FlyBase Allele Report: Dmel\Diap1[UAS.cLa]

General Information

Symbol

Dmel\Diap1^UAS.cLa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Lisi

FlyBase ID

FBal0103507

Feature type

allele

Associated gene

Dmel\Diap1

Associated Insertion(s)

Carried in Construct

P{UAS-Diap1.L}

Also Known As

UAS-diap1, UAS-th

Key Links

Transgenic product class

wild_type

(Lisi et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Lisi et al., 2000)

Mutagen

in vitro construct

(Lisi et al., 2000)

Progenitor genotype

Carried in construct

P{UAS-Diap1.L}

Cytology

Description

The Diap1 coding region is expressed under the control of UASt regulatory sequences.

(Lisi et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Diap1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82.UAS

(Ghosh and Feany, 2004)

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Ghosh and Feany, 2004)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of th^Scer\UAS.cLa under the control of Scer\GAL4^ey.PH in wild-type eyes does not affect eye size.

(Singh et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Diap1^UAS.cLa/Scer\GAL4^ey.PH is a suppressor of increased cell death | dominant | larval stage phenotype of L²

(Singh et al., 2006)

Diap1^UAS.cLa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Diap1^UAS.cLa/Scer\GAL4^GMR.PF is a suppressor of abnormal cell death phenotype of hid^GMR.PG

(Lisi et al., 2000)

Diap1^UAS.cLa/Scer\GAL4^GMR.PF is a suppressor of abnormal cell death phenotype of grim^GMR.PC

(Lisi et al., 2000)

Diap1^UAS.cLa/Scer\GAL4^GMR.PF is a suppressor of abnormal cell death phenotype of rpr^GMR.PW

(Lisi et al., 2000)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Diap1^UAS.cLa, Scer\GAL4^GMR.PF is a non-enhancer of retina phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Ghosh and Feany, 2004)

Suppressor of

Statement

Reference

Diap1^UAS.cLa/Scer\GAL4^ey.PH is a suppressor of eye disc | ventral phenotype of L²

(Singh et al., 2006)

Diap1^UAS.cLa/Scer\GAL4^ey.PH is a suppressor of eye | ventral phenotype of L²

(Singh et al., 2006)

Diap1^UAS.cLa/Scer\GAL4^vg.int2.1 is a suppressor of wing | conditional phenotype of vg^null

(Delanoue et al., 2004)

Diap1^UAS.cLa, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Diap1^UAS.cLa, Scer\GAL4^30Y is a suppressor of adult brain phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Diap1^UAS.cLa, Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Diap1^UAS.cLa, Scer\GAL4^ChAT.7.4 is a suppressor of adult brain phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^ChAT.7.4

(Ghosh and Feany, 2004)

Diap1^UAS.cLa, Scer\GAL4^GMR.PF is a suppressor of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Diap1^UAS.cLa/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of hid^GMR.PG

(Lisi et al., 2000)

Diap1^UAS.cLa/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of grim^GMR.PC

(Lisi et al., 2000)

Diap1^UAS.cLa/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of rpr^GMR.PW

(Lisi et al., 2000)

NOT Suppressor of

Statement

Reference

Diap1^UAS.cLa, Scer\GAL4^GMR.PF is a non-suppressor of retina phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Ghosh and Feany, 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of th^Scer\UAS.cLa under the control of Scer\GAL4^ey.PH results in a partial suppression of the L²/+ phenotype. 27% of rescued flies have eyes that are more than three-quarters of the wild-type size and a range of intermediate and weaker rescues are observable in the other 73%.

(Singh et al., 2006)

Expression of th^Scer\UAS.cLa at the dorsal/ventral wing disc boundary under the control of Scer\GAL4^vg.int2.1 rescues the strong wing margin phenotype observed in vg^null/+ flies grown on aminopterin (0.5mg/kg).

(Delanoue et al., 2004)

Suppression of rpr^GMR.PW by th^{V85M.Scer\UAS}, when driven by Scer\GAL4^GMR.PF is complete and stronger than that caused by th^Scer\UAS.cLa. Suppression of grim^GMR.PC by th^{V85M.Scer\UAS} (or th^Scer\UAS.cLa), when driven by Scer\GAL4^GMR.PF is also complete. Suppression of W^GMR.PG by th^Scer\UAS.cLa, when driven by Scer\GAL4^GMR.PF is stronger than that caused by th^{V85M.Scer\UAS}, though in both cases the suppression is incomplete.

(Lisi et al., 2000)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by co-expression of th^Scer\UAS.cLa.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Diap1^Scer\UAS.cLa

Diap1^UAS.cLa

th^Scer\UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Lisi

(Lisi et al., 2000)

Secondary FlyBase IDs

References (7)

Report Sections

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