FlyBase Allele Report: Dmel\G6pd[UAS.cLa]

General Information

Symbol

Dmel\G6pd^UAS.cLa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Legan

FlyBase ID

FBal0268136

Feature type

allele

Associated gene

Dmel\G6pd

Associated Insertion(s)

Carried in Construct

P{UAS-G6pd.L}

Also Known As

UAS-G6PD

Key Links

Transgenic product class

cDNA

(Legan et al., 2008)

wild_type

(Legan et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Legan et al., 2008)

wild_type

(Legan et al., 2008)

Mutagen

in vitro construct

(Legan et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-G6pd.L}

Cytology

Description

UASt regulatory sequences drive expression of a 2074bp Zw cDNA fragment.

(Legan et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

G6pd

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Besson et al., 2015)

ameliorates neurodegenerative disease

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Wang et al., 2012)

exacerbates myofibrillar myopathy 2

modeled by Hsap\CRYAB^R120G.UAS

(Xie et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response, with Scer\GAL4^Appl.G1a

(Legan et al., 2008)

abnormal oxidative stress response, with Scer\GAL4^arm.PS

(Legan et al., 2008)

abnormal oxidative stress response, with Scer\GAL4^elav-C155

(Besson et al., 2015)

female fertile, with Scer\GAL4^arm.PS

(Legan et al., 2008)

long lived, with Scer\GAL4^Appl.G1a

(Legan et al., 2008)

long lived, with Scer\GAL4^arm.PS

(Legan et al., 2008)

long lived, with Scer\GAL4^da.G32

(Legan et al., 2008)

long lived, with Scer\GAL4^Toll-6-D42

(Legan et al., 2008)

long lived, with Scer\GAL4^Tub.PU

(Legan et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

After 48 hours of exposure, flies expressing Zw^Scer\UAS.cLa under the control of Scer\GAL4^elav-C155 are more tolerant to hydrogen peroxide than wild-type flies.

(Besson et al., 2015)

Expression of Zw^Scer\UAS.cLa under the control of either Scer\GAL4^arm.PS, Scer\GAL4^tub.PU, Scer\GAL4^da.G32, Scer\GAL4^D42 or Scer\GAL4^Appl.G1a results in an increase in lifespan compared to controls.

Flies expressing Zw^Scer\UAS.cLa under the control of Scer\GAL4^arm.PS show increased resistance to hyperoxia (100% O[[2]]) compared to controls.

Expression of Zw^Scer\UAS.cLa under the control of either Scer\GAL4^arm.PS or Scer\GAL4^Appl.G1a show increased resistance to paraquat compared to controls.

(Legan et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

G6pd^UAS.cLa, Scer\GAL4^elav-C155 has abnormal oxidative stress response phenotype, non-suppressible by Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2015)

Enhancer of

Statement

Reference

G6pd^UAS.cLa, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\CRYAB^R120G.UAS, Scer\GAL4^GMR.PF

(Xie et al., 2013)

Suppressor of

Statement

Reference

G6pd^UAS.cLa, Scer\GAL4^hs.PB is a suppressor of increased mortality | adult stage | conditional phenotype of AMPKα^GD736, Scer\GAL4^hs.PB

(Lee et al., 2018)

G6pd^UAS.cLa, Scer\GAL4^hs.PB is a suppressor of abnormal immune response | adult stage phenotype of AMPKα^GD736, Scer\GAL4^hs.PB

(Lee et al., 2018)

G6pd^UAS.cLa/Scer\GAL4^hs.PB is a suppressor of increased mortality | adult stage | conditional phenotype of Scer\GAL4^hs.PB, wts^KK101055

(Lee et al., 2018)

G6pd^UAS.cLa/Scer\GAL4^hs.PB is a suppressor of abnormal immune response | adult stage phenotype of Scer\GAL4^hs.PB, wts^KK101055

(Lee et al., 2018)

Scer\GAL4^NP0001/G6pd^UAS.cLa is a suppressor of increased mortality | adult stage | conditional phenotype of Traf-like^Δ

(Lee et al., 2018)

Scer\GAL4^NP0001/G6pd^UAS.cLa is a suppressor of abnormal immune response | adult stage phenotype of Traf-like^Δ

(Lee et al., 2018)

G6pd^UAS.cLa, Scer\GAL4^hs.PB is a suppressor of increased mortality | adult stage | conditional phenotype of Atg1^GD7149, Scer\GAL4^hs.PB

(Lee et al., 2018)

G6pd^UAS.cLa, Scer\GAL4^hs.PB is a suppressor of abnormal immune response | adult stage phenotype of Atg1^GD7149, Scer\GAL4^hs.PB

(Lee et al., 2018)

G6pd^UAS.cLa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2015)

G6pd^UAS.cLa, Scer\GAL4^elav-C155 is a suppressor of abnormal neuroanatomy phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2015)

G6pd^UAS.cLa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Pdha1^GD12103, Scer\GAL4^elav-C155

(Besson et al., 2015)

G6pd^UAS.cLa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of ND-23^KK102085, Scer\GAL4^elav-C155

(Besson et al., 2015)

G6pd^UAS.cLa/Scer\GAL4^GMR.PF is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS

(Wang et al., 2012)

NOT Suppressor of

Statement

Reference

G6pd^UAS.cLa, Scer\GAL4^elav-C155 is a non-suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Hsap\SLC2A3^UAS.cBa, Scer\GAL4^elav-C155

(Besson et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

G6pd^UAS.cLa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\CRYAB^R120G.UAS, Scer\GAL4^GMR.PF

(Xie et al., 2013)

Suppressor of

Statement

Reference

Scer\GAL4^sns.PU/G6pd^UAS.cLa is a suppressor | partially of nephrocyte | larval stage phenotype of Scer\GAL4^sns.PU, dlg1^JF02287

(Xi et al., 2024)

Scer\GAL4^sns.PU/G6pd^UAS.cLa is a suppressor | partially of nephrocyte diaphragm | larval stage phenotype of Scer\GAL4^sns.PU, dlg1^JF02287

(Xi et al., 2024)

G6pd^UAS.cLa, Scer\GAL4^sns.PU is a suppressor | partially of nephrocyte | larval stage phenotype of Rab5^HMS00147, Scer\GAL4^sns.PU

(Xi et al., 2024)

G6pd^UAS.cLa, Scer\GAL4^sns.PU is a suppressor | partially of nephrocyte diaphragm | larval stage phenotype of Rab5^HMS00147, Scer\GAL4^sns.PU

(Xi et al., 2024)

G6pd^UAS.cLa, Scer\GAL4^sns.PU is a suppressor | partially of nephrocyte | larval stage phenotype of Amnionless^HMS02353, Scer\GAL4^sns.PU

(Xi et al., 2024)

G6pd^UAS.cLa, Scer\GAL4^sns.PU is a suppressor | partially of nephrocyte diaphragm | larval stage phenotype of Amnionless^HMS02353, Scer\GAL4^sns.PU

(Xi et al., 2024)

G6pd^UAS.cLa, Scer\GAL4^sns.PU is a suppressor | partially of nephrocyte | larval stage phenotype of Cubn^JF03118, Scer\GAL4^sns.PU

(Xi et al., 2024)

G6pd^UAS.cLa, Scer\GAL4^sns.PU is a suppressor | partially of nephrocyte diaphragm | larval stage phenotype of Cubn^JF03118, Scer\GAL4^sns.PU

(Xi et al., 2024)

G6pd^UAS.cLa, Scer\GAL4^elav-C155 is a suppressor of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Besson et al., 2015)

G6pd^UAS.cLa/Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^Q108.UAS

(Wang et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Zw^Scer\UAS.cLa significantly improves the survival of flies expressing Scer\GAL4^elav-C155>ND-23^KK102085.

Co-expression of Zw^Scer\UAS.cLa significantly improves the survival of flies expressing Scer\GAL4^elav-C155>l(1)G0334^GD12103.

(Besson et al., 2015)

Xenogenetic Interactions

Statement

Reference

Overexpression of Zw^Scer\UAS.cLa significantly extends lifespan and suppresses eye photoreceptor neurodegeneration in flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

Overexpression of Zw^Scer\UAS.cLa does not statistically change the survival of flies co-expressing Hsap\SLC2A3^Scer\UAS.cBa and Hsap\HTT^{Q93.ex1p.Scer\UAS} using Scer\GAL4^elav-C155.

12 day-old flies co-expressing Hsap\HTT^{Q93.ex1p.Scer\UAS} and Zw^Scer\UAS.cLa under the control of Scer\GAL4^elav-C155 display a significantly enhanced resistance to oxidative stress compared with wild-type.

(Besson et al., 2015)

Co-expression of two copies of Zw^Scer\UAS.cLa can partially rescue the rough eye phenotype caused by expression of Zzzz\CAG^{Q108.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Wang et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

G6pd^UAS.cLa

Zw^Scer\UAS.cLa

Zw^UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Legan

Secondary FlyBase IDs

References (11)

Report Sections

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