FlyBase Allele Report: Zzzz\CAG[127Q.UAS.Tag:HA]

General Information

Symbol

Zzzz\CAG^{127Q.UAS.Tag:HA}

Species

a. artificial

Name

FlyBase ID

FBal0104696

Feature type

allele

Associated gene

Zzzz\CAG

Associated Insertion(s)

Carried in Construct

P{UAS-Zzzz\CAG.127Q}

Also Known As

UAS-127Q, UAS-Q127, UAS-poly127Q, 127Q

Transgenic product class

trinucleotide_repeat_expansion

(Kazemi-Esfarjani and Benzer, 2000)

Mutagen

Nature of the Allele

Transgenic product class

trinucleotide_repeat_expansion

(Kazemi-Esfarjani and Benzer, 2000)

Mutagen

in vitro construct - regulatory fusion

(Kazemi-Esfarjani and Benzer, 2000)

in vitro construct - coding region fusion

(Kazemi-Esfarjani and Benzer, 2000)

Progenitor genotype

Carried in construct

P{UAS-Zzzz\CAG.127Q}

Cytology

Description

UAS regulatory sequences drive expression of a 127 amino acid polyglutamine tract (derived from the pros gene) tagged with Tag:HA. The polyglutamine tract is flanked by 8 amino acids (MGGPPSTP) on the N-terminal side and 13 amino acids on the C-terminal side (TSRTYPYDVPDYA).

(Kazemi-Esfarjani and Benzer, 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Zzzz\CAG

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Huntington's disease

CEA

(Yadav and Tapadia, 2016)

model of neurodegenerative disease

CEA

(Dubey et al., 2024, Swinter et al., 2023, Dubey and Tapadia, 2018, Singh et al., 2017, Krench et al., 2016, Nelson et al., 2016, Yadav and Tapadia, 2013, Wang et al., 2012, Mallik and Lakhotia, 2009, Murata et al., 2008, Ghosh and Feany, 2004, Gunawardena et al., 2003, Taylor et al., 2003, Kazemi-Esfarjani and Benzer, 2002, Kazemi-Esfarjani and Benzer, 2000)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of neurodegenerative disease

is ameliorated by DnaJ-1^EU3500

(Kazemi-Esfarjani and Benzer, 2000)

is ameliorated by DnaJ-1^UAS.cKa

(Ghosh and Feany, 2004, Kazemi-Esfarjani and Benzer, 2000)

is ameliorated by Tpr2^UAS.cKa

(Kazemi-Esfarjani and Benzer, 2000)

is ameliorated by Tpr2^EU3220

(Kazemi-Esfarjani and Benzer, 2000)

is exacerbated by nej^P

(Taylor et al., 2003)

is ameliorated by nej^EP1149

(Taylor et al., 2003)

is ameliorated by nej^EP1179

(Taylor et al., 2003)

is exacerbated by Atx2^EP3145

(Ghosh and Feany, 2004)

is exacerbated by CG7231^EP2510

(Ghosh and Feany, 2004)

is exacerbated by Atx2^UAS.cSa

(Ghosh and Feany, 2004)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Ghosh and Feany, 2004)

is exacerbated by Hsc70-4^K71S.UAS

(Ghosh and Feany, 2004)

is ameliorated by Mlf^EU2490

(Kazemi-Esfarjani and Benzer, 2002)

is exacerbated by Khc⁹

(Gunawardena et al., 2003)

is ameliorated by Hsc70-4^UAS.cEa

(Gunawardena et al., 2003)

is exacerbated by lncRNA:Hsrω^EP3037

(Mallik and Lakhotia, 2009, Sengupta and Lakhotia, 2006)

is exacerbated by lncRNA:Hsrω^EP93D

(Mallik and Lakhotia, 2009, Sengupta and Lakhotia, 2006)

is ameliorated by lncRNA:Hsrω^RNAi.Sym.UAS

(Mallik and Lakhotia, 2009)

is exacerbated by Mdr50^HMS01448

(Yadav and Tapadia, 2013)

is exacerbated by Mdr49^HMS00400

(Yadav and Tapadia, 2013)

is exacerbated by Mdr65^HMS01449

(Yadav and Tapadia, 2013)

is ameliorated by Zw^UAS.cLa

(Wang et al., 2012)

is ameliorated by Rpi^RNAi.Sym.UAS

(Wang et al., 2012)

is ameliorated by AttA^TRiP.cUa

(Dubey and Tapadia, 2018)

is ameliorated by CycE^UAS.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Dif^TRiP.cUa

(Dubey and Tapadia, 2018)

is ameliorated by DptA^TRiP.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Dro^RNAi.UAS

(Dubey and Tapadia, 2018)

is ameliorated by Drs^TRiP.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Rel^TRiP.cUa

(Dubey and Tapadia, 2018)

is ameliorated by mir-ban^C.UAS.EGFP

(Dubey and Tapadia, 2018)

is ameliorated by yki^UAS.cHa

(Dubey and Tapadia, 2018)

is exacerbated by yki^RNAi.UAS.cUa

(Dubey and Tapadia, 2018)

is ameliorated by Drp1^KG03815

(Swinter et al., 2023)

is ameliorated by RanGAP^EY21763

(Dubey et al., 2024)

is exacerbated by RanGAP^JF03244

(Dubey et al., 2024)

is exacerbated by lncRNA:Hsrω⁰⁵²⁴¹

(Sengupta and Lakhotia, 2006)

is exacerbated by PolE1^pl10R

(Sengupta and Lakhotia, 2006)

is NOT ameliorated by Hsap\ATXN1L^UAS.Tag:FLAG

(Mizutani et al., 2005)

is ameliorated by DnaJ-1^UAS.cKb

(Kuo et al., 2013)

is exacerbated by Hsp110^HMS01080

(Kuo et al., 2013)

is ameliorated by Hsap\DNAJB1^UAS.cKa

(Kuo et al., 2013)

is ameliorated by Hsp60D^RNAi.Sym.UAS

(Arya et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | P-stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

abnormal eye color, with Scer\GAL4^GMR.PF

(Wang et al., 2012, Mallik and Lakhotia, 2009, Kazemi-Esfarjani and Benzer, 2000)

abnormal locomotor behavior | larval stage, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

abnormal locomotor behavior | larval stage, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Akanksha et al., 2008, Sengupta and Lakhotia, 2006)

abnormal phototaxis, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

abnormal phototaxis, with Scer\GAL4^GMR.PU

(Arya et al., 2010)

abnormal visual behavior, with Scer\GAL4^GMR.PF

(Taylor et al., 2003)

increased cell death, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

increased cell death, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

increased cell death | larval stage, with Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

lethal | heat sensitive, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

lethal | heat sensitive, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

lethal - all die before end of larval stage, with Scer\GAL4^Appl.G1a

(Kazemi-Esfarjani and Benzer, 2002)

lethal - all die before end of larval stage, with Scer\GAL4^elav-C155

(Mallik and Lakhotia, 2009)

lethal - all die before end of P-stage, with Scer\GAL4^elav.PU

(Arya et al., 2010)

lethal - all die during P-stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

lethal - all die during P-stage, with Scer\GAL4^c649

(Yadav and Tapadia, 2016)

partially lethal, with Scer\GAL4^elav.PU

(Lee et al., 2012)

some die during embryonic stage, with Scer\GAL4^elav.PU

(Lee et al., 2012)

some die during larval stage, with Scer\GAL4^Appl.G1a

(Kazemi-Esfarjani and Benzer, 2002)

some die during P-stage, with Scer\GAL4^elav.PU

(Arya et al., 2010)

some die during third instar larval stage, with Scer\GAL4^elav-C155

(Mallik and Lakhotia, 2009)

viable, with Scer\GAL4^GMR.PF

(Ray and Lakhotia, 2019)

viable, with Scer\GAL4^Uro.PT

(Yadav and Tapadia, 2016)

visible, with Scer\GAL4^ey.PB

(Berger et al., 2005)

visible, with Scer\GAL4^GMR.PF

(Lee et al., 2012, Wang et al., 2012, Lee et al., 2011, Al-Ramahi et al., 2006, Fayazi et al., 2006, Kazemi-Esfarjani and Benzer, 2000)

visible, with Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013, Arya et al., 2010)

visible, with Scer\GAL4^GMR.PY

(Takeyama et al., 2002)

visible | adult stage, with Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Phenotype Manifest In

adult abdomen | P-stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

adult cuticle | pharate adult stage, with Scer\GAL4^c649

(Yadav and Tapadia, 2016)

adult head | P-stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

adult main segment of Malpighian tubule | pharate adult stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

adult Malpighian tubule principal cell | pharate adult stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

adult thorax | P-stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

axon | larval stage, with Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

embryonic/larval Malpighian tubule | third instar larval stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

embryonic/larval Malpighian tubule Type I cell | third instar larval stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

embryonic/larval optic stalk, with Scer\GAL4^GMR.PF

(Sengupta and Lakhotia, 2006)

eye, with Scer\GAL4^ey.PB

(Berger et al., 2005)

eye, with Scer\GAL4^GMR.PF

(Lee et al., 2012, Wang et al., 2012, Lee et al., 2011, Park et al., 2011, Mallik and Lakhotia, 2010, Mallik and Lakhotia, 2009, Akanksha et al., 2008, Al-Ramahi et al., 2006, Fayazi et al., 2006, Mizutani et al., 2005, Tsuda et al., 2005, Taylor et al., 2003, Kazemi-Esfarjani and Benzer, 2002, Kazemi-Esfarjani and Benzer, 2000)

eye, with Scer\GAL4^GMR.PU

(Kuo et al., 2013, Yadav and Tapadia, 2013)

eye, with Scer\GAL4^GMR.PY

(Takeyama et al., 2002)

eye photoreceptor cell, with Scer\GAL4^GMR.PU

(Arya et al., 2010)

haltere | pharate adult stage, with Scer\GAL4^c649

(Yadav and Tapadia, 2016)

inclusion body | increased number, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

larval segmental nerve, with Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

leg | pharate adult stage, with Scer\GAL4^c649

(Yadav and Tapadia, 2016)

Malpighian tubule | P-stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

mitochondrion | larval stage, with Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

neuron, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

neuron, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

nucleus | pharate adult stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

nucleus | third instar larval stage, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

ommatidium, with Scer\GAL4^GMR.PF

(Park et al., 2011, Al-Ramahi et al., 2006, Sengupta and Lakhotia, 2006)

ommatidium, with Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013, Arya et al., 2010)

ommatidium, with Scer\GAL4^GMR.PY

(Takeyama et al., 2002)

photoreceptor, with Scer\GAL4^GMR.PU

(Kuo et al., 2013)

pigment cell, with Scer\GAL4^GMR.PF

(Kazemi-Esfarjani and Benzer, 2000)

pigment granule, with Scer\GAL4^GMR.PF

(Sengupta and Lakhotia, 2006)

pupal tracheal section, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

puparium cuticle, with Scer\GAL4^c42

(Yadav and Tapadia, 2016)

retina, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009, Al-Ramahi et al., 2006, Ghosh and Feany, 2004, Kazemi-Esfarjani and Benzer, 2000)

rhabdomere, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

wing | heat sensitive, with Scer\GAL4^cv-c-C5

(Tsuda et al., 2005)

wing | pharate adult stage, with Scer\GAL4^c649

(Yadav and Tapadia, 2016)

Detailed Description

Statement

Reference

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^c42 results in lethality in P-stage. Progeny appear grossly normal in both morphology and behavior until pupariation. Pupae are smaller in size as compared to wild type and display unevenly pigmented pupal cases, defective arrangement and morphology of trachea; begin to show signs of desiccation and shrinkage by 24-72h APF; display defects in epithelial morphogenesis, including dorsal closure and head eversion defects, leading to micro- or cryptocephaly; rudimentary or absent thoraces, and loss of 1-2 abdominal segments; defects in Malpighian tubules (MTs) including ectopic white concretions at 96h APF, loss of distinction between different segments, and variable reduction in lumen size or lumen loss of the main MT segment. MT function is severely impaired in both pupal and 3rd instar larval stages. Principal cells of the MT display enlarged nuclei with loose or fragmented chromatin in both third instar larvae and at 96h APF.

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^c649 results in lethality in P-stage. A small fraction are able to develop until just before eclosion, but are unable to open the pupal case and subsequently die; these flies display abnormal haltere position, abnormally large legs, rudimentary wings that appear to adhere to the abdomen, and excessive cuticle pigmentation. With assisted eclosion, these flies survive only up to 2-3 hrs.

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Uro.PT does not result in lethality.

(Yadav and Tapadia, 2016)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU results in flies with severely abnormal eyes with an absence of pigmentation. Complete photoreceptor loss is seen in the retina.

(Kuo et al., 2013)

Animals expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU show variable eye degeneration with the phenotypes including loss of pigmentation, formation of necrotic patches and collapsed eyes. Loss of ommatidial clusters and ommatidial fusions are seen.

Polyglutamine inclusion bodies and disruption of the rhabdomere arrangement is seen in the eye discs of third instar larvae expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU. The axonal projections of photoreceptor axons into the optic lobe are disrupted. The organisation of actin filaments in the eye disc is disrupted.

(Yadav and Tapadia, 2013)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU results in a significant (35%) reduction in hatching rate of embryos compared to controls and most embryos are deformed.

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in eye degeneration.

(Lee et al., 2012)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in rough eyes which show loss of pigmentation.

(Wang et al., 2012)

The eye-degeneration phenotype caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is not mitigated by feeding flies with linoleic acid and linolenic acid.

(Lee et al., 2011)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} in the developing eye under the control of Scer\GAL4^GMR.PF induces clear defects in the eye, with defective ommatidia seen in 18% of cases.

(Park et al., 2011)

Scer\GAL4^GMR.PU-driven expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} induces severe eye degeneration and results in glazed, de-pigmented and collapsed eyes. Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} expressing pupal eyes show severe disorganisation and in many cases a complete loss of photoreceptor cells is also seen.

Unlike wild-type controls, flies overexpressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU do not show any significant phototaxis.

Pan-neuronal overexpression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^elav.PU results in 100% lethality at pupal stage.

(Arya et al., 2010)

Scer\GAL4^GMR.PF-mediated expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} causes eye degeneration.

Scer\GAL4^GMR.PF-mediated expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} produces poly(Q) inclusion bodies in eye disc cells.

(Mallik and Lakhotia, 2010)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} using Scer\GAL4^GMR.PF results in collapsed eyes with loss of pigmentation and disruption of the regular array of ommatidia. Retinal structure is disrupted, photoreceptor neurons are lost, and large vacuoles appear in the tissue.

2-day old flies expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} using Scer\GAL4^GMR.PF fail to detect light.

(Mallik and Lakhotia, 2009)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in a glassy external eye phenotype with severe ommatidial disorganisation. The flies show severe retinal degeneration with abundant vacuolisation.

(Al-Ramahi et al., 2006)

Retinas appear disorganised in 5 week old flies expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ninaE.PD.

(Fayazi et al., 2006)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, under the control of Scer\GAL4^C5, does not result in wing abnormalities.

(Lam et al., 2006)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} in the developing eye disc, under the control of Scer\GAL4^GMR.PF results in a loss of pigmentation and disruption of the regular ordered arrays of ommatidia in adult eyes without affecting the eye size. Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} in the developing eye disc, under the control of Scer\GAL4^GMR.PF leads to disarrayed axonal projections in the optic stalk.

(Sengupta and Lakhotia, 2006)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ey.PB results in a rough eye phenotype which can be partially rescued by AR-A014418.

(Berger et al., 2005)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, under the control of Scer\GAL4^GMR.PF results in a severe eye phenotype, however, while Scer\GAL4^GMR.PF drives expression in the wing, no wing vein phenotype is observed. Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, under the control of Scer\GAL4^C5 in the wing pouch does not cause significant vein abnormalities, although it does induce a mild wing atrophy at 29^oC. Overexpression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, under the control of Scer\GAL4^C96 in the wing margin does not cause patterning defects.

(Tsuda et al., 2005)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in a retinal degeneration phenotype.

(Ghosh and Feany, 2004)

Animals expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^179Y or Scer\GAL4^Appl.G1a exhibit a severe sluggish larval movement phenotype. A large increase in neuronal apoptosis is seen. When Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is overexpressed at 29^oC larvae do not survive to adulthood but die at second or third instar larval stage.

(Gunawardena et al., 2003)

Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PF causes progressive eye degeneration. Mutants are effectively blind, exhibiting defective phototaxis behaviour.

(Taylor et al., 2003)

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} in the developing eye under the control of Scer\GAL4^GMR.PF results in severely collapsed eyes that lack pigmentation. An accumulation of poly(Q) clumps is detected in mutant eyes.

Expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} in the developing nervous system under the control of Scer\GAL4^Appl.G1a results in pre-adult lethality.

(Kazemi-Esfarjani and Benzer, 2002)

Transgenic flies carrying Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and Scer\GAL4^GMR.PY have a rough eye phenotype.

(Takeyama et al., 2002)

Adults expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF have severely abnormal eyes and lack pigmentation. The retina is badly deformed.

(Kazemi-Esfarjani and Benzer, 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, enhanceable by Hsp110^HMS01080, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by Mdr49^HMS00400, Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by Mdr50^HMS01448, Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by Mdr65^HMS01449, Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by Cul1^KK100827, Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by Cul1^GD9650, Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by SkpA^GD16179/Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by XNP^EP635/Scer\GAL4^GMR.PF

(Lee et al., 2012)

Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by Uba2^C175S.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by Prosβ6^1.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by Diap1⁵/th[+]

(Arya et al., 2010)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, enhanceable by Uba2^C175S.UAS/Scer\GAL4^GMR.PU

(Arya et al., 2010)

Df(3R)Hrb87F/+, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has partially lethal - majority die | pupal stage phenotype, enhanceable by lncRNA:Hsrω^EP3037, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^{F2161A.UAS.Tag:V5} has partially lethal - majority die | pupal stage phenotype, enhanceable by lncRNA:Hsrω^EP3037/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal eye color phenotype, enhanceable by lncRNA:Hsrω^EP3037/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal eye color phenotype, enhanceable by Scer\GAL4^GMR.PF/lncRNA:Hsrω^EP93D

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal neuroanatomy phenotype, enhanceable by lncRNA:Hsrω⁰⁵²⁴¹/Hsromega[+]

(Akanksha et al., 2008, Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal neuroanatomy phenotype, enhanceable by Df(3R)Hrb87F/+

(Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal neuroanatomy phenotype, enhanceable by lncRNA:Hsrω⁰⁵²⁴¹/lncRNA:Hsrω⁰⁵²⁴¹

(Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal neuroanatomy phenotype, enhanceable by l(3)pl10[+]/PolE1^pl10R

(Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal neuroanatomy phenotype, enhanceable by lncRNA:Hsrω^EP3037/Scer\GAL4^GMR.PF

(Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^GMR.PF/lncRNA:Hsrω^EP93D

(Sengupta and Lakhotia, 2006)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-enhanceable by Df(3R)Hsp70B/Df(3R)Hsp70A

(Kuo et al., 2013)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, non-enhanceable by Rpi^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Df(3R)Hrb87F/+, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has partially lethal - majority die | pupal stage phenotype, non-enhanceable by lncRNA:Hsrω^EP93D, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^{F2161A.UAS.Tag:V5} has partially lethal - majority die | pupal stage phenotype, non-enhanceable by Scer\GAL4^GMR.PF/lncRNA:Hsrω^EP93D

(Mallik and Lakhotia, 2010)

Suppressed by

Statement

Reference

Hsap\DNAJB1^UAS.cKa, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, suppressible | partially by Hsap\HSPA4L^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, suppressible | partially by DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Df(3R)Hsp70A, Df(3R)Hsp70B, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, suppressible | partially by DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, suppressible by Hsp83^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, suppressible | partially by Hsap\DNAJB1^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.PF

(Wang et al., 2012, Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^elav.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has partially lethal phenotype, suppressible by XNP[+]/XNP^C1

(Lee et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, suppressible by Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal eye color phenotype, suppressible by Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal eye color phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, suppressible | partially by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Scer\GAL4^elav.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has lethal | P-stage phenotype, suppressible | partially by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^elav.PU

(Arya et al., 2010)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal phototaxis phenotype, suppressible | partially by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Df(3R)Hrb87F/+, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has partially lethal - majority die | pupal stage phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^{F2161A.UAS.Tag:V5} has partially lethal - majority die | pupal stage phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^RNAi.UAS.cKa has lethal | pharate adult stage phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal eye color phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal phototaxis phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, lncRNA:Hsrω^EP3037 has abnormal eye color phenotype, suppressible | partially by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, lncRNA:Hsrω^EP93D has abnormal eye color phenotype, suppressible | partially by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Scer\GAL4^elav-C155, Zzzz\CAG^{127Q.UAS.Tag:HA} has lethal | late third instar larval stage phenotype, suppressible by Scer\GAL4^elav-C155/lncRNA:Hsrω^RNAi.Sym.UAS

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, suppressible by Hsap\STUB1^UAS.cAa, Scer\GAL4^GMR.PF

(Al-Ramahi et al., 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, suppressible by mrj^EU639/Scer\GAL4^GMR.PF

(Fayazi et al., 2006)

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has increased cell death phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, suppressible by DnaJ-1^EU3500

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal eye color phenotype, suppressible by DnaJ-1^EU3500

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, suppressible by Tpr2^EU3220

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has abnormal eye color phenotype, suppressible by Tpr2^EU3220

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, suppressible by Tpr2^UAS.cKa/Scer\GAL4^GMR.PF

(Kazemi-Esfarjani and Benzer, 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsp60A^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsp68^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-1^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-2^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-5^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsp83^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsp60A^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsp68^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-1^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-2^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsc70-5^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsp110^K68S.UAS, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsp110^KD.UAS, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA}, mrj^UAS.Tag:FLAG has visible | adult stage phenotype, non-suppressible by Hsp110^KD.UAS, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsp110^HMS01080/DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsap\DNAJB4^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsap\HSPH1^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible | adult stage phenotype, non-suppressible by Hsap\HSPA4L^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Diap1⁵/th[+], Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has visible phenotype, non-suppressible by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Diap1^RNAi.UAS, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has lethal phenotype, non-suppressible by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Other

Statement

Reference

Cul1^GD9650, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has lethal phenotype

(Bhutani et al., 2012)

Hsap\CUL1^UAS.cBa, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has lethal phenotype

(Bhutani et al., 2012)

Scer\GAL4^GMR.PU, SkpA^GD16179, Zzzz\CAG^{127Q.UAS.Tag:HA} has lethal phenotype

(Bhutani et al., 2012)

Cul1^KK100827, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has lethal phenotype

(Bhutani et al., 2012)

Diap1^RNAi.UAS, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has lethal phenotype

(Arya et al., 2010)

Df(3R)Hrb87F/+, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has partially lethal - majority die | pupal stage phenotype

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^{F2161A.UAS.Tag:V5} has partially lethal - majority die | pupal stage phenotype

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^RNAi.UAS.cKa has lethal | pharate adult stage phenotype

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, lncRNA:Hsrω^EP3037, nej^RNAi.UAS.cKa has lethal | pharate adult stage phenotype

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, lncRNA:Hsrω^EP93D, nej^RNAi.UAS.cKa has lethal | pharate adult stage phenotype

(Mallik and Lakhotia, 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Hsp110^HMS01080, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, enhanceable by Hsp110^HMS01080, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Mdr49^HMS00400, Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has rhabdomere phenotype, enhanceable by Mdr49^HMS00400, Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Mdr50^HMS01448, Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has rhabdomere phenotype, enhanceable by Mdr50^HMS01448, Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Mdr65^HMS01449, Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has rhabdomere phenotype, enhanceable by Mdr65^HMS01449, Scer\GAL4^GMR.PU

(Yadav and Tapadia, 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Cul1^KK100827, Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Cul1^GD9650, Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by SkpA^GD16179/Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by XNP^EP635/Scer\GAL4^GMR.PF

(Lee et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has ommatidium phenotype, enhanceable by Mmus\Prnp^{P101L.UAS.Tag:3F4}, Scer\GAL4^GMR.PF

(Park et al., 2011)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Mmus\Prnp^{P101L.UAS.Tag:3F4}, Scer\GAL4^GMR.PF

(Park et al., 2011)

Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has ommatidium phenotype, enhanceable by Uba2^C175S.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has ommatidium phenotype, enhanceable by Prosβ6^1.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has ommatidium phenotype, enhanceable by Diap1⁵/th[+]

(Arya et al., 2010)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has ommatidium phenotype, enhanceable by Uba2^C175S.UAS/Scer\GAL4^GMR.PU

(Arya et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by esg^EU143/Scer\GAL4^GMR.PF

(Kazemi-Esfarjani, 2010.6.21)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Scer\GAL4^GMR.PF/rgr^EU4350

(Kazemi-Esfarjani, 2010.6.21)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by nej^{F2161A.UAS.Tag:V5}/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by nej^RNAi.UAS.cKa/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Prosβ6^1.B.UAS/Prosβ2^1.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has inclusion body | increased number phenotype, enhanceable by Prosβ6^1.B.UAS/Prosβ2^1.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Df(3R)Hrb87F/+, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by lncRNA:Hsrω^EP3037, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Df(3R)Hrb87F/+, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by lncRNA:Hsrω^EP93D, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^{F2161A.UAS.Tag:V5} has eye phenotype, enhanceable by lncRNA:Hsrω^EP3037/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^{F2161A.UAS.Tag:V5} has eye phenotype, enhanceable by Scer\GAL4^GMR.PF/lncRNA:Hsrω^EP93D

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Df(3R)Hrb87F/+

(Mallik and Lakhotia, 2010, Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by lncRNA:Hsrω^EP3037/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009, Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Scer\GAL4^GMR.PF/lncRNA:Hsrω^EP93D

(Mallik and Lakhotia, 2009, Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by lncRNA:Hsrω⁰⁵²⁴¹/Hsromega[+]

(Akanksha et al., 2008, Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by hoip^GS7164/Scer\GAL4^GMR.PF

(Murata et al., 2008)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by nop5^UAS.cMa/Scer\GAL4^GMR.PF

(Murata et al., 2008)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by Nop56^UAS.cMa, Scer\GAL4^GMR.PF

(Murata et al., 2008)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has embryonic/larval optic stalk phenotype, enhanceable by lncRNA:Hsrω⁰⁵²⁴¹/lncRNA:Hsrω⁰⁵²⁴¹

(Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by l(3)pl10[+]/PolE1^pl10R

(Sengupta and Lakhotia, 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, enhanceable by Atx2^EP3145, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, enhanceable by nej^P

(Taylor et al., 2003)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has mitochondrion | larval stage phenotype, non-enhanceable by Drp1^UAS.cDa, Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has larval segmental nerve phenotype, non-enhanceable by Drp1^UAS.cDa, Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-enhanceable by Df(3R)Hsp70B/Df(3R)Hsp70A

(Kuo et al., 2013)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-enhanceable by Rpi^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-enhanceable by Sirt1^EP2300/Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-enhanceable by tara^EP3463/Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-enhanceable by Scer\GAL4^GMR.PF/pum^EP3461

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-enhanceable by BacA\p35^UAS.cUa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-enhanceable by Diap1^UAS.cLa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Suppressed by

Statement

Reference

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has mitochondrion | larval stage phenotype, suppressible by Drp1^KG03815/Drp1[+]

(Swinter et al., 2023)

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has larval segmental nerve phenotype, suppressible by Drp1^KG03815/Drp1[+]

(Swinter et al., 2023)

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has mitochondrion | larval stage phenotype, suppressible by Hsap\MFN2^UAS.cDa, Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has larval segmental nerve phenotype, suppressible by Hsap\MFN2^UAS.cDa, Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible | partially by DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Df(3R)Hsp70A, Df(3R)Hsp70B, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible | partially by DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by Hsp83^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, suppressible by Hsp83^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible | partially by Hsap\DNAJB1^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Hsap\DNAJB1^UAS.cKa, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible | partially by Hsap\HSPA4L^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.PF

(Wang et al., 2012, Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by Rpi^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2012)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has ommatidium phenotype, suppressible | partially by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by lncRNA:CR43334^EU119/Scer\GAL4^GMR.PF

(Kazemi-Esfarjani, 2010.6.21)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by Ddr^EU173, Scer\GAL4^GMR.PF

(Kazemi-Esfarjani, 2010.6.21)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by lncRNA:CR43334^EU820/Scer\GAL4^GMR.PF

(Kazemi-Esfarjani, 2010.6.21)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by Cam^EU1250, Scer\GAL4^GMR.PF

(Kazemi-Esfarjani, 2010.6.21)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by scat^EU2290/Scer\GAL4^GMR.PF

(Kazemi-Esfarjani, 2010.6.21)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by wech^EU2335/Scer\GAL4^GMR.PF

(Kazemi-Esfarjani, 2010.6.21)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by osi^EU4801/Scer\GAL4^GMR.PF

(Kazemi-Esfarjani, 2010.6.21)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010, Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has inclusion body | increased number phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Df(3R)Hrb87F/+, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^{F2161A.UAS.Tag:V5} has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, nej^RNAi.UAS.cKa has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has rhabdomere phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, lncRNA:Hsrω^EP3037 has eye phenotype, suppressible | partially by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}, lncRNA:Hsrω^EP93D has eye phenotype, suppressible | partially by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by mrj^EU639/Scer\GAL4^GMR.PF

(Fayazi et al., 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has neuron phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by nej^EP1149/Scer\GAL4^GMR.PF

(Taylor et al., 2003)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by Scer\GAL4^GMR.PF/nej^EP1179

(Taylor et al., 2003)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by Mlf^UAS.cKa, Scer\GAL4^GMR.PF

(Kazemi-Esfarjani and Benzer, 2002)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by Mlf^EU2490, Scer\GAL4^GMR.PF

(Kazemi-Esfarjani and Benzer, 2002)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by DnaJ-1^EU3500

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has pigment cell phenotype, suppressible by DnaJ-1^EU3500

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, suppressible by DnaJ-1^EU3500

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by Tpr2^EU3220

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has pigment cell phenotype, suppressible by Tpr2^EU3220

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, suppressible by Tpr2^EU3220

(Kazemi-Esfarjani and Benzer, 2000)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, suppressible by Tpr2^UAS.cKa/Scer\GAL4^GMR.PF

(Kazemi-Esfarjani and Benzer, 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has mitochondrion | larval stage phenotype, non-suppressible by Drp1^UAS.cDa, Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has larval segmental nerve phenotype, non-suppressible by Drp1^UAS.cDa, Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-5^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsp83^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsp83^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsp60A^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsp68^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-1^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-2^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-5^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsp60A^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsp68^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsc70-1^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsc70-2^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsc70-5^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsp110^K68S.UAS, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsp110^K68S.UAS, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsp110^KD.UAS, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsp110^KD.UAS, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by mrj^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by mrj^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsp110^HMS01080/DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has photoreceptor phenotype, non-suppressible by Hsp110^HMS01080/DnaJ-1^UAS.cKb, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsap\DNAJB4^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsap\HSPH1^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsap\HSPA4L^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsp60A^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsp68^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-1^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-2^UAS.cKa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^GMR.PU

(Kuo et al., 2013)

Diap1⁵/th[+], Scer\GAL4^GMR.PU, Zzzz\CAG^{127Q.UAS.Tag:HA} has ommatidium phenotype, non-suppressible by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has inclusion body | increased number phenotype, non-suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has ommatidium phenotype, non-suppressible by Hsap\STUB1^UAS.cAa, Scer\GAL4^GMR.PF

(Al-Ramahi et al., 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsap\STUB1^UAS.cAa, Scer\GAL4^GMR.PF

(Al-Ramahi et al., 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-suppressible by Hsap\STUB1^UAS.cAa, Scer\GAL4^GMR.PF

(Al-Ramahi et al., 2006)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has eye phenotype, non-suppressible by Hsap\ATXN1L^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Mizutani et al., 2005)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-suppressible by Diap1^UAS.cLa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-suppressible by Sirt1^EP2300/Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-suppressible by tara^EP3463/Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-suppressible by Scer\GAL4^GMR.PF/pum^EP3461

(Ghosh and Feany, 2004)

Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA} has retina phenotype, non-suppressible by BacA\p35^UAS.cUa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Other

Statement

Reference

Khc⁹, Scer\GAL4^179Y, Zzzz\CAG^{127Q.UAS.Tag:HA} has axon | larval stage phenotype

(Gunawardena et al., 2003)

Khc⁹, Scer\GAL4^Appl.G1a, Zzzz\CAG^{127Q.UAS.Tag:HA} has axon | larval stage phenotype

(Gunawardena et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Df(3R)Hsp70A and Df(3R)Hsp70B do not enhance the eye degeneration phenotype seen in flies expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Expression of DnaJ-1^Scer\UAS.cKb suppresses the eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU. Young animals have spotted pigment loss in the retina, indicating the degeneration of retinal cells, and this phenotype is more visible in aged animals. The photoreceptor loss is partially suppressed; ommatidia are observed that have small and missing rhabdomeres. The phenotype is still suppressed in a Df(3R)Hsp70A Df(3R)Hsp70B mutant background.

Expression of Hsp60^Scer\UAS.cKa does not suppress the external eye degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsp60^Scer\UAS.cKa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsp68^Scer\UAS.cKa does not suppress the external eye degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsp68^Scer\UAS.cKa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-1^Scer\UAS.cKa does not suppress the external eye degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-1^Scer\UAS.cKa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-2^Scer\UAS.cKa does not suppress the external eye degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-2^Scer\UAS.cKa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-3^Scer\UAS.cEa does not suppress the external eye degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-3^Scer\UAS.cEa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-4^Scer\UAS.cEa does not suppress the external eye degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-4^Scer\UAS.cEa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-5^Scer\UAS.cKa does not suppress the external eye degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70-5^Scer\UAS.cKa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsp83^Scer\UAS.cKa does not suppress the external eye degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsp83^Scer\UAS.cKa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70Cb^Scer\UAS.cKa does not suppress the external eye degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU. The retinal degeneration is also not suppressed.

Expression of Hsc70Cb^Scer\UAS.cKa suppresses the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU. No pigmentation loss is seen in either young or aged animals and at one day old all seven photoreceptors with normal sized rhabdomeres are detected.

In 10 day old animals, severe neuronal degeneration marked by vesicle accumulation, loss of rhabdomeres, and invasion of pigment granules is detected in flies expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70Cb^{K68S.Scer\UAS} does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70Cb^KD.Scer\UAS does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and DnaJ-1^Scer\UAS.cKb are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70Cb^Scer\UAS.cKa does not further suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and mrj^{Scer\UAS.T:Zzzz\FLAG} are co-expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsc70Cb^HMS01080 enhances the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU. Eyes have a complete loss of pigment.

Co-expression of Hsc70Cb^HMS01080 and DnaJ-1^Scer\UAS.cKb does not suppress the external eye degeneration phenotype seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU. Complete neuronal degeneration is observed in these flies.

Expression of Hsap\DNAJB1^Scer\UAS.cKa partially suppresses the loss of eye pigmentation seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsap\DNAJB4^Scer\UAS.cKa does not suppress the loss of eye pigmentation seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsap\HSPH1^Scer\UAS.cKa does not suppress the loss of eye pigmentation and external degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsap\HSPA4L^Scer\UAS.cKa does not suppress the loss of eye pigmentation and external degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Hsap\HSPA4L^Scer\UAS.cKa further suppresses the loss of eye pigmentation and external degeneration seen when Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} and Hsap\DNAJB1^Scer\UAS.cKa are expressed under the control of Scer\GAL4^GMR.PU.

(Kuo et al., 2013)

Co-expression of either Mdr49^HMS00400, Mdr50^HMS01448 or Mdr65^HMS01449 aggravates the eye degeneration phenotype seen in flies expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU, such that the proportion of flies showing a mild phenotype is decreased and the proportion showing a severe phenotype is increased. The number of inclusion bodies and disrupted rhabdomeres in the eye discs is increased and the disruption of the axonal projections of photoreceptor axons is more severe.

(Yadav and Tapadia, 2013)

XNP^C1/+ improves the hatching rate of embryos expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU and significantly reduces the fraction of deformed embryos.

The eye degeneration caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is enhanced by co-expression of XNP^EP635.

(Lee et al., 2012)

Co-expression of either DnaJ-1^Scer\UAS.cKa or Rpi^{dsRNA.Sym.Scer\UAS} suppresses the rough eye and loss of eye pigmentation phenotypes seen in adults expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

Co-expression of Rpi^Scer\UAS.cWa does not exacerbate the rough eye phenotype caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Wang et al., 2012)

Expression of Mmus\Prnp^{P101L.Scer\UAS.T:Hsap\PRNP-3F4} significantly enhances the pathogenic eye defects seen upon expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} in the eye (both lines under the control of Scer\GAL4^GMR.PF), with approximately 92% of ommatidia displaying aberrant structures.

(Park et al., 2011)

Co-expression of Hsp60D^{dsRNA.Sym.Scer\UAS} via Scer\GAL4^GMR.PU significantly suppresses the eye degeneration phenotype resulting from Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} overexpression.

Co-expression of two copies of Hsp60D^{dsRNA.Sym.Scer\UAS} with Scer\GAL4^GMR.PU-driven Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} partially restores phototaxis.

Co-expression of Hsp60D^{dsRNA.Sym.Scer\UAS} via Scer\GAL4^elav.PU partially suppresses the lethality resulting from Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} overexpression. The lethal phase is shifted from early to late pupa, although no flies emerge.

Co-expression of Pros26^1.Scer\UAS via Scer\GAL4^elav.PU does not significantly affect the Hsp60D^{dsRNA.Sym.Scer\UAS}-mediated partial suppression of the eye degeneration phenotype caused by Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} overexpression.

The enhancement of the eye degeneration resulting from the overexpression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^GMR.PU in a th⁵/+ background is not suppressed when Hsp60D^{dsRNA.Sym.Scer\UAS} is co-expressed.

The pharate stage lethality due to co-expression of th^{dsRNA.Scer\UAS} and Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^GMR.PU is not suppressed by simultaneous expression of Hsp60D^{dsRNA.Sym.Scer\UAS}.

The Hsp60D^{dsRNA.Sym.Scer\UAS}-mediated suppression of the eye phenotype resulting from the expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PU is less pronounced in the presence of Uba2^{C175S.Scer\UAS}.

The eye degeneration caused by Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} overexpression via Scer\GAL4^GMR.PU is enhanced by co-expression of Pros26^1.Scer\UAS.

Heterozygosity for th⁵ enhances the eye degeneration resulting from the overexpression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^GMR.PU.

Co-expression of th^{dsRNA.Scer\UAS} via Scer\GAL4^GMR.PU in Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}-expressing flies results in death at pharate stage.

Simultaneous expression of Uba2^{C175S.Scer\UAS} and Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^GMR.PU enhances the eye degeneration phenotype.

(Arya et al., 2010)

Df(3R)Hrb87F dominantly enhances the eye phenotype caused by Scer\GAL4^GMR.PF-mediated expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, leading to formation of extensive black lesions on the eye surface. Furthermore, 24% of these flies die as differentiated pupae.

Inclusion of one copy of P{Sym-UAS-Hsrω} improves the eye morphology and substantially reduces the mortality seen in flies expressing Scer\GAL4^GMR.PF-driven Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} in a Df(3R)Hrb87F/+ background.

Expression of Hsrω^EP3037 or Hsrω^EP93D in the Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Df(3R)Hrb87F/+ background significantly enhances the appearence of black lesions on the eye surface. Expression of Hsrω^EP3037 in this background also increases pupal mortality, whereas expression of Hsrω^EP93D has no effect on mortality.

Expression of nej^{F2161A.Scer\UAS.T:SV5\V5} in the Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} background results in 23% lethality at the pupal stage. Surviving flies show a reduction in eye size and a greater disruption in ommatidial arrays. Additional co-expression of one copy of P{Sym-UAS-Hsrω} improves the eye morphology and size and reduces pupal death, whereas co-expression of Hsrω^EP3037 or Hsrω^EP93D results in a greater reduction in eye size, near complete loss of ommatidial arrays and bristles and the appearence of black lesions on the eye surface. Co-expression of Hsrω^EP3037 also enhances pupal lethality, whereas co-expression of Hsrω^EP93D does not enhance pupal death.

Expression of nej^{dsRNA.Scer\UAS.cKa} in the Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} background results in >97% lethality at the pharate stage with eye degeneration being dramatically enhanced. Additional co-expression of P{Sym-UAS-Hsrω} robustly suppresses this enhanced eye damage, and also substantially reverses Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} eye degeneration in a dose-dependent manner. Co-expression of P{Sym-UAS-Hsrω} also improves emergence to adult stage in a dose-dependent manner.

The eye damage caused by Scer\GAL4^GMR.PF-mediated expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is suppressed by co-expression of one copy of P{Sym-UAS-Hsrω}, but enhanced by co-expression of Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS. Co-expression of P{Sym-UAS-Hsrω} still suppresses the damage in Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Pros26^1.B.Scer\UAS, Prosβ2^1.Scer\UAS eyes, but the eyes are not rescued to the degree seen in Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} eyes.

The increase in inclusion bodies in larval eye discs caused by Scer\GAL4^GMR.PF-mediated expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is reduced by co-expression of one copy of P{Sym-UAS-Hsrω}, but further increased by co-expression of Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS. However, co-expression of P{Sym-UAS-Hsrω} fails to reduce the number of inclusion bodies in the Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Pros26^1.B.Scer\UAS, Prosβ2^1.Scer\UAS background.

(Mallik and Lakhotia, 2010)

A Dp(3;3)st⁺g18 background (where Lmpt is duplicated) fails to suppress the degenerative eye phenotype found upon expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Nedelsky et al., 2010)

Co-expression of two copies of P{Sym-UAS-Hsrω} nearly completely suppresses the Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF eye phenotype in 54% of flies; photoreceptor neurons show improved morphology with the majority of ommatidia showing the normal seven rhabdomeres. Co-expression of one copy of P{Sym-UAS-Hsrω} also mitigates the damage caused by Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, but to lesser extent.

Co-expression of either Hsrω^EP3037 or Hsrω^EP93D significantly enhances the Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF eye phenotype, leading to extensive black lesions on the eye surface.

Co-expression of a single copy of P{Sym-UAS-Hsrω} eliminates the enhancing effect of Hsrω^EP3037 or Hsrω^EP93D expression on the Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF eye phenotype, and also substantially reverses the eye degeneration primarily induced by Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}.

Co-expression of one or two copies of P{Sym-UAS-Hsrω} restores normal phototactic behaviour to Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF flies.

Co-expression of a single copy of P{Sym-UAS-Hsrω} in the Scer\GAL4^elav-C155, Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} background increases the proportion of flies surviving to adulthood from 0% to 98%.

(Mallik and Lakhotia, 2009)

The neurodegeneration phenotype caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is enhanced by Hsrω⁰⁵²⁴¹/+.

(Akanksha et al., 2008)

The presence of hoip^GS7164 significantly enhances the neurodegeneration and rough eye phenotype seen upon expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

The presence of nop5^Scer\UAS.cMa significantly enhances the neurodegeneration and rough eye phenotype seen upon expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

The presence of Nop56^Scer\UAS.cMa significantly enhances the neurodegeneration and rough eye phenotype seen upon expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Murata et al., 2008)

Co-expression of Hsap\STUB1^Scer\UAS.cAa does not suppress the eye phenotypes caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Al-Ramahi et al., 2006)

The severity of the neurodegeneration phenotypes caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF are enhanced by Hsrω⁰⁵²⁴¹. In the adult eye, in a Hsrω⁰⁵²⁴¹/+ background, the eyes are significantly reduced in size and in some cases necrotic lesions are also seen. In the developing eye disc, in a Hsrω⁰⁵²⁴¹ homozygous background, a more severe disorganisation of the ommatidial units and their projections is seen; individual ommatidial cellular integrity is lost and axonal connections to the optic stalk appear highly irregular.

Eyes of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^GMR.PF ; Df(3R)Hrb87F/+ flies exhibit dark necrotic patches covering almost all of the entire eye. This phenotype is not seen in the Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}/Scer\GAL4^GMR.PF mutant, indicating that Df(3R)Hrb87F/+ acts as a dominant enhancer of poly-Q toxicity.

The neurodegeneration phenotype caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is enhanced by l(3)pl10^R/+; black necrotic patches cover almost the entire eye and eyes are reduced in size.

The neurodegeneration phenotype caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is enhanced by co-expression of either Hsrω^EP93D or Hsrω^EP3037 under the control of Scer\GAL4^GMR.PF; extensive black necrotic lesions are seen in the eye.

(Sengupta and Lakhotia, 2006)

The eye phenotype caused by expressing Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF, is not suppressed by coexpression of Hsap\Boat^{Scer\UAS.T:Zzzz\FLAG}.

(Mizutani et al., 2005)

When Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} is driven in neurons either by Scer\GAL4^Appl.G1a or Scer\GAL4^179Y, and combined with Khc⁹, mutant larval nerves contain axonal blockages. Mutant nerves also contain enlarged axons, some almost four or five times the diameter of those seen in wild-type. Sometimes "holes" lacking organelles are seen within the nerve.

(Gunawardena et al., 2003)

The addition of nej^EP1149 rescues the eye phenotype seen in Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF mutants. The addition of nej^EP1179 rescues the eye and the phototaxis phenotypes seen in Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF mutants. The addition of nej^P enhances the eye phenotype seen in Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF mutants.

(Taylor et al., 2003)

Expression of Mlf^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF suppresses the structural and pigmentation defects observed in Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} mutants.

The presence of Mlf^EU2490 dramatically reduces the external eye and pigmecntation defects caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Kazemi-Esfarjani and Benzer, 2002)

DnaJ-1^EU3500 suppresses of the eye degeneration phenotype caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF; the eye preserves its globular structure, pigmentation and uniform bristle arrangement and the structure of the retina is vastly improved. Tpr2^EU3220 suppresses of the eye degeneration phenotype caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF; external structure and pigmentation is improved. There is some improvement of internal retinal structure (some degeneration is seen). Co-expression of DnaJ-1^Scer\UAS.cKa or Tpr2^Scer\UAS.cKa suppresses of the eye degeneration phenotype caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Kazemi-Esfarjani and Benzer, 2000)

Complementation and Rescue Data

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Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1}

Zzzz\CAG^{127Q.UAS.Tag:HA}

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