region for N is deleted for the Cdc10/ANK repeats and the RAM23 domain, and is expressed from UAS regulatory sequences.

(Zecchini et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic epidermis, with Scer\GAL4^da.G32

(Zecchini et al., 1999)

embryonic epidermis | dorsal, with Scer\GAL4^pnr-MD237

(Zecchini et al., 1999)

embryonic hindgut, with Scer\GAL4^byn-Gal4

(Iwaki and Lengyel, 2002)

Detailed Description

Statement

Reference

Embryos expressing N^{FLN.ΔCdc10.Scer\UAS} under the control of Scer\GAL4^byn-Gal4 lack hindgut boundary cell rows and rings.

(Iwaki and Lengyel, 2002)

When expression is driven by Scer\GAL4^da.G32, embryos show a neurogenic phenotype. Residual dorsal epidermis shows severe crinkling and a hole, similar to the phenotype caused by N loss of function mutations. When expression is driven by Scer\GAL4^pnr-MD237 does not produce a neurogenic phenotype but causes dorsal crinkling similar to that seen in puc mutants.

(Zecchini et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

N^{FLN.ΔCdc10.UAS}/Scer\GAL4^Ser.PGF is a suppressor of wing disc phenotype of mib1³/mib1^EY09780

(Le Borgne et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

N^{FLN.ΔCdc10.UAS}/Scer\GAL4^da.G32 fails to rescue N^unspecified

(Zecchini et al., 1999)

Comments

Fails to rescue the neurogenic phenotype of N loss of function mutations, either dorsally or ventrally.

(Zecchini et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

N^{FLN.ΔCdc10.Scer\UAS}

N^{FLN.ΔCdc10.UAS}

N^FLN.ΔCdc10

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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