FB2024_03 , released June 25, 2024
Allele: Dmel\tkvDN.UAS.cUa
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General Information
Symbol
Dmel\tkvDN.UAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0120305
Feature type
allele
Associated gene
Dmel\tkv
Associated Insertion(s)
Carried in Construct
P{UAS-tkv.DN.U}
Also Known As
UAS-TkvDN, UAS-tkvDN
Key Links
Transgenic product class
dominant_negative_variant
(Martin-Blanco et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Martin-Blanco et al., 2000)
Mutagen
in vitro construct
(Martin-Blanco et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-tkv.DN.U}
Cytology
Description

UAS sequences drive expression of a dominant negative tkv.

(Martin-Blanco et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
tkv
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When tkvDN.Scer\UAS is driven by Scer\GAL4pnr-MD237, a strong thorax cleft phenotype is seen in the adult. Both hemi-nota remain extremely contracted and isolated. Naked cuticle joins the two heminota. When tkvDN.Scer\UAS is driven by Scer\GAL4LE a milder thorax cleft phenotype is seen in the adult. Cuticular polarity defects are seen at the midline. Occasionally stronger defects are seen.

      (Martin-Blanco et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Enhancer of
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Statement
      Reference

      tkvDN.UAS.cUa, Scer\GAL4ap.PU is an enhancer of wing disc phenotype of GliUAS.cSa, Scer\GAL4ap.PU

      (Sharifkhodaei et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of tkvDN.Scer\UAS enhances the migration of wing disc cells expressing GliScer\UAS.cSa under the control of Scer\GAL4ap.PU into the non-expressing side of the disc.

      (Sharifkhodaei et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tkvDN.Scer\UAS
      tkvDN.UAS.cUa
      tkvDN.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (10)