FlyBase Allele Report: Dmel\chico[unspecified]

General Information

Symbol

Dmel\chico^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0098251

Feature type

allele

Associated gene

Dmel\chico

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Martin-Pena et al., 2006)

abnormal size | larval stage

(Oldham et al., 2000)

partially lethal

(Teleman and Cohen, 2006)

visible

(Stocker et al., 2002)

Phenotype Manifest In

ellipsoid body

(Martin-Pena et al., 2006)

eye

(Stocker et al., 2002)

larval salivary gland & nucleus

(Oldham et al., 2000)

male germline stem cell (with Df(2L)J1)

(Ueishi et al., 2009)

polar primary spermatocyte (with Df(2L)J1)

(Ueishi et al., 2009)

primary spermatocyte (with Df(2L)J1)

(Ueishi et al., 2009)

synapse

(Martin-Pena et al., 2006)

Detailed Description

Statement

Reference

The average number of germline stem cells (GSCs) in the testis of chico^unspecified/Df(2L)J1 males within 24 hours of eclosion is similar to that seen in wild-type males at this time. However, the mutant males show an increased rate of reduction in GSC number with age compared to wild-type males, such that 14 days after eclosion, while the wild-type males maintain 90% of the GSC numbers of newly eclosed males, the mutant males maintain only 82% of the average GSC number of newly eclosed males.

chico^unspecified/Df(2L)J1 males that are within 24 hours of eclosion have a reduced number of stage S2b spermatocyte cysts in the testis compared to wild-type males. By 14 days after eclosion, stage S2b spermatocyte cysts are no longer detected in the mutant males.

The average diameter of stage S6 chico^unspecified/Df(2L)J1 spermatocytes is smaller than that of control spermatocytes at this stage.

(Ueishi et al., 2009)

In chico^unspecified mutant brains, the synaptic volume in the ellipsoid body is severely reduced.

(Martin-Pena et al., 2006)

The size of the nuclei in the chico endoreplicating salivary glands is smaller than wild-type.

(Oldham et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

chico^unspecified has decreased body size phenotype, enhanceable by Pi3K92E^unspecified

(Bohni et al., 1999)

Suppressed by

Statement

Reference

chico^unspecified has partially lethal phenotype, suppressible by mir-278^KO

(Teleman and Cohen, 2006)

Suppressor of

Statement

Reference

chico^unspecified is a suppressor | partially of short lived phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Imai et al., 2010)

NOT Suppressor of

Statement

Reference

chico^unspecified is a non-suppressor of visible phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Imai et al., 2010)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

chico^unspecified is a non-suppressor of wing phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Imai et al., 2010)

chico^unspecified is a non-suppressor of ommatidium phenotype of Akt^{UAS.Tag:HA,Tag:MyrPalm(Lck)}, Scer\GAL4^GMR.PF

(Stocker et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

chico^unspecified significantly suppresses the short lifespan phenotype of flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW, but fails to suppress the abnormal wing posture of these flies.

(Imai et al., 2010)

Expression of a catalytically inactive form of Pi3K92E in homozygous wing discs leads to a further reduction in size by 48%.

(Bohni et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

chico^unspecified is rescued by chico^Drkmut

(Oldham et al., 2002)

chico^unspecified is rescued by chico^+t8

(Oldham et al., 2002)