Insertion in the first exon of ics that disrupts the coding sequence.
icsBG02577/icsBG02577 flies are more resistant to ethanol-induced sedation than icsBG02577/+ or wild type flies, but have normal ethanol absorption and metabolism and show normal locomotion.
icsBG02577 homozygotes display wing blisters at 60% penetrance.
icsBG02577/icsBG02577 is a suppressor of partially lethal - majority die | recessive phenotype of msn03349
icsBG02577/icsBG02577 is a suppressor of embryonic/first instar larval cuticle | dorsal phenotype of bsk1
icsBG02577/icsBG02577 is a suppressor of adult thorax phenotype of msn03349
icsBG02577/icsBG02577 is a suppressor of embryonic/first instar larval cuticle | dorsal phenotype of msn102
icsBG02577 has no effect on the viability of flies expressing stckwt.T:Zzzz\FLAG in a stck3R-17/stck18 mutant background.
The addition of icsBG02577 reduces the viability of flies expressing stckQ38A.T:Zzzz\FLAG in a stck3R-17/stck18 mutant background. Between 6 and 34% of the expected number of progeny are seen, with the majority of the lethality taking place during the larval and pharate stages. The rescued larvae display a range of sizes, including presumptive first instar larvae that appear stumpy, exhibit sluggish movement and do not progress in development.
Homozygosity for icsBG02577 suppresses the msn102 'dorsal open' phenotype, reducing its incidence from approximately 30% to approximately 2%.
Homozygosity for icsBG02577 increases the incidence of eclosion seen in msn03349 homozygotes from approximately 0.5% to approximately 3%, and completely suppresses the msn03349 thorax closure defects.
Homozygosity for icsBG02577 suppresses the bsk1 'dorsal open' phenotype, reducing its incidence from approximately 60% to approximately 30%.