FB2024_03 , released June 25, 2024
Allele: Dmel\eyΔPD.UAS
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General Information
Symbol
Dmel\eyΔPD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0125068
Feature type
allele
Associated gene
Dmel\ey
Associated Insertion(s)
Carried in Construct
P{UAS-ey.ΔPD}
Also Known As
UAS-eyΔPD
Key Links
Transgenic product class
inframe_deletion
(Punzo et al., 2001)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Punzo et al., 2001)
Mutagen
in vitro construct
(Punzo et al., 2001)
Progenitor genotype
Carried in construct
P{UAS-ey.ΔPD}
Cytology
Description

UAS sequences drive expression of a mutated form of the E10 ey cDNA. This cDNA has had a NcoI/NgoMI fragment deleted removing the PD domain.

(Punzo et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
ey
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      eyScer\UAS.ΔPD; Scer\GAL4dpp.blk1 adults flies have ectopic eyes on various appendages. Expressivity of this phenotype varies depending on the P{UAS-ey.ΔPD} insertion used, correlating with the level of expression from the insertion.

      (Punzo et al., 2004)

      ey2 flies that also have eyScer\UAS.ΔPD, (driven by Scer\GAL4ey.PH) show a stronger eye phenotype than ey2 flies alone. About 64% of flies have a complete loss of the compound eye. Expression of eyScer\UAS.ΔPD when driven by Scer\GAL4dpp.blk1, in various imaginal discs, does not lead to the formation of any eye structures, but generates severely truncated appendages.

      (Punzo et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      eyΔPD.UAS, Scer\GAL4ey-OK107 is a suppressor of visible phenotype of AntpUAS.cBa, Scer\GAL4ey-OK107

      (Plaza et al., 2008)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      eyΔPD.UAS, Scer\GAL4ey-OK107 is a suppressor of eye phenotype of AntpUAS.cBa, Scer\GAL4ey-OK107

      (Plaza et al., 2008)

      eyΔPD.UAS is a suppressor of antenna | ectopic phenotype of BacA\p35UAS.cHa, Scer\GAL4ey.PH, ey2

      (Punzo et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of eyΔPD.Scer\UAS is able to rescue the eye loss caused by expression of AntpScer\UAS.cBa under the control of Scer\GAL4ey-OK107.

      (Plaza et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      eyΔPD.UAS/Scer\GAL4ey-OK107 fails to rescue eyOK107-16/eyJD

      (Clements et al., 2009)

      eyΔPD.UAS/Scer\GAL4ey-OK107 fails to rescue eyOK107-16/eyEH

      (Clements et al., 2009)

      eyΔPD.UAS/Scer\GAL4ey.PH fails to rescue ey2

      (Punzo et al., 2001)
      Comments

      Expression of eyΔPD.Scer\UAS under the control of Scer\GAL4ey-OK107 does not rescue the eye, mushroom body or central complex defects of eyEH/eyOK107-16 or eyJD/eyOK107-16 mutants.

      (Clements et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      eyScer\UAS.ΔPD
      eyΔPD.Scer\UAS
      eyΔPD.UAS
      eyΔPD
      (Plaza et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)