Individuals expressing PGRP-LE^UAS.Tag:FLAG under the control of Scer\GAL4^He.PZ present a significantly decreased bacterial load upon infection with the non-pathogenic E. coli, as compared to equally infected controls.

Isolated circulating naive macrophages from larvae expressing PGRP-LE^UAS.Tag:FLAG under the control of Scer\GAL4^He.PZ show increased internalization of E.coli bacteria upon infection, as compared to equally infected controls.

Expression of PGRP-LE^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^da.G32 increases the survival rate of flies which are susceptible to L. monocytogenes.

Scer\GAL4^NP2610-3-1-mediated expression of PGRP-LE^{Scer\UAS.T:Zzzz\FLAG} does not induce significant changes in the epithelial structure of the larval trachea.

Expression of PGRP-LE^{Scer\UAS.T:Zzzz\FLAG} driven by Scer\GAL4^S106-GS dramatically increases the survival of both females and males following infection with Pseudomonas aeruginosa in both young and old animals. Enhanced resistance to other pathogenic strains of bacteria, including Enterococcus faecalis and Staphylococcus aureus is statistically significant but lesser in magnitude.

Acute overexpression of PGRP-LE^{Scer\UAS.T:Zzzz\FLAG} driven by Scer\GAL4^S106-GS does not adversely affect normal behaviours, as evidenced by normal patterns of negative geotaxis, heat tolerance, or reproductive output for up to one week following induction of transgene expression. In contrast, chronic activation of PGRP-LE^{Scer\UAS.T:Zzzz\FLAG} driven by Scer\GAL4^S106-GS throughout the adult stage of flies results in significantly shorter lifespan in both males and females compared to controls.

When a weak expressing PGRP-LE^{Scer\UAS.T:Zzzz\FLAG} insertion line is driven by Scer\GAL4^hs.PB in the absence of heat shock, the flies exhibit a cuticle defect at the midline of the dorsal abdomen. A strong expressing leads to lethality. When PGRP-LE^{Scer\UAS.T:Zzzz\FLAG} is driven by Scer\GAL4^c564 melanisation can been seen in larval cuticle.

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo has increased cell number | P-stage phenotype, suppressible by Pvf2^HMJ23540, Scer\GAL4^repo

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo has increased cell number | P-stage phenotype, suppressible by Rel^HM05154, Scer\GAL4^repo

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106 has abnormal immune response phenotype, suppressible by Tak1^K46R.M.UAS, Scer\GAL4^Switch1.106

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106 has abnormal immune response phenotype, suppressible by Fadd^RNAi.UAS, Scer\GAL4^Switch1.106

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106 has abnormal immune response phenotype, suppressible by Rel^E20, Scer\GAL4^Switch1.106

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo has increased cell number | P-stage phenotype, non-suppressible by bsk^HMC03539, Scer\GAL4^repo

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^Switch1.106 has abnormal immune response phenotype, non-suppressible by Rel^E23, Scer\GAL4^Switch1.106

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo has embryonic/larval plasmatocyte | increased number | P-stage phenotype, suppressible by Pvf2^HMJ23540, Scer\GAL4^repo

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo has pupal central nervous system phenotype, suppressible by Pvf2^HMJ23540, Scer\GAL4^repo

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo has embryonic/larval plasmatocyte | increased number | P-stage phenotype, suppressible by Rel^HM05154, Scer\GAL4^repo

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo has pupal central nervous system phenotype, suppressible by Rel^HM05154, Scer\GAL4^repo

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo has embryonic/larval plasmatocyte | increased number | P-stage phenotype, non-suppressible by bsk^HMC03539, Scer\GAL4^repo

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^repo has pupal central nervous system phenotype, non-suppressible by bsk^HMC03539, Scer\GAL4^repo

PGRP-LE^UAS.Tag:FLAG, Scer\GAL4^c564 has melanotic mass phenotype, non-suppressible by spz⁴