FB2024_03 , released June 25, 2024
Allele: Dmel\Syt1D2N.UAS.Tag:HA
Open Close
General Information
Symbol
Dmel\Syt1D2N.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0137075
Feature type
allele
Associated gene
Dmel\Syt1
Associated Insertion(s)
Carried in Construct
P{UAS-syt.D2N}
Key Links
Transgenic product class
missense_variant
(Robinson et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Robinson et al., 2002)
Mutagen
in vitro construct
(Robinson et al., 2002)
Progenitor genotype
Syt1UAS.Tag:HA
(Robinson et al., 2002)
Carried in construct
P{UAS-syt.D2N}
Cytology
Description

Amino acid replacement: D229N.

(Robinson et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Syt1
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Syt1D2N.UAS.Tag:HA/Scer\GAL4elav.PLu partially rescues Syt1D27/Syt1AD4

      (Robinson et al., 2002)

      Syt1D2N.UAS.Tag:HA/Scer\GAL4hs.PB partially rescues Syt1D27/Syt1AD4

      (Robinson et al., 2002)
      Comments

      Expression of sytD2N.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.PB or Scer\GAL4elav.PLu rescues the EJP amplitude in the neuromuscular junction of sytAD4/sytD27 larvae, although the EJP amplitude is on average smaller than wild type. The Ca2+ dependence of transmission in sytAD4/sytD27 larvae rescued by expression of sytScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.PB is not significantly different from the Ca2+ dependence of transmission in sytAD4/sytD27 larvae rescued by expression of sytD2N.Scer\UAS.T:Ivir\HA1.

      (Robinson et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Syt1D2N.Scer\UAS.T:Ivir\HA1
      Syt1D2N.UAS.Tag:HA
      sytD2N.Scer\UAS.T:Ivir\HA1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)