FB2024_03 , released June 25, 2024
Allele: Dmel\nompA1
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General Information
Symbol
Dmel\nompA1
Species
D. melanogaster
Name
FlyBase ID
FBal0121652
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: R621term.

    Nucleotide substitution: C1861T.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C11314534T

    Reported nucleotide change:

    C1861T

    Amino acid change:

    R621term | nompA-PA; R621term | nompA-PB; R621term | nompA-PC; R621term | nompA-PD

    Reported amino acid change:

    R621term

    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    In nompA1/nompA2 flies the sensory neurons associated with each bristle often fail to reach the bristle. The detached processes may be bent, curled or club shaped. Campaniform sensilla of wing vein L3 show a similar short fall in sensory neuron. In embryos the PNS appears normal. nompA1/nompA2 flies are uncoordinated with characteristic leg crossing and upheld wings. The phenotype is effectively lethal. nompA1/nompA2 flies show no change in TEP (transepithelial potential) in response to stimulation of thoracic bristle. Sound evoked potentials are absent from antennal chordotonal organs. The scolopidial array is disorganized and separated from its apical attachment site. The scolopales and sensory ciliary structures appear normal, but showed defects in the dendritic caps and their attachment to the cilia.

    Flies are uncoordinated showing frequent leg crossing and wings held up or out. Walking and righting ability is impaired. Spontaneous or induced (by light or mechanical stimuli) activity is vigorous. Mechanoreceptor potentials are invariably absent in thoracic macrochaete bristles. The sound evoked response (measured via the antennal nerve) is eliminated. ERGs are normal.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Rescued by
    Partially rescued by

    nompA1/nompA2 is partially rescued by nompAGFP

    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (3)