FlyBase Allele Report: Dmel\ics[BG02577]

General Information

Symbol

Dmel\ics^BG02577

Species

D. melanogaster

Name

FlyBase ID

FBal0137650

Feature type

allele

Associated gene

Dmel\ics

Associated Insertion(s)

P{GT1}ics^BG02577

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Kadrmas et al., 2004)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{GT1}ics^BG02577

Cytology

Description

Insertion in the first exon of ics that disrupts the coding sequence.

(Kadrmas et al., 2004)

Allele components

Component

Use(s)

Inserted element

P{GT1}

gene trap

polyA trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:13,641,119..13,641,119 [-]

(Elias et al., 2012, Kadrmas et al., 2004, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant | adult stage | recessive

(Ojelade et al., 2015)

fertile

(Kadrmas et al., 2004)

viable

(Elias et al., 2012, Kadrmas et al., 2004)

visible | adult stage | recessive

(Kadrmas et al., 2004)

Phenotype Manifest In

wing blade

(Kadrmas et al., 2004)

Detailed Description

Statement

Reference

ics^BG02577/ics^BG02577 flies are more resistant to ethanol-induced sedation than ics^BG02577/+ or wild type flies, but have normal ethanol absorption and metabolism and show normal locomotion.

(Ojelade et al., 2015)

ics^BG02577 homozygotes display wing blisters at 60% penetrance.

(Kadrmas et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ics^BG02577/ics^BG02577 is a suppressor of partially lethal - majority die | recessive phenotype of msn⁰³³⁴⁹

(Kadrmas et al., 2004)

Other

Statement

Reference

ics^BG02577, stck¹⁸/stck^3R-17, stck^{Q38A.Tag:FLAG} has partially lethal - majority die phenotype

(Elias et al., 2012)

ics^BG02577, stck¹⁸/stck^3R-17, stck^{Q38A.Tag:FLAG} has abnormal developmental rate | first instar larval stage phenotype

(Elias et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

ics^BG02577/ics^BG02577 is a suppressor of embryonic/first instar larval cuticle | dorsal phenotype of bsk¹

(Kadrmas et al., 2004)

ics^BG02577/ics^BG02577 is a suppressor of adult thorax phenotype of msn⁰³³⁴⁹

(Kadrmas et al., 2004)

ics^BG02577/ics^BG02577 is a suppressor of embryonic/first instar larval cuticle | dorsal phenotype of msn¹⁰²

(Kadrmas et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

ics^BG02577 has no effect on the viability of flies expressing stck^{wt.T:Zzzz\FLAG} in a stck^3R-17/stck¹⁸ mutant background.

The addition of ics^BG02577 reduces the viability of flies expressing stck^{Q38A.T:Zzzz\FLAG} in a stck^3R-17/stck¹⁸ mutant background. Between 6 and 34% of the expected number of progeny are seen, with the majority of the lethality taking place during the larval and pharate stages. The rescued larvae display a range of sizes, including presumptive first instar larvae that appear stumpy, exhibit sluggish movement and do not progress in development.

(Elias et al., 2012)

Homozygosity for ics^BG02577 suppresses the msn¹⁰² 'dorsal open' phenotype, reducing its incidence from approximately 30% to approximately 2%.

Homozygosity for ics^BG02577 increases the incidence of eclosion seen in msn⁰³³⁴⁹ homozygotes from approximately 0.5% to approximately 3%, and completely suppresses the msn⁰³³⁴⁹ thorax closure defects.

Homozygosity for ics^BG02577 suppresses the bsk¹ 'dorsal open' phenotype, reducing its incidence from approximately 60% to approximately 30%.

(Kadrmas et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12706

w¹¹¹⁸; P{GT1}ics^BG02577

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

BG:BACR48E02.4^BG02577

CG9031^BG02577

Rsu-1^BG02577

ics

(Kadrmas et al., 2004)

ics^BG02577

(Elias et al., 2012)

ics^BG

(Ojelade et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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